FB2025_01 , released February 20, 2025
Allele: Dmel\HGTXUAS.cBa
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General Information
Symbol
Dmel\HGTXUAS.cBa
Species
D. melanogaster
Name
FlyBase ID
FBal0183332
Feature type
allele
Associated gene
Dmel\HGTX
Associated Insertion(s)
Carried in Construct
P{UAS-HGTX.B}
Also Known As
UAS-nkx6
Key Links
Transgenic product class
cDNA
(Broihier et al., 2004)
wild_type
(Broihier et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Broihier et al., 2004)
wild_type
(Broihier et al., 2004)
Mutagen
in vitro construct
(Skeath, 2007.3.20, Broihier et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-HGTX.B}
Cytology
Description

UASt sequences control the expression of HGTX cDNA.

(Broihier et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
HGTX
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of HGTXScer\UAS.cBa under the control of Scer\GAL4elav-C155 has no effect on embryonic lateral fd59A[+] neurons, but occasional extra medial fd59A neurons are seen.

      (Lacin et al., 2014)

      A lineage 3 postembryonic neuroblast clone expressing HGTXScer\UAS.cBa under the control of Scer\GAL4elav-C155 and examined at the third larval instar stage contains the 3il axon bundle, but lacks the 3id bundle normally produced by this lineage in 40% of cases, and has a reduced 3id bundle in the remainder.

      (Lacin et al., 2014)

      The overall pattern and thickness of ventral motor axon projections (including ISNb) is normal in HGTXScer\UAS.cBa(x2); Scer\GAL4elav.PLu embryos. However, a significant proportion of ISNb axons in the embryos have overgrowth phenotypes such as an expanded terminal arbor or excessive axonal branching and extension and fusion across the segment boundary of adjacent segments.

      (Broihier et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      NOT Suppressor of
      Phenotype Manifest In
      NOT Enhancer of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of HGTXScer\UAS.cBa does not alter the ectopic lateral fd59A[+] neurons seen when exexScer\UAS.cBa is expressed under the control of Scer\GAL4elav-C155.

      (Lacin et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4HGTX-GAL4/HGTXUAS.cBa partially rescues HGTXGAL4/HGTXD25

      (Broihier et al., 2004)
      Comments

      HGTXScer\UAS.cBa partially rescues formation of formation of secondary branches of the intersegmental nerve (anterior fascicle), ISNb and ISNd, in HGTXD25/HGTXGAL4 embryos.

      (Broihier et al., 2004)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      HGTXScer\UAS.cBa
      HGTXUAS.cBa
      Name Synonyms
      Secondary FlyBase IDs
        References (7)