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General Information
Symbol
Dmel\Sirt25B-2-35
Species
D. melanogaster
Name
FlyBase ID
FBal0181533
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Deletion of the Sirt2 coding region.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Sirt25B-2-35 males exhibit a reduction in sperm motility and defects in pupal spermatid axoneme.

Sirt25B-2-35 adults exhibit a reduction in their climbing ability.

Sirt25B-2-35 wing disc centrioles are shorter and spermatocyte centrioles display extensions positive for Ana1.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
NOT Enhanced by
Suppressed by
Statement
Reference
NOT suppressed by
NOT Enhancer of
Suppressor of
Statement
Reference
NOT Suppressor of
Other
Phenotype Manifest In
NOT Enhanced by
Statement
Reference
NOT suppressed by
Statement
Reference

Sirt25B-2-35 has centriole phenotype, non-suppressible by HDAC6KO

Sirt25B-2-35 has spermatozoon phenotype, non-suppressible by Cep97Δ

NOT Enhancer of
Statement
Reference
Suppressor of
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

The rhabdomere loss observed upon expression of Hsap\HTTQ93.ex1p.Scer\UAS under the control of Scer\GAL4elav.PU is partially rescued by Sirt25B-2-35 homozygosity or Heterozygosity.

A reduction in the level of Sirt2, through a Sirt25B-2-35 heterozygous background, leads to greater survival of photoreceptor neurons in flies expressing Hsap\HTTQ93.ex1p.Scer\UAS under the control of Scer\GAL4elav-C155, although this background does not suppress lethality.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)