Allele Dmel\H15^nmr-210

General Information
Symbol	Dmel\H15^nmr-210	Species	D. melanogaster
Name		FlyBase ID	FBal0183343
Feature type	allele	Associated gene	Dmel\H15
Also Known As	nmr1²¹⁰

Allele class	loss of function allele
Mutagen	Delta2-3
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	loss of function allele (Qian et al., 2005, Leal et al., 2009)
Mutagen	Delta2-3 (Qian et al., 2005)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{PZ}H-15 (Qian et al., 2005)
Nature of the lesion	Statement Reference Imprecise excision of the P{PZ} element, resulting in a 10911bp deletion of H15, from -331bp to +10580bp, which the 5'UTR, transcription and translation start sites and the entire DNA binding domain. (Qian et al., 2005)
Cytology
Phenotypic Data
Phenotypic Class
	viable (Qian et al., 2005)
Phenotype Manifest In

Detailed Description
	Statement Reference Neuronal cell fate specification progresses normally in the central nervous system of homozygous H15[nmr-210] embryos. (Leal et al., 2009)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference Embryos doubly mutant for H15[nmr-210] and exex[KK30] do not show enhancement of the respective single mutant central nervous system phenotypes. (Leal et al., 2009)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	H15^nmr-210 nmr1²¹⁰ (Leal et al., 2009, Qian et al., 2008)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Leal et al., 2009, Dev. Biol. 325(1): 138--150 Neuromancer1 and Neuromancer2 regulate cell fate specification in the developing embryonic CNS of Drosophila melanogaster. [FBrf0207072] Qian et al., 2008, Proc. Natl. Acad. Sci. U.S.A. 105(50): 19833--19838 Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease. [FBrf0206565] Qian et al., 2005, Dev. Biol. 279(2): 509--524 Neuromancer Tbx20-related genes (H15/midline) promote cell fate specification and morphogenesis of the Drosophila heart. [FBrf0183861]

Allele Dmel\H15nmr-210

Allele Dmel\H15^nmr-210