FlyBase Allele Report: Dmel\cv[UAS.cVa]

General Information

Symbol

Dmel\cv^UAS.cVa

Species

D. melanogaster

Name

FlyBase ID

FBal0180270

Feature type

allele

Associated gene

Dmel\cv

Associated Insertion(s)

Carried in Construct

P{UAS-cv}

Key Links

Transgenic product class

cDNA

(Vilmos et al., 2005)

wild_type

(Vilmos et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Vilmos et al., 2005)

wild_type

(Vilmos et al., 2005)

Mutagen

in vitro construct

(Vilmos, 2005, Vilmos et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-cv}

Cytology

Description

UAS sequences drive expression of a cv cDNA.

(Vilmos et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with cv⁴³

(Jaramillo et al., 2009)

Phenotype Manifest In

posterior crossvein, with cv⁴³

(Jaramillo et al., 2009)

wing vein, with Scer\GAL4^A9

(Vilmos et al., 2005)

Detailed Description

Statement

Reference

Expression of cv^Scer\UAS.cVa under the control of Scer\GAL4^A9 can induce small fragments of extra veins and a delta phenotype, consistent with mild pro-BMP activity. When cv^Scer\UAS.cVa and cv-2^Scer\UAS.cVa are co-expressed under the regulation of Scer\GAL4^A9, there is no evidence of strong BMP inhibition.

(Vilmos et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Scer\GAL4^A9, cv^UAS.cVa, sog^UAS.cYa has wing phenotype, non-suppressible by dpp^UAS.cHa/Scer\GAL4^A9

(Vilmos et al., 2005)

NOT Suppressor of

Statement

Reference

Scer\GAL4^A9/cv^UAS.cVa is a non-suppressor of wing phenotype of Scer\GAL4^A9, gbb^UAS.cKa

(Vilmos et al., 2005)

Scer\GAL4^A9, sog^UAS.cYa, cv^UAS.cVa is a non-suppressor of wing phenotype of Scer\GAL4^A9, dpp^UAS.cHa

(Vilmos et al., 2005)

Scer\GAL4^A9/cv^UAS.cVa is a non-suppressor of wing phenotype of Scer\GAL4^A9, dpp^UAS.cHa

(Vilmos et al., 2005)

Other

Statement

Reference

Scer\GAL4^A9, cv^UAS.cVa, gbb^UAS.cKa, sog^UAS.cYa has crossvein phenotype

(Vilmos et al., 2005)

Scer\GAL4^en-e16E, cv^UAS.cVa, sog^UAS.cYa has wing | posterior phenotype

(Vilmos et al., 2005)

Scer\GAL4^A9, cv^UAS.cVa, sog^UAS.cYa has wing phenotype

(Vilmos et al., 2005)

Scer\GAL4^A9, cv^UAS.cVa, sog^UAS.cYa has wing cell phenotype

(Vilmos et al., 2005)

Scer\GAL4^ptc-559.1, cv^UAS.cVa, sog^UAS.cYa has wing phenotype

(Vilmos et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of cv^Scer\UAS.cVa and sog^Scer\UAS.cYa under the regulation of Scer\GAL4^A9 produces a phenotype resembling early loss of BMP signalling in the organiser that runs along the anterior-posterior boundary (i.e. reduction in size and loss of intervein regions). Co-expression of cv^Scer\UAS.cVa and sog^Scer\UAS.cYa along the anterior-posterior boundary under the regulation of Scer\GAL4^ptc-559.1, affects structures throughout the wing, whereas co-expression in the posterior compartment under the regulation of Scer\GAL4^en-e16E affects only posterior structures. When cv^Scer\UAS.cVa and sog^Scer\UAS.cYa are co-expressed under the regulation of Scer\GAL4^A9, there is strong BMP inhibition. Co-expression of cv^Scer\UAS.cVa with dpp^Scer\UAS.cHa, under the regulation of Scer\GAL4^A9 has no detectable effect on the overexpression phenotype of dpp^Scer\UAS.cHa (wing disruption). Co-expression of cv^Scer\UAS.cVa and sog^Scer\UAS.cYa, with dpp^Scer\UAS.cHa, under the regulation of Scer\GAL4^A9 has no detectable effect on the overexpression phenotype of dpp^Scer\UAS.cHa (wing disruption). Co-expression of cv^Scer\UAS.cVa with gbb^Scer\UAS.cKa, under the regulation of Scer\GAL4^A9 has no detectable effect on the overexpression phenotype of gbb^Scer\UAS.cKa (wing disruption). Co-expression of cv^Scer\UAS.cVa and sog^Scer\UAS.cYa, with gbb^Scer\UAS.cKa, under the regulation of Scer\GAL4^A9 re-establishes the intervein tissue and the longitudinal veins with a series of expanded crossveins between L2 and L3 on the wing. Therefore, cv and sog interact together to suppress the wing phenotype of gbb.

(Vilmos et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^ptc-559.1/cv^UAS.cVa rescues cv¹

(Vilmos et al., 2005)

Scer\GAL4^ptc-559.1/cv^UAS.cVa rescues cv¹⁸

(Vilmos et al., 2005)

Partially rescues

Scer\GAL4^how-24B/cv^UAS.cVa partially rescues cv⁴³

(Jaramillo et al., 2009)

Scer\GAL4^ptc-559.1/cv^UAS.cVa partially rescues cv⁴³

(Jaramillo et al., 2009)

cv^UAS.cVa partially rescues cv⁴³

(Jaramillo et al., 2009)

Comments

Two copies of cv^Scer\UAS.cVa (in the absence of a Scer\GAL4 driver) show some rescue of the crossvein phenotype of cv⁴³ mutants, while the tergal depressor of trochanter (TDT) muscle phenotype and jump ability is completely rescued. One copy of cv^Scer\UAS.cVa (in the absence of a Scer\GAL4 driver) does not rescue either the crossvein of TDT phenotypes of cv⁴³ mutants.

Expression of cv^Scer\UAS.cVa under the control of either Scer\GAL4^how-24B or Scer\GAL4^ptc-559.1 significantly rescues both the crossvein and TDT defects of cv⁴³ mutants.

(Jaramillo et al., 2009)

cv¹⁸ hemizygotes can be rescued by the expression of cv^Scer\UAS.cVa under the control of Scer\GAL4^ptc-559.1 along the anterior-posterior border, rescues both the anterior crossvein and the posterior crossvein in cv mutants. cv¹ hemizygotes can be rescued by the expression of cv^Scer\UAS.cVa under the control of Scer\GAL4^ptc-559.1 along the anterior-posterior border, rescues both the anterior crossvein and the posterior crossvein in cv mutants.

(Vilmos et al., 2005)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

cv^Scer\UAS.cVa

cv^UAS.cVa

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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