FlyBase Allele Report: Scer\GAL4[A58]

General Information

Symbol

Scer\GAL4^A58

Species

S. cerevisiae

Name

FlyBase ID

FBal0181674

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

P{GAL4}A58

Carried in Construct

Also Known As

a58-GAL4, Gal4^A58

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Galko and Krasnow, 2004)

Progenitor genotype

Associated Insertion(s)

P{GAL4}A58

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{GAL4}

enhancer trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

embryonic/larval epidermis

(Brock et al., 2012, Sinenko et al., 2011, Tennessen et al., 2011)

first instar larval stage -- third instar larval stage

embryonic/larval epidermis

(Galko and Krasnow, 2004)

Additional Information

Statement

Reference

Drives pan-epidermal expression at larval stages.

(FlyBase Curators, 2017)

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body size | P-stage, with EcR^GD1428

(Heredia et al., 2021)

abnormal body size | P-stage, with Ilp8^HMS06016, Scer\GAL4^MsrA.657

(Heredia et al., 2021)

abnormal cell shape | larval stage | conditional, with Cdc37^NIG.12019R

(Lee et al., 2019)

abnormal DNA repair | adult stage | conditional, with mei-9^RNAi.UAS

(Mlih et al., 2018)

abnormal neuroanatomy | cell non-autonomous | third instar larval stage, with sotv^GD2025

(Poe et al., 2017)

abnormal neuroanatomy | cell non-autonomous | third instar larval stage, with ttv^GD1993

(Poe et al., 2017)

abnormal neuroanatomy | larval stage | conditional, with drpr^GD2628

(Han et al., 2014)

abnormal neuroanatomy | larval stage | conditional, with Scer\GAL4^I-76-D, dsb^GD2254

(Han et al., 2014)

abnormal neuroanatomy | larval stage | conditional, with Vps16A^RNAi.UAS.WIZ

(Han et al., 2014)

abnormal neuroanatomy | larval stage | conditional, with WASp^JF01975

(Han et al., 2014)

abnormal neuroanatomy | P-stage, with Alg1^GD9500

(Sung et al., 2024)

abnormal neuroanatomy | P-stage, with Alg1^HMC03502

(Sung et al., 2024)

abnormal neuroanatomy | P-stage, with Alg10^GLC01670

(Sung et al., 2024)

abnormal neuroanatomy | P-stage, with Alg10^HMS01159

(Sung et al., 2024)

abnormal neuroanatomy | third instar larval stage, with mav^GL01025

(Hoyer et al., 2018)

abnormal neuroanatomy | third instar larval stage, with mav^HMS01125

(Hoyer et al., 2018)

abnormal neuroanatomy | third instar larval stage, with mav^UAS.cGa

(Hoyer et al., 2018)

abnormal size | larval stage, with bsk^DN.UAS.cUa

(Lee et al., 2019)

abnormal size | larval stage, with Cdc37^NIG.12019R

(Lee et al., 2019)

abnormal size | larval stage, with Cdk2^HMS00174

(Lee et al., 2019)

abnormal size | larval stage, with CycE^HMS00060

(Lee et al., 2019)

abnormal size | third instar larval stage, with mav^GL01025

(Hoyer et al., 2018)

abnormal size | third instar larval stage, with mav^HMS01125

(Hoyer et al., 2018)

abnormal size | third instar larval stage, with mav^UAS.cGa

(Hoyer et al., 2018)

abnormal wound healing, with bsk^DN.UAS

(Galko and Krasnow, 2004)

abnormal wound healing | larval stage, with bsk^DN.UAS.cUa

(Lee et al., 2019)

abnormal wound healing | larval stage, with Cdc37^GD14633

(Lee et al., 2019)

abnormal wound healing | larval stage, with Cdc37^JF03184

(Lee et al., 2019)

abnormal wound healing | larval stage, with Cdc37^KK102575

(Lee et al., 2019)

