Allele Dmel\Nos^C

General Information
Symbol	Dmel\Nos^C	Species	D. melanogaster
Name		FlyBase ID	FBal0182479
Feature type	allele	Associated gene	Dmel\Nos
Also Known As	dNOS^C

Map ( GBrowse )
Allele class	amorphic allele - molecular evidence
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	amorphic allele - molecular evidence (Yakubovich et al., 2010)
Mutagen	ethyl methanesulfonate (Regulski et al., 2004)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 2L:10,816,228..10,816,228 evidence=experimental na_change=G10816228A pr_change=G584E\|Nos-PI,G584E\|Nos-PJ,G584E\|Nos-PB,G584E\|N os-PC,G479E\|Nos-PE,G584E\|Nos-PF,G584E\|Nos-PG,G584E\|Nos-PH, G584E\|Nos-PA reported_na_change=G?A reported_pr_change=G585E (Regulski et al., 2004)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: G585E. (Regulski et al., 2004) Nucleotide substitution: G1942A. (Regulski et al., 2004)
Cytology
Phenotypic Data
Phenotypic Class
	viable (Yakubovich et al., 2010) viable (with Nos^Δ15) (Yakubovich et al., 2010)
Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer
	Separable from: a secondary lethal mutation on the chromosome, which maps roughly 0.08 map units (approximately 22kb) from the Nos[C] lesion. (Yakubovich et al., 2010) FlyBase curator comment: FBrf0210138 demonstrates that the lethality attributed to the Nos[C] mutation in FBrf0180083 is in fact due to a separable second-site lethal on the chromosome. (Regulski et al., 2004)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	dNOS^C (Regulski et al., 2004, Pilgram et al., 2011) Nos^C (Yakubovich et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Pilgram et al., 2011, J. Neurosci. 31(2): 492--500 The RhoGAP crossveinless-c Interacts with Dystrophin and Is Required for Synaptic Homeostasis at the Drosophila Neuromuscular Junction. [FBrf0212767]
Review	Regulski et al., 2004, Curr. Biol. 14(20): R881--R882 Essential function of nitric oxide synthase in Drosophila. [FBrf0180083]
Letter	Yakubovich et al., 2010, Curr. Biol. 20(4): R141--R142 Nitric oxide synthase is not essential for Drosophila development. [FBrf0210138]

Allele Dmel\NosC

Allele Dmel\Nos^C