FB2025_01 , released February 20, 2025
Allele: Dmel\eygPxA1
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General Information
Symbol
Dmel\eygPxA1
Species
D. melanogaster
Name
FlyBase ID
FBal0179917
Feature type
allele
Associated gene
Dmel\eyg
Associated Insertion(s)
P{lacW}PxA1a
P{lacW}PxA1b
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Dominguez et al., 2004)
Mutagen
P-element activity
(Dominguez et al., 2004)
Progenitor genotype
eygM3-12
(Dominguez et al., 2004)
Associated Insertion(s)
P{lacW}PxA1a
P{lacW}PxA1b
Cytology
Description

Consists of a deletion that starts 23bp upstream of eyg and extends 11.8kb downstream of the gene. Contains two P{lacW} element insertions at bases -124 and -147 relative to the translation start of eyg and in the same orientation as the gene.

(Dominguez et al., 2004)
Allele components
Component
Use(s)
Inserted element
P{lacW}
P{lacW}
Encoded product / tool
lacZ
lacZ
Tagged with
Tag:NLS(P)
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      eygPxA1 mutants suffer head loss, making this mutation lethal. There is also a severe groove on the thorax.

      (Dominguez et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Flies overexpressing DlScer\UAS.cDa under the control of Scer\GAL4ey.PH that are also eygPxA1/eygXE119 mutants have eyes that are reduced in size or completely lack eyes altogether.

      (Dominguez et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      eyg123M11/eygPxA1 is partially rescued by Scer\GAL4ey.PH/eygUAS.lune

      (Dominguez et al., 2004)
      Comments

      One copy of eygScer\UAS.lune under the control of Scer\GAL4ey.PH rescues eygPxA1/eyg123M11 mutants to healthy adulthood with almost normal-sized eyes.

      (Dominguez et al., 2004)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      eygPxA1
      (Luque and Milan, 2007)
      eygXA1
      (Gutierrez-Aviño et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)