FlyBase Allele Report: Dmel\Dop1R1[f02676]

(Noyes and Davis, 2023, Mohandasan et al., 2022, Jia et al., 2021, Honegger et al., 2020, Awata et al., 2019, Stern et al., 2019, Shyu et al., 2017, Ueno et al., 2017, Jiang et al., 2016, Cassar et al., 2015, Kottler et al., 2013, Li et al., 2013, Inagaki et al., 2012, Liu et al., 2012, Kong et al., 2010, Kim et al., 2007, Gene Disruption Project members and Exelixis, 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Dop1R1^f02676 homozygous mutant adults do not have an increase in aversive olfactory 24 h memory observed when the recall environment better matches the training environment (presence of copper grid) unlike controls.

(Zhao et al., 2019)

Dop1R1^f02676 heterozygous larvae have a shift in odor-induced increases in mouth hook contractions towards higher concentrations of odorants, compared to controls.

(Pu et al., 2018)

Dop1R1^f02676 homozygous adults show an apparently normal sensitivity to ethanol as compared to controls: they shown an apparently normal time until sedation and a normal tolerance development following daily exposures; they also show normal ethanol-induced disinhibition, as shown by the increasing frequency of inter-male courtship upon continual exposure.

(Aranda et al., 2017)

Dop1R1^f02676 mutant adults have significantly reduced 24-hour associative olfactory water-reward memory, compared to controls, with no alteration in odor acuity or water preference.

(Shyu et al., 2017)

Dop1R1^f02676 mutant flies do not show increased resistance to paraquat intoxication compared to controls.

(Cassar et al., 2015)

Dop1R1[f02676] adults have significantly impaired long-term, but not short-term, appetitive olfactory memory, compared to controls.

(Ichinose et al., 2015)

Dop1R1^f02676 mutants exhibit significantly impaired water learning.

(Lin et al., 2014)

In contrast to wild type controls, rapamycin does not affect night activity, night sleep, night sleep bout number or bout duration in Dop1R1^f02676 mutants.

(Metaxakis et al., 2014)

Dop1R1^f02676 mutant adults have significantly reduced aversive and appetitive 1-min visual memory, compared to controls and significantly altered naive electric shock, but not sugar preference, compared to controls.

(Vogt et al., 2014)

Homozygous flies show a severe defect in long-term olfactory memory measured 24 hours after spaced repetitive training.

Expression of DopR^Scer\UAS.cKa under the control of Scer\GAL4^ey-OK107 in a homozygous DopR^f02676 background (which will also result in the expression of DopR from the Scer\UAS regulatory sequences present in the insertion in DopR^f02676) results in a severe defect in long-term olfactory memory measured 24 hours after spaced repetitive training.

(Li et al., 2013)

DopR^f02676 mutant flies show a similar increase in sugar sensitivity in response to L-Dopa feeding to wild controls.

(Inagaki et al., 2012)

The decreased night-time sleep seen when wild-type flies are fed L-dopa is markedly suppressed in a DopR^f02676/DopR^f02676 background.

(Liu et al., 2012)

Dop1R1^f02676 mutant adults have significantly reduced associative appetitive olfactory memory, compared to controls.

(Liu et al., 2012)

DopR^f02676 mutants show reduced ethanol-induced hyperactivity and no change in ethanol sedation sensitivity or ethanol absorption. DopR^f02676 also show increased activity prior to ethanol exposure.

DopR^f02676/Df(3R)ED5634 flies show reduced ethanol-induced hyperactivity.

DopR^f02676 mutants perform indistinguishably from wild-type in a rapid tolerance paradigm, showing both increased ethanol-induced hyperactivity and increased resistance to the sedating effects of ethanol during a second exposure to ethanol vapor.

(Kong et al., 2010)

Dop1R1^f02676 mutant larvae show a significantly reduced performance in aversive and appetitive olfactory learning (using amylacetate (AM) and benzaldehyde (BA)) compared to controls. Perception of AM and BA, salt and sugar are all similar to wild type.

