Comments on Models/Modifiers Based on Experimental Evidence
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The G594S mutation is equivalent to the G426S mutation associated with branchiootorenal syndrome and ocular defects in humans. Eye defects are seen in flies when eyaG594S.Scer\UAS.T:Zzzz\FLAG is expressed in a eya2 mutant background.
Expression of eyaG594S.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4dpp.blk1 significantly rescues eye tissue formation in eya2 flies. The recovered eye tissue is located more dorsally than normal and is almost always split into multiple independent eye fields.