abnormal wound healing | larval stage, with Cdc37^NIG.12019R

(Lee et al., 2019)

abnormal wound healing | P-stage, with Arp2^GD14716

(Rötte et al., 2024)

abnormal wound healing | P-stage, with Arp3^GD12273

(Rötte et al., 2024)

abnormal wound healing | P-stage, with cyri^GD8705

(Rötte et al., 2024)

abnormal wound healing | P-stage, with cyri^KK108589

(Rötte et al., 2024)

abnormal wound healing | P-stage, with cyri^UAS.cRa

(Rötte et al., 2024)

abnormal wound healing | P-stage, with SCAR^NIG.4636R

(Rötte et al., 2024)

decreased cell size | larval stage | conditional, with bsk^DN.UAS.cUa

(Lee et al., 2019)

decreased cell size | larval stage | conditional, with Cdc37^NIG.12019R

(Lee et al., 2019)

increased mortality during development | nutrition conditional, with Hpd^KK105686

(Kosakamoto et al., 2024)

lethal, with NijA^UAS.cBa

(Broderick et al., 2012)

some die during larval stage | nutrition conditional, with Hpd^KK105686

(Kosakamoto et al., 2024)

some die during P-stage | nutrition conditional, with Hpd^KK105686

(Kosakamoto et al., 2024)

viable, with Lgr4^JF03070

(Miao et al., 2024)

visible | adult stage | conditional, with mei-9^RNAi.UAS

(Mlih et al., 2018)

Phenotype Manifest In

adult abdomen | conditional, with mei-9^RNAi.UAS

(Mlih et al., 2018)

dendrite | P-stage, with Alg1^GD9500

(Sung et al., 2024)

dendrite | P-stage, with Alg1^HMC03502

(Sung et al., 2024)

dendrite | P-stage, with Alg10^GLC01670

(Sung et al., 2024)

dendrite | P-stage, with Alg10^HMS01159

(Sung et al., 2024)

dendrite | P-stage, with galectin^wgv

(Sung et al., 2024)

dendritic tree | cell non-autonomous | third instar larval stage, with sotv^GD2025

(Poe et al., 2017)

dendritic tree | cell non-autonomous | third instar larval stage, with ttv^GD1993

(Poe et al., 2017)

dendritic tree | third instar larval stage, with mav^GL01025

(Hoyer et al., 2018)

dendritic tree | third instar larval stage, with mav^HMS01125

(Hoyer et al., 2018)

dendritic tree | third instar larval stage, with mav^UAS.cGa

(Hoyer et al., 2018)

distal dendrite | cell non-autonomous | third instar larval stage, with sotv^GD2025

(Poe et al., 2017)

embryonic/larval epidermis | larval stage, with bsk^DN.UAS.cUa

(Lee et al., 2019)

embryonic/larval epidermis | larval stage, with Cdc37^NIG.12019R

(Lee et al., 2019)

embryonic/larval epidermis | larval stage | conditional, with bsk^DN.UAS.cUa

(Lee et al., 2019)

embryonic/larval epidermis | larval stage | conditional, with Cdc37^GD14633

(Lee et al., 2019)

embryonic/larval epidermis | larval stage | conditional, with Cdc37^JF03184

(Lee et al., 2019)

embryonic/larval epidermis | larval stage | conditional, with Cdc37^KK102575

(Lee et al., 2019)

embryonic/larval epidermis | larval stage | conditional, with Cdc37^NIG.12019R

(Lee et al., 2019)

embryonic/larval plasmatocyte | P-stage, with cyri^UAS.cRa

(Rötte et al., 2024)

lamellipodium | P-stage, with Arp2^GD14716

(Rötte et al., 2024)

lamellipodium | P-stage, with Arp3^GD12273

(Rötte et al., 2024)

lamellipodium | P-stage, with SCAR^NIG.4636R

(Rötte et al., 2024)

larval dorsal multidendritic neuron ddaB | cell non-autonomous | third instar larval stage, with ttv^GD1993