(Selcho et al., 2009)

DopR^f02676/DopR^f02676 and DopR^f02676/In(3LR)234 adults fail to learn to avoid specific odors after conditioning by concurrent shock and odor exposure. The same results are seen when testing is done immediately after conditioning or 1 hour after conditioning and with a variety of odors. These animals also have significantly reduced scores in tests for sugar reward mediated olfactory conditioning.

(Kim et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Scer\GAL4^Mef2.247/Dop1R1^f02676 is a non-enhancer of abnormal memory | adult stage | heat sensitive phenotype of Ecol\lexA^GMR58E02, TrpA1^{13xlexAop.JFRC26}

(Liu et al., 2012)

Suppressor of

Statement

Reference

Dop1R1^f02676 is a suppressor | partially of abnormal locomotor behavior | adult stage | conditional phenotype of Cnoc\ChR1::Csub\ChR^{CsChrimson.IVS.20xUAS.Venus}, Scer\GAL4^0273-G4

(Stern et al., 2019)

DopR[+]/Dop1R1^f02676 is a suppressor of abnormal chemosensory behavior phenotype of mir-276a^Rosa/mir-276a^D8

(Li et al., 2013)

Dop1R1^f02676/Dop1R1^f02676 is a suppressor of abnormal sleep | heat sensitive phenotype of Scer\GAL4^ple.PF, TrpA1^UAS.(B).cKa

(Liu et al., 2012)

Dop1R1^f02676 is a suppressor of abnormal memory | adult stage | heat sensitive phenotype of Ecol\lexA^GMR58E02, TrpA1^{13xlexAop.JFRC26}

(Liu et al., 2012)

NOT Suppressor of

Statement

Reference

Dop1R1^f02676 is a non-suppressor of abnormal sleep phenotype of Df(3L)Ilp2-3, Ilp5¹

(Metaxakis et al., 2014)

Scer\GAL4^Mef2.247/Dop1R1^f02676 is a non-suppressor of abnormal memory | adult stage | heat sensitive phenotype of Ecol\lexA^GMR58E02, TrpA1^{13xlexAop.JFRC26}

(Liu et al., 2012)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Dop1R1^f02676 does not suppress the activity and sleep defects seen in Df(3L)Ilp2-3, Ilp5¹ mutant flies.

(Metaxakis et al., 2014)

DopR^f02676/+ suppresses the defect in naive odour avoidance response to 4-methylcyclohexanol (1 x 10[-3] v/v) which is seen in mir-276a^Rosa/mir-276a^D8 flies.

(Li et al., 2013)

The reduction in nighttime sleep seen in flies expressing TrpA1^{Scer\UAS.(B).cKa} under the control of Scer\GAL4^ple.PF at 27[o]C is fully suppressed by Dop1R1^f02676/Dop1R1^f02676.

(Liu et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Dop1R1^f02676 is rescued by Dop1R1^f02676/Scer\GAL4^VT057244

(Shyu et al., 2017)

Dop1R1^f02676 is rescued by Scer\GAL4^Mef2.247/Dop1R1^UAS.cLa

(Ichinose et al., 2015)

Dop1R1^f02676 is rescued by Dop1R1^UAS.cLa/Scer\GAL4^NP1131

(Lin et al., 2014)

Dop1R1^f02676 is rescued by Scer\GAL4^Tab2-201Y/Dop1R1^UAS.cLa

(Lin et al., 2014)

Dop1R1^f02676 is rescued by Dop1R1^f02676/Scer\GAL4^Gr5a.8.5

(Inagaki et al., 2012)

Dop1R1^f02676 is rescued by Scer\GAL4^Mef2.247/Dop1R1^f02676

(Liu et al., 2012)

Dop1R1^f02676 is rescued by Dop1R1^UAS.cKa/Scer\GAL4^5.30

(Kong et al., 2010)

