FB2025_01 , released February 20, 2025
Allele: Dmel\bazRNAi.Sym.UAS
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General Information
Symbol
Dmel\bazRNAi.Sym.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0180866
Feature type
allele
Associated gene
Dmel\baz
Associated Insertion(s)
Carried in Construct
P{UAS-baz.RNAi.Sym}
Key Links
Transgenic product class
RNAi_reagent
(Pinheiro and Montell, 2004)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Pinheiro and Montell, 2004)
Mutagen
in vitro construct
(Pinheiro and Montell, 2004)
Progenitor genotype
Carried in construct
P{UAS-baz.RNAi.Sym}
Cytology
Description

Sense-antisense transcription (driven by two convergent arrays of UAS regulatory sequences) of a 2kb fragment of baz (nucleotides 28506 to 30554 of genomic clone - GenBank:AE003504) results in double stranded RNA (dsRNA) expression.

(Pinheiro and Montell, 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
baz
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Border cell migration is incomplete in 14% of stage 10 egg chambers from (bazScer\UAS.Sym bazScer\UAS.a.Sym)X2; Scer\GAL4slbo.2.6 flies. This increases to 33% in flies also heterozygous for baz4 and is also increased by the presence of Scer\GAL4upd in addition to Scer\GAL4slbo.2.6. The organisation of border cell clusters is abnormal in these flies.

      (Pinheiro and Montell, 2004)

      Border cell migration is incomplete in 14% of stage 10 egg chambers from (bazdsRNA.Sym.Scer\UAS)X2; Scer\GAL4slbo.2.6 flies. This increases to 33% in flies also heterozygous for baz4 and is also increased by the presence of Scer\GAL4upd in addition to Scer\GAL4slbo.2.6. The organisation of border cell clusters is abnormal in these flies.

      (Pinheiro and Montell, 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      P{Sym-baz} contains baz sequences flanked on both sides by Scer\UAS regulatory sequences in opposite orientation (producing alleles bazScer\UAS.Sym and bazScer\UAS.a.Sym). Expression from both of these Scer\UAS sequences should result in both sense and antisense copies of the baz sequences, producing dsRNA which can cause RNAi (dsRNA interference).

      (Pinheiro and Montell, 2004)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      bazRNAi.Sym.UAS
      bazScer\UAS.Sym
      bazdsRNA.Sym.Scer\UAS
      bazdsRNA.Sym.UAS
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0180865
      References (3)