(Poe et al., 2017)

larval dorsal multidendritic neuron ddaC | larval stage | conditional, with drpr^GD2628

(Han et al., 2014)

larval dorsal multidendritic neuron ddaC | larval stage | conditional, with Scer\GAL4^I-76-D, dsb^GD2254

(Han et al., 2014)

larval dorsal multidendritic neuron ddaC | larval stage | conditional, with Vps16A^RNAi.UAS.WIZ

(Han et al., 2014)

larval dorsal multidendritic neuron ddaC | larval stage | conditional, with WASp^JF01975

(Han et al., 2014)

larval dorsal multidendritic neuron ddaC | P-stage, with Alg1^GD9500

(Sung et al., 2024)

larval dorsal multidendritic neuron ddaC | P-stage, with Alg1^HMC03502

(Sung et al., 2024)

larval dorsal multidendritic neuron ddaC | P-stage, with Alg10^GLC01670

(Sung et al., 2024)

larval dorsal multidendritic neuron ddaC | P-stage, with Alg10^HMS01159

(Sung et al., 2024)

larval dorsal multidendritic neuron ddaD | cell non-autonomous | third instar larval stage, with ttv^GD1993

(Poe et al., 2017)

larval dorsal multidendritic neuron ddaE | cell non-autonomous | third instar larval stage, with ttv^GD1993

(Poe et al., 2017)

larval multidendritic class IV neuron | cell non-autonomous | third instar larval stage, with sotv^GD2025

(Poe et al., 2017)

larval multidendritic class IV neuron | cell non-autonomous | third instar larval stage, with ttv^GD1993

(Poe et al., 2017)

larval multidendritic class IV neuron | third instar larval stage, with mav^GL01025

(Hoyer et al., 2018)

larval multidendritic class IV neuron | third instar larval stage, with mav^HMS01125

(Hoyer et al., 2018)

larval multidendritic class IV neuron | third instar larval stage, with mav^UAS.cGa

(Hoyer et al., 2018)

nucleus | larval stage, with bsk^DN.UAS.cUa

(Lee et al., 2019)

nucleus | larval stage, with Cdc37^NIG.12019R

(Lee et al., 2019)

nucleus | larval stage, with Cdk2^HMS00174

(Lee et al., 2019)

nucleus | larval stage, with CycE^HMS00060

(Lee et al., 2019)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^A58, sotv^GD2025 has abnormal neuroanatomy | third instar larval stage | cell non-autonomous phenotype, enhanceable by Ptp69D^CRISPR.14/Df(3L)8ex34

(Poe et al., 2017)

NOT Enhanced by

Statement

Reference

SCAR^NIG.4636R, Scer\GAL4^A58 has abnormal wound healing | P-stage phenotype, non-enhanceable by Scer\GAL4^unspecified/cyri^KK108589

(Rötte et al., 2024)

Suppressed by

Statement

Reference

Cdc37^NIG.12019R, Scer\GAL4^A58 has abnormal wound healing | larval stage phenotype, suppressible by Dmoj\Cdc37^UAS.cLa, Scer\GAL4^A58

(Lee et al., 2019)

Scer\GAL4^A58, mav^UAS.cGa has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by Ret^ko

(Hoyer et al., 2018)

Scer\GAL4^A58, mav^UAS.cGa has abnormal size | third instar larval stage phenotype, suppressible by Ret^ko

(Hoyer et al., 2018)

NOT suppressed by

Statement

Reference

SCAR^NIG.4636R, Scer\GAL4^A58 has abnormal wound healing | P-stage phenotype, non-suppressible by Scer\GAL4^unspecified/cyri^KK108589

(Rötte et al., 2024)

Cdc37^NIG.12019R, Scer\GAL4^A58 has abnormal wound healing | larval stage phenotype, non-suppressible by Jra^UAS.cUa, Scer\GAL4^A58

