FlyBase Allele Report: Dmel\Atpα[DTS2R3]

General Information

Symbol

Dmel\Atpα^DTS2R3

Species

D. melanogaster

Name

FlyBase ID

FBal0188146

Feature type

allele

Associated gene

Dmel\Atpα

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - molecular evidence

loss of function allele

Mutagen

gamma ray

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Ashmore et al., 2009)

loss of function allele

(Palladino et al., 2003)

Mutagen

gamma ray

(Palladino et al., 2003)

Progenitor genotype

Atpα^DTS2

(Palladino et al., 2003)

Cytology

Description

Atpα protein expression levels are reduced in heterozygotes.

(Ashmore et al., 2009)

Amino acid replacement: E39A. Amino acid replacement: L346F.

(Palladino et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:20,963,852..20,963,852 [+]

Nucleotide change:

A20963852C

Amino acid change:

Reported amino acid change:

E39A

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change; one of two amino acid substitutions in mutant.

(Palladino et al., 2003)

point_mutation

3R:20,964,906..20,964,906 [+]

Nucleotide change:

C20964906T

Amino acid change:

Reported amino acid change:

L346F

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change; one of two amino acid substitutions in mutant.

(Palladino et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

bang sensitive

(Palladino et al., 2003)

bang sensitive (with Atpα^CJ7)

(Ashmore et al., 2009)

bang sensitive | dominant

(Ashmore et al., 2009)

lethal

(Ashmore et al., 2009)

lethal (with Atpα^CJ4)

(Ashmore et al., 2009)

lethal (with Atpα^CJ5)

(Ashmore et al., 2009)

lethal (with Atpα^CJ6)

(Ashmore et al., 2009)

lethal (with Atpα^CJ10)

(Ashmore et al., 2009)

lethal (with Atpα^CJ12)

(Ashmore et al., 2009)

lethal (with Atpα^CJ13)

(Ashmore et al., 2009)

lethal (with Atpα^DTS1R1)

(Ashmore et al., 2009)

lethal - all die during embryonic stage

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα^01453a)

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα²²⁰⁶)

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα^DTS1)

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα^DTS1R1)

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα^DTS1R2)

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα^DTS2)

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα^DTS2R1)

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα^DTS2R2)

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα^H64)

(Palladino et al., 2003)

paralytic

(Palladino et al., 2003)

some die during embryonic stage

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^01453a)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα²²⁰⁶)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^DTS1)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^DTS1R1)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^DTS1R2)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^DTS2)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^DTS2R1)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^DTS2R2)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^H64)

(Palladino et al., 2003)

Phenotype Manifest