Allele Dmel\Hph^Scer\UAS.cFa

General Information
Symbol	Dmel\Hph^Scer\UAS.cFa	Species	D. melanogaster
Name		FlyBase ID	FBal0183285
Feature type	allele	Associated gene	Dmel\Hph

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Frei et al., 2005, Frei and Edgar, 2004)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Scer\UAS sequences drive expression of Hph. (Frei et al., 2005) Construct: Expression of a XhoI BglII fragment of full length Hph cDNA (GH23732) is under the control of Scer\UAS sequences. (Frei and Edgar, 2004)
Carried in construct	P{UAS-Hph.F} (Frei and Edgar, 2004, Frei et al., 2005)
Cytology
Phenotypic Data
Phenotypic Class
	cell growth defective \| somatic clone, with Scer\GAL4^Act5C.PP (Frei et al., 2005) size defective \| somatic clone, with Scer\GAL4^Act5C.PP (Frei and Edgar, 2004)
Phenotype Manifest In

Detailed Description
	Statement Reference Clonal expression of Hph^Scer\UAS.cFa leads to an overgrowth phenotype. (Frei et al., 2005) Somatic clones of Hph^Scer\UAS.cFa; Scer\GAL4^Act5C.PP in the late third instar wing disc are larger than twinspot control clones. (Frei and Edgar, 2004)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Hph^Scer\UAS.cFa, Scer\GAL4^Act5C.PP has cell growth defective \| somatic clone phenotype, suppressible by mRpL12¹⁰⁵³⁴ (Frei et al., 2005)
NOT suppressed by
Statement Reference Hph^Scer\UAS.cFa, Scer\GAL4^Act5C.PP has size defective \| somatic clone phenotype, non-suppressible by Cdk4³ (Frei and Edgar, 2004)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference When Hph^Scer\UAS.cFa is driven in a Scer\GAL4^Act5C.PP background no extra growth is seen. (Frei et al., 2005) Overgrowth of Hph^Scer\UAS.cFa; Scer\GAL4^Act5C.PP somatic clones in third instar wing discs is unaffected by Cdk4³/Cdk4³. (Frei and Edgar, 2004)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	Hph^Scer\UAS.cFa/Scer\GAL4^hs.PB rescues Hph^S030304/Hph⁰²²⁵⁵ (Frei and Edgar, 2004)
Comments	P{UAS-Hph.F}II.1; P{UAS-Hph.F}II.2; Scer\GAL4^hs.PB rescues the lethality of Hph⁰²²⁵⁵/Hph^S030304 even in the absence of heat shock. Hph^Scer\UAS.cFa rescues the increase in ommatidial size in Cdk4^Scer\UAS.cMa; CycD^Scer\UAS.cDa; Scer\GAL4^GMR.PF suppressed by Hph⁰²²⁵⁵/+ or Hph^S030304/+. (Frei and Edgar, 2004)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Hph^Scer\UAS.cFa
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Frei et al., 2005, EMBO J. 24(3): 623--634 The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth. [FBrf0183949] Frei and Edgar, 2004, Dev. Cell 6(2): 241--251 Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth. [FBrf0174538]

Allele Dmel\HphScer\UAS.cFa

Allele Dmel\Hph^Scer\UAS.cFa