(Lee et al., 2019)

Scer\GAL4^A58, mei-9^RNAi.UAS has abnormal DNA repair | adult stage | conditional phenotype, non-suppressible by Ercc1^KK101553, Scer\GAL4^A58

(Mlih et al., 2018)

Enhancer of

Statement

Reference

sotv^GD2025/Scer\GAL4^A58 is an enhancer of abnormal neuroanatomy | third instar larval stage phenotype of Ptp69D^CRISPR.14/Df(3L)8ex34

(Poe et al., 2017)

Suppressor of

Statement

Reference

Dmoj\Cdc37^UAS.cLa, Scer\GAL4^A58 is a suppressor of abnormal wound healing | larval stage phenotype of Cdc37^NIG.12019R, Scer\GAL4^A58

(Lee et al., 2019)

NOT Suppressor of

Statement

Reference

ctg^UAS.mRFP1/Scer\GAL4^A58 is a non-suppressor of abnormal neuroanatomy | P-stage phenotype of ctg^wgd, galectin^wgv

(Sung et al., 2024)

galectin^UAS.mRFP1/Scer\GAL4^A58 is a non-suppressor of abnormal neuroanatomy | P-stage phenotype of ctg^wgd, galectin^wgv

(Sung et al., 2024)

Jra^UAS.cUa, Scer\GAL4^A58 is a non-suppressor of abnormal wound healing | larval stage phenotype of Cdc37^NIG.12019R, Scer\GAL4^A58

(Lee et al., 2019)

Ercc1^KK101553, Scer\GAL4^A58 is a non-suppressor of abnormal DNA repair | adult stage | conditional phenotype of Scer\GAL4^A58, mei-9^RNAi.UAS

(Mlih et al., 2018)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^A58, sotv^GD2025 has larval multidendritic class IV neuron | third instar larval stage | cell non-autonomous phenotype, enhanceable by Ptp69D^CRISPR.14/Df(3L)8ex34

(Poe et al., 2017)

Scer\GAL4^A58, sotv^GD2025 has dendritic tree | third instar larval stage | cell non-autonomous phenotype, enhanceable by Ptp69D^CRISPR.14/Df(3L)8ex34

(Poe et al., 2017)

Scer\GAL4^A58, sotv^GD2025 has distal dendrite | third instar larval stage | cell non-autonomous phenotype, enhanceable by Ptp69D^CRISPR.14/Df(3L)8ex34

(Poe et al., 2017)

NOT Enhanced by

Statement

Reference

SCAR^NIG.4636R, Scer\GAL4^A58 has lamellipodium | P-stage phenotype, non-enhanceable by Scer\GAL4^unspecified/cyri^KK108589

(Rötte et al., 2024)

Suppressed by

Statement

Reference

Cdc37^NIG.12019R, Scer\GAL4^A58 has embryonic/larval epidermis | larval stage | conditional phenotype, suppressible by Dmoj\Cdc37^UAS.cLa, Scer\GAL4^A58

(Lee et al., 2019)

Scer\GAL4^A58, mav^UAS.cGa has larval multidendritic class IV neuron | third instar larval stage phenotype, suppressible by Ret^ko

(Hoyer et al., 2018)

Scer\GAL4^A58, mav^UAS.cGa has dendritic tree | third instar larval stage phenotype, suppressible by Ret^ko

(Hoyer et al., 2018)

NOT suppressed by

Statement

Reference

SCAR^NIG.4636R, Scer\GAL4^A58 has lamellipodium | P-stage phenotype, non-suppressible by Scer\GAL4^unspecified/cyri^KK108589

(Rötte et al., 2024)

Cdc37^NIG.12019R, Scer\GAL4^A58 has embryonic/larval epidermis | larval stage | conditional phenotype, non-suppressible by Jra^UAS.cUa, Scer\GAL4^A58