Dop1R1^f02676 is rescued by Dop1R1^UAS.cKa/Scer\GAL4^11.148

(Kong et al., 2010)

Dop1R1^f02676 is rescued by Dop1R1^UAS.cKa/Scer\GAL4^lilli-189Y

(Kong et al., 2010)

Dop1R1^f02676 is rescued by Scer\GAL4^Mef2.247/Dop1R1^f02676

(Kim et al., 2007)

In(3LR)234/Dop1R1^f02676 is rescued by Scer\GAL4^Mef2.247/Dop1R1^f02676

(Kim et al., 2007)

Partially rescued by

Dop1R1^f02676 is partially rescued by Scer\GAL4^Mef2.247/Dop1R1^f02676

(Vogt et al., 2014)

Dop1R1^f02676 is partially rescued by Scer\GAL4^104Y/Dop1R1^f02676

(Liu et al., 2012)

Dop1R1^f02676 is partially rescued by Scer\GAL4^c205/Dop1R1^f02676

(Liu et al., 2012)

Dop1R1^f02676 is partially rescued by Scer\GAL4^elav-C155/Dop1R1^f02676

(Kim et al., 2007)

In(3LR)234/Dop1R1^f02676 is partially rescued by Scer\GAL4^elav-C155/Dop1R1^f02676

(Kim et al., 2007)

Not rescued by

Dop1R1^f02676 is not rescued by Dop1R1^f02676/Scer\GAL4^VT044966

(Shyu et al., 2017)

Dop1R1^f02676 is not rescued by Dop1R1^f02676/Scer\GAL4^c739

(Shyu et al., 2017)

Dop1R1^f02676 is not rescued by Dop1R1^UAS.cLa/Scer\GAL4^c305a

(Lin et al., 2014)

Dop1R1^f02676 is not rescued by Dop1R1^UAS.cLa/Scer\GAL4^c739

(Lin et al., 2014)

Dop1R1^f02676 is not rescued by Scer\GAL4^c547/Dop1R1^f02676

(Liu et al., 2012)

Dop1R1^f02676 is not rescued by Scer\GAL4^Alp4-c232/Dop1R1^UAS.cKa

(Kong et al., 2010)

Dop1R1^f02676 is not rescued by Dop1R1^UAS.cKa/Scer\GAL4^17d

(Kong et al., 2010)

Dop1R1^f02676 is not rescued by Scer\GAL4^Tab2-201Y/Dop1R1^UAS.cKa

(Kong et al., 2010)

Rescues

Dop1R1^f02676/Scer\GAL4^VT057244 rescues Dop1R1^f02676

(Shyu et al., 2017)

Dop1R1^f02676/Scer\GAL4^Gr5a.8.5 rescues Dop1R1^f02676

(Inagaki et al., 2012)

Scer\GAL4^Mef2.247/Dop1R1^f02676 rescues Dop1R1^f02676

(Liu et al., 2012)

Scer\GAL4^Mef2.247/Dop1R1^f02676 rescues Dop1R1^f02676

(Kim et al., 2007)

Scer\GAL4^Mef2.247/Dop1R1^f02676 rescues In(3LR)234/Dop1R1^f02676

(Kim et al., 2007)

Partially rescues

Scer\GAL4^Mef2.247/Dop1R1^f02676 partially rescues Dop1R1^f02676

(Vogt et al., 2014)

Scer\GAL4^104Y/Dop1R1^f02676 partially rescues Dop1R1^f02676

(Liu et al., 2012)

Scer\GAL4^c205/Dop1R1^f02676 partially rescues Dop1R1^f02676

(Liu et al., 2012)

Scer\GAL4^elav-C155/Dop1R1^f02676 partially rescues Dop1R1^f02676

(Kim et al., 2007)

Scer\GAL4^elav-C155/Dop1R1^f02676 partially rescues In(3LR)234/Dop1R1^f02676

(Kim et al., 2007)

Fails to rescue

Dop1R1^f02676/Scer\GAL4^VT044966 fails to rescue Dop1R1^f02676

(Shyu et al., 2017)

