FB2025_01 , released February 20, 2025
Allele: Dmel\GαsW24.UAS
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General Information
Symbol
Dmel\GαsW24.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0183474
Feature type
allele
Associated gene
Dmel\Gαs
Associated Insertion(s)
Carried in Construct
P{UAS-Gαs.W24}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Hou et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-Gαs.W24}
Cytology
Description

UAS sequences drive expression of Gαs.

(Hou et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Gαs
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      GαsW24.UAS/Scer\GAL4elav.PLu partially rescues GαsR60

      (Hou et al., 2003)
      Fails to rescue

      Scer\GAL4Mhc.PW/GαsW24.UAS fails to rescue GαsR60

      (Hou et al., 2003)
      Comments

      Expression of G-sα60AW24.Scer\UAS in neurons, driven by Scer\GAL4elav.PLu, restores many synaptic defects in G-sα60AR60 embryos. One notable exception is that post-tetanic potentiation is not as strong as that observed in heterozygous G-sα60AR60 embryos. In contrast, when G-sα60AW24.Scer\UAS is expressed in muscle, driven by Scer\GAL4Mhc.PW, it completely fails to rescue the synaptic impairment seen in G-sα60AR60 embryos.

      (Hou et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      G-sα60AW24.Scer\UAS
      GαsW24.Scer\UAS
      GαsW24.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)