Allele Dmel\Smn^B

General Information
Symbol	Dmel\Smn^B	Species	D. melanogaster
Name		FlyBase ID	FBal0181513
Feature type	allele	Associated gene	Dmel\Smn

Map ( GBrowse )
Allele class	amorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	amorphic allele - genetic evidence (Rajendra et al., 2007)
Mutagen	ethyl methanesulfonate (Chan et al., 2003)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3L:16,573,681..16,573,681 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=C16573681T pr_change=S201F\|Smn-PA reported_pr_change=S201F (Chan et al., 2003)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: 201F. (Chan et al., 2003)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| larval stage \| recessive (Chan et al., 2003, Shpargel et al., 2009) locomotor behavior defective \| larval stage (Shpargel et al., 2009)
Phenotype Manifest In

Detailed Description
	Statement Reference Approximately one-third of homozygous larvae survive beyond day 8 after egg laying, a period when the control larvae have already pupated. Some of these animals form pseudopupae before dying. Homozygous second-third instar larvae show impaired motor function, showing a smaller distance travelled in the 20 seconds after movement was stimulated with a needle than control larvae. (Shpargel et al., 2009) Homozygotes die as late larvae. (Chan et al., 2003)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	Smn^73Ao (Chan et al., 2003)
Rescued by	Smn^B is rescued by Smn^{Scer\UAS.T:Avic\GFP-YFP.Venus}/Scer\GAL4^da.G32 (Rajendra et al., 2007)
Comments	The lethality of Smn[B] is rescued by expression of Smn[Scer\UAS.T:Avic\GFP-YFP.Venus] under the control of Scer\GAL4[da.G32]. (Rajendra et al., 2007)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	smn^B (Chan et al., 2003) Smn^B (Shpargel et al., 2009, Rajendra et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Shpargel et al., 2009, Mol. Biol. Cell 20(1): 90--101 Gemin3 is an essential gene required for larval motor function and pupation in Drosophila. [FBrf0206864] Rajendra et al., 2007, J. Cell Biol. 176(6): 831--841 A Drosophila melanogaster model of spinal muscular atrophy reveals a function for SMN in striated muscle. [FBrf0194681] Chan et al., 2003, Hum. Mol. Genet. 12(12): 1367--1376 Neuromuscular defects in a Drosophila survival motor neuron gene mutant. [FBrf0160443]

Allele Dmel\SmnB

Allele Dmel\Smn^B