Dop1R1^f02676/Scer\GAL4^c739 fails to rescue Dop1R1^f02676

(Shyu et al., 2017)

Scer\GAL4^c547/Dop1R1^f02676 fails to rescue Dop1R1^f02676

(Liu et al., 2012)

Comments

Expression of Dop1R1^Scer\UAS.cLa in mostly the γ (with Scer\GAL4^NP1131 or Scer\GAL4^Tab2-201Y), but not the αβ (Scer\GAL4^c739) or α'β' (Scer\GAL4^c305a) mushroom body neurons, produces a significant restoration of memory performance.

(Lin et al., 2014)

Expressing DopR^f02676 in Gr5a gustatory receptor neurons under the control of Scer\GAL4^Gr5a.8.5 rescues the defects in the sugar-sensitive proboscis extension reflex (PER) seen in DopR^f02676 mutant females.

(Inagaki et al., 2012)

Expression of DopR (from the Scer\UAS sequences in the PBac{WH}DopR^f02676 insertion) under the control of either Scer\GAL4^104Y or Scer\GAL4^c205 significantly restores the the reduced sleep caused by dopamine signaling in DopR^f02676/DopR^f02676 flies fed L-dopa. This effect is not seen if expression is driven either by Scer\GAL4^ey-OK107 or by Scer\GAL4^c547.

(Liu et al., 2012)

Flies of the genotype Scer\GAL4^5.30/+; DopR^f02676/DopR^f02676 show selectively restored expression of DopR. Those flies that had restored expression in patterns that include the R2/R4 class ellipsoid body neurons exhibit rescue of ethanol-induced hyperactivity. Restoring DopR expression in the R3 neurons of the ellipsoid body neurons (through Scer\GAL4^lilli-189Y) results in a modest but statistically significant increase in ethanol-induced hyperactivity. However, expression with Scer\GAL4^Aph-4-c232 has no effect on ethanol induced hyperactivity in DopR^f02676 homozygous mutants.

(Kong et al., 2010)

The failure of DopR^f02676/In(3LR)234 or DopR^f02676/DopR^f02676 adults to learn to avoid specific odors after conditioning by concurrent shock and odor exposure is partially rescued by Scer\GAL4^elav-C155 and completely rescued by Scer\GAL4^Mef2.247. Scer\GAL4^elav-C155 and Scer\GAL4^Mef2.247 also completely rescued learning by sugar-reward conditioning in these flies. (In all cases, rescue was tested in the presence of Scer\GAL80^ts.αTub84B and rescued was seen at 30'C but not at room temperature.)

(Kim et al., 2007)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

605531

w^*; PBac{WH}Dop1R1^f02676

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

DUMB2

(Noyes and Davis, 2023)

Dop1R1^dumb2

(Jia et al., 2021)

Dop1R1^f02676

(Melnattur et al., 2021, Honegger et al., 2020, Landayan et al., 2018)

DopR1^f02676

(Liu et al., 2017)

DopR^dumb2

(Li et al., 2013)

DopR^f02676

(Pu et al., 2018, Ueno et al., 2017, Jiang et al., 2016, Ueno et al., 2013, Liu et al., 2012)

dDA1^dumb2

(Zhao et al., 2019)

dumb2

(Awata et al., 2019, Miyashita et al., 2018)

dumb²

(Mohandasan et al., 2022, Naganos et al., 2022, Kanno et al., 2021, Melnattur et al., 2021, Kondo et al., 2020, Chen et al., 2019, Kottler et al., 2019, Aranda et al., 2017, Kim et al., 2017, Shyu et al., 2017, Cassar et al., 2015, Ichinose et al., 2015, Shih et al., 2015, Lin et al., 2014, Vogt et al., 2014, Kottler et al., 2013, Liu et al., 2012, Selcho et al., 2009, Kim et al., 2007)

f02676

(Jia et al., 2016, Kottler et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (42)

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