Allele Dmel\Mrtf^{ΔN.H.Scer\UAS}

General Information
Symbol	Dmel\Mrtf^{ΔN.H.Scer\UAS}	Species	D. melanogaster
Name		FlyBase ID	FBal0182631
Feature type	allele	Associated gene	Dmel\Mrtf

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - deletion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - deletion (Han et al., 2004) in vitro construct - regulatory fusion (Han et al., 2004)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Scer\UAS regulatory sequences drive expression of a hyperactive form of Mrtf, in which the inhibitory N-terminal domain has been deleted. (Han et al., 2004)
Carried in construct	P{UAS-Mrtf.ΔN.H} (Han et al., 2004)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	cardioblast, with Scer\GAL4^how-24B, Scer\GAL4^twi.PG (Han et al., 2004) dorsal branch primordium, with Scer\GAL4^btl.PS (Han et al., 2004) embryonic dorsal vessel, with Scer\GAL4^how-24B, Scer\GAL4^twi.PG (Han et al., 2004) embryonic somatic muscle, with Scer\GAL4^how-24B, Scer\GAL4^twi.PG (Han et al., 2004) ganglionic branch primordium, with Scer\GAL4^btl.PS (Han et al., 2004) mesoderm, with Scer\GAL4^da.G32 (Han et al., 2004) mesoderm, with Scer\GAL4^how-24B, Scer\GAL4^twi.PG (Han et al., 2004) presumptive embryonic/larval tracheal system, with Scer\GAL4^da.G32 (Han et al., 2004)
Detailed Description
	Statement Reference When Mrtf^{ΔN.H.Scer\UAS} is expressed under the control of both Scer\GAL4^twi.PG and Scer\GAL4^how-24B together, excessive migration of the mesoderm is seen in developing embryos. This results in disruption of the segmentally distributed muscle pattern in stage 14 embryos; large groups of muscle cells are clustered and located more dorsally than normal, and there are obvious gaps in the ventral lateral region. In stage 16 embryos, the cardiac cells are misaligned and they do not form a heart tube. Expression of Mrtf^{ΔN.H.Scer\UAS} under the control of Scer\GAL4^btl.PS results in defects in the tracheal system in embryos; abnormally long dorsal branches are often seen on the dorsal side of the embryo, whereas the extension of the ganglionic branches is undirectional and enhanced. Expression of Mrtf^{ΔN.H.Scer\UAS} under the control of Scer\GAL4^da.G32 in embryos results in a disruption of the patterning of the tracheal system associated with excessive and unpatterned branches. Defects in mesoderm migration are also seen in these embryos. (Han et al., 2004)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Mrtf^{ΔN.H.Scer\UAS}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Han et al., 2004, Proc. Natl. Acad. Sci. U.S.A. 101(34): 12567--12572 A myocardin-related transcription factor regulates activity of serum response factor in Drosophila. [FBrf0180628]

Allele Dmel\MrtfΔN.H.Scer\UAS

Allele Dmel\Mrtf^{ΔN.H.Scer\UAS}