FlyBase Allele Report: Dmel\Atpα[H64]

General Information

Symbol

Dmel\Atpα^H64

Species

D. melanogaster

Name

FlyBase ID

FBal0188144

Feature type

allele

Associated gene

Dmel\Atpα

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl nitrosourea

Nature of the Allele

Allele class

Mutagen

ethyl nitrosourea

(Palladino et al., 2003)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage | dominant

(Palladino et al., 2003)

bang sensitive | dominant

(Palladino et al., 2003)

lethal | embryonic stage

(Palladino et al., 2003)

lethal | recessive

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα^01453a)

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα²²⁰⁶)

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα^DTS1)

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα^DTS1R1)

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα^DTS1R2)

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα^DTS2)

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα^DTS2R1)

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα^DTS2R2)

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα^DTS2R3)

(Palladino et al., 2003)

paralytic | dominant

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^01453a)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα²²⁰⁶)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^DTS1)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^DTS1R1)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^DTS1R2)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^DTS2)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^DTS2R1)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^DTS2R2)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^DTS2R3)

(Palladino et al., 2003)

Phenotype Manifest In

Detailed Description

Statement

Reference

Atpα^H64/+ flies become completely paralyzed for 10-35 seconds following subjection to a mechanical shock. Full recovery from paralysis takes up to 5 minutes. These mutants are sluggish compared to wild-type flies but do not become paralyzed in response to elevated temperatures of 37-38^oC. In the brains of middle-aged Atpα^H64/+ flies, neurodegeneration is evident as the appearance of vacuolar structures. Such structures are rarely seen in wild-type flies.

(Palladino et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions