Allele Dmel\Lk6^EP30.18

General Information
Symbol	Dmel\Lk6^EP30.18	Species	D. melanogaster
Name		FlyBase ID	FBal0182925
Feature type	allele	Associated gene	Dmel\Lk6

Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P{EP} insertion approximately 1950bp upstream of the Lk6 open reading frame encoding the shorter isoform. (Reiling et al., 2005)
Caused by insertion	P{EP}Lk6^EP30.18 (Reiling et al., 2005)
Cytology
Phenotypic Data
Phenotypic Class
	decreased cell number, with Scer\GAL4^da.G32 (Reiling et al., 2005) lethal, with Scer\GAL4^Act5C.PU (Reiling et al., 2005) small body, with Scer\GAL4^da.G32 (Reiling et al., 2005)
Phenotype Manifest In
	wing, with Scer\GAL4^da.G32 (Reiling et al., 2005)
Detailed Description
	Statement Reference Flies expressing Lk6^EP30.18 under the control of Scer\GAL4^da.G32 are smaller than normal (weight reduction compared to controls is 10% in females and 9% in males). The wings of these flies are smaller than normal, and this is caused by a decrease in cell number, but not in cell size. The weight reduction caused by overexpression of Lk6^EP30.18 under the control of Scer\GAL4^da.G32 is diminished by reducing the yeast content of the food. The lethality caused by overexpression of Lk6^EP30.18 under the control of Scer\GAL4^Act5C is substantially suppressed if the animals are reared on low yeast food. Under starvation conditions, flies expressing Lk6^EP30.18 under the control of Scer\GAL4^da.G32 show an extension of lifespan compared to controls. (Reiling et al., 2005)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Lk6^EP30.18, Scer\GAL4^da.G32 has small body phenotype, suppressible by eIF-4E^S058911/eIF-4E^{Ser251Ala.t8.9}, Scer\GAL4^da.G32 (Reiling et al., 2005)
Suppressor of
Statement Reference Lk6^EP30.18 is a suppressor of large body phenotype of Akt1^Scer\UAS.cRa, Pdk1^EP837, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Reiling et al., 2005)
Phenotype Manifest In
Suppressor of
Statement Reference Lk6^EP30.18 is a suppressor of eye phenotype of Akt1^Scer\UAS.cRa, Pdk1^EP837, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Reiling et al., 2005) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, Lk6^EP30.18 is a suppressor of eye phenotype of Akt1^Scer\UAS.cRa, Pdk1^EP837, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Reiling et al., 2005)
Additional Comments
Genetic Interactions
Statement Reference Animals expressing both Akt1^Scer\UAS.cRa and Pk61C^EP837 under the control of Scer\GAL4^GMR.PF have a large-eye phenotype. Expression of Lk6^EP30.18 in this background strongly suppresses this phenotype. The small body phenotype caused by expression of Lk6^EP30.18 under the control of Scer\GAL4^da.G32 is not seen if the flies are also expressing eIF-4E^{Ser251Ala.t8.9} in a eIF-4E^S058911/eIF-4E^S058911 background. (Reiling et al., 2005)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Lk6^EP30.18
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Reiling et al., 2005, Curr. Biol. 15(1): 24--30 Diet-dependent effects of the Drosophila Mnk1/Mnk2 homolog Lk6 on growth via eIF4E. [FBrf0183826]

Allele Dmel\Lk6EP30.18

Allele Dmel\Lk6^EP30.18