Allele Dmel\ab^Scer\UAS.cBa

General Information
Symbol	Dmel\ab^Scer\UAS.cBa	Species	D. melanogaster
Name	UAS construct of Biehs	FlyBase ID	FBal0181023
Feature type	allele	Associated gene	Dmel\ab

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Cook et al., 2004)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Expression of ab cDNA is under the control of Scer\UAS sequences. (Cook et al., 2004)
Carried in construct	P{UAS-ab.B} (Cook, 2006.6.12, Cook et al., 2004, Li et al., 2004, König et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective, with Scer\GAL4^109(2)80 (Li et al., 2004)
Phenotype Manifest In
	abdominal posterior ventral multidendritic neuron vdap, with Scer\GAL4²²¹ (Li et al., 2004) dorsal multidendritic neuron, with Scer\GAL4^109(2)80 (Li et al., 2004) dorsal multidendritic neuron ddaC, with Scer\GAL4⁴⁷⁷ (Li et al., 2004) dorsal multidendritic neuron ddaE, with Scer\GAL4²²¹ (Li et al., 2004) female germline cell \| somatic clone \| supernumerary, with Scer\GAL4^Act.PU (König et al., 2011) germline cell \| supernumerary \| heat sensitive, with Scer\GAL4^ptc-559.1, Scer\GAL80^ts.αTub84B (König et al., 2011) wing vein \| cell non-autonomous \| ectopic \| somatic clone, with Scer\GAL4^Ubx.PdC (Cook et al., 2004)
Detailed Description
	Statement Reference Expression of ab[Scer\UAS.cBa] under the control of Scer\GAL4[ptc-559.1] in the somatic cells of the germarium (using the temperature sensitive Scer\GAL80[ts.αTub84B] allele to restrict expression to the adult stage) results in supernumerary germline cells containing a single spectrosome. Single cell somatic clones in the ovary expressing ab[Scer\UAS.cBa] under the control of Scer\GAL4[Act.PU] and induced during niche development resemble niche cells by their shape and their ability to anchor germline cells containing a single spectrosome (SSCs). The mutant germaria contain supernumerary SSCs compared to controls. (König et al., 2011) Ectopic veins form in a cell-autonomous fashion within small ab^Scer\UAS.cBa; Scer\GAL4^Ubx.PdC somatic clones in the wing. (Cook et al., 2004) Ectopic expression of ab^Scer\UAS.cBa under the control of Scer\GAL4^109(2)80 results in a 40% reduction in the number of dendritic ends of all dorsal cluster DA neurons in second instar larvae. Expression of ab^Scer\UAS.cBa in ddaC neurons, driven by Scer\GAL4⁴⁷⁷, leads to a 51% decrease in the dendritic branching of these neurons. Expression of ab^Scer\UAS.cBa in ddaE and vpda neurons, driven by Scer\GAL4²²¹, leads to a decrease in dendritic branching in these neurons. (Li et al., 2004)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement Reference ab^Scer\UAS.cBa/Scer\GAL4²²¹ is a suppressor \| partially of abdominal posterior ventral multidendritic neuron vdap phenotype of Scer\GAL4²²¹, ct^Scer\UAS.cPa (Li et al., 2004)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	ab^Scer\UAS.cBa/Scer\GAL4²²¹ rescues ab¹/ab²⁶ (Li et al., 2004) ab^Scer\UAS.cBa/Scer\GAL4²²¹ rescues ab²⁶/[+] (Li et al., 2004)
Comments
Stocks ( 1 )
Bloomington	23639 w^*; P{UAS-ab.B}55
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	ab^Scer\UAS.cBa
Name Synonym	UAS construct of Biehs (Cook et al., 2004)
Secondary FlyBase IDs

References ( 4 )
Research paper	König et al., 2011, EMBO J. 30(8): 1549--1562 Ecdysteroids affect Drosophila ovarian stem cell niche formation and early germline differentiation. [FBrf0213531] Cook et al., 2004, Development 131(9): 2113--2124 brinker and optomotor-blind act coordinately to initiate development of the L5 wing vein primordium in Drosophila. [FBrf0174576] Li et al., 2004, Neuron 43(6): 823--834 BTB/POZ-zinc finger protein abrupt suppresses dendritic branching in a neuronal subtype-specific and dosage-dependent manner. [FBrf0180577]
Personal communication to FlyBase	Cook, 2006.6.12, P{UAS-ab.B}55. P{UAS-ab.B}55. [FBrf0200082]

Allele Dmel\abScer\UAS.cBa

Allele Dmel\ab^Scer\UAS.cBa