(Lee et al., 2019)

Scer\GAL4^A58, mei-9^RNAi.UAS has adult abdomen | conditional phenotype, non-suppressible by Ercc1^KK101553, Scer\GAL4^A58

(Mlih et al., 2018)

Enhancer of

Statement

Reference

sotv^GD2025/Scer\GAL4^A58 is an enhancer of larval multidendritic class IV neuron | third instar larval stage phenotype of Ptp69D^CRISPR.14/Df(3L)8ex34

(Poe et al., 2017)

sotv^GD2025/Scer\GAL4^A58 is an enhancer of dendritic tree | third instar larval stage phenotype of Ptp69D^CRISPR.14/Df(3L)8ex34

(Poe et al., 2017)

sotv^GD2025/Scer\GAL4^A58 is an enhancer of distal dendrite | third instar larval stage phenotype of Ptp69D^CRISPR.14/Df(3L)8ex34

(Poe et al., 2017)

Suppressor of

Statement

Reference

Dmoj\Cdc37^UAS.cLa, Scer\GAL4^A58 is a suppressor of embryonic/larval epidermis | larval stage | conditional phenotype of Cdc37^NIG.12019R, Scer\GAL4^A58

(Lee et al., 2019)

NOT Suppressor of

Statement

Reference

galectin^UAS.mRFP1/Scer\GAL4^A58 is a non-suppressor of dendrite | P-stage phenotype of ctg^wgd, galectin^wgv

(Sung et al., 2024)

ctg^UAS.mRFP1/Scer\GAL4^A58 is a non-suppressor of larval dorsal multidendritic neuron ddaC | P-stage phenotype of ctg^wgd, galectin^wgv

(Sung et al., 2024)

ctg^UAS.mRFP1/Scer\GAL4^A58 is a non-suppressor of dendrite | P-stage phenotype of ctg^wgd, galectin^wgv

(Sung et al., 2024)

galectin^UAS.mRFP1/Scer\GAL4^A58 is a non-suppressor of larval dorsal multidendritic neuron ddaC | P-stage phenotype of ctg^wgd, galectin^wgv

(Sung et al., 2024)

Jra^UAS.cUa, Scer\GAL4^A58 is a non-suppressor of embryonic/larval epidermis | larval stage | conditional phenotype of Cdc37^NIG.12019R, Scer\GAL4^A58

(Lee et al., 2019)

Ercc1^KK101553, Scer\GAL4^A58 is a non-suppressor of adult abdomen | conditional phenotype of Scer\GAL4^A58, mei-9^RNAi.UAS

(Mlih et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

drpr^UAS.cSa.EGFP/Scer\GAL4^A58 rescues drpr^Δ5

(Sung et al., 2024)

Alg10^UAS.cSa/Scer\GAL4^A58 rescues Alg10^wgd

(Sung et al., 2024)

Sema2b^UAS.cUa/Scer\GAL4^A58 rescues Sema2b^f02042/Df(2R)Sema2b-C4

(Meltzer et al., 2016)

Sema2b^{UAS.GFP,Tag:M(mCd8a)}/Scer\GAL4^A58 rescues Sema2b^f02042/Df(2R)Sema2b-C4

(Meltzer et al., 2016)

ERR^UAS.cTa/Scer\GAL4^A58 rescues ERR²/ERR¹

(Tennessen et al., 2011)

Fails to rescue

drpr^NQ4.UAS.EGFP/Scer\GAL4^A58 fails to rescue drpr^Δ5

(Sung et al., 2024)

path^A.UAS.GFP/Scer\GAL4^A58 fails to rescue path^dg50/Df(3L)BSC773

(Lin et al., 2015)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

GAL4^58A

(Alizzi et al., 2020)

Gal4^A58

(Poe et al., 2017, Meltzer et al., 2016)

Scer\GAL4^A58

Name Synonyms

Secondary FlyBase IDs

References (43)

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