FB2025_01 , released February 20, 2025
Allele: Dmel\fz2UAS.Tag:HA.GFP
Open Close
General Information
Symbol
Dmel\fz2UAS.Tag:HA.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0179725
Feature type
allele
Associated gene
Dmel\fz2
Associated Insertion(s)
Carried in Construct
P{UAS-3xHA-fz2-GFP}
Also Known As
UAS-fz2
Key Links
Transgenic product class
wild_type
(Chen et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Chen et al., 2004)
Mutagen
in vitro construct
(Chen et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-3xHA-fz2-GFP}
Cytology
Description

UAS sequences drive expression of wild-type fz2 in which the signal peptide has been replaced by Tag:SS(wg) plus 3 copies of the epitope tag Tag:HA. In addition, the coding sequence is tagged just upstream of the last amino acid with GFP.

(Chen et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
fz2
Tagged with
GFP
Tag:HA
Tag:SS(wg)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      DOES NOT ameliorate  Alzheimer's disease
      modeled by Hsap\APPAβ42.UAS.Tag:SS(rPENK)
      (Lüchtenborg and Katanaev, 2014)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      fz2Scer\UAS.T:Avic\GFP expression, under the control of Scer\GAL4Bx-MS1096 induces ectopic margin bristles that show no asymmetric division defects.

      (Katanaev and Tomlinson, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Coexpression of fz2Scer\UAS.T:Avic\GFP and G-oα47AScer\UAS.cKa under the control of Scer\GAL4Bx-MS1096 results in mutual enhancement of their respective phenotypes.

      (Katanaev and Tomlinson, 2006)
      Xenogenetic Interactions
      Statement
      Reference

      Expression of fz2Scer\UAS.T:Avic\GFP does not suppress the reduction in lifespan seen when Hsap\APPAβ42.Scer\UAS is expressed in motoneurons under the control of Scer\GAL4D42.

      Expression of fz2Scer\UAS.T:Avic\GFP does not suppress the reduction in lifespan seen when Hsap\APPAβ42.Scer\UAS is expressed pan-neuronally under the control of Scer\GAL4elav.PU.

      (Lüchtenborg and Katanaev, 2014)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      fz2Scer\UAS.T:Avic\GFP
      fz2UAS.GFP
      fz2UAS.Tag:HA.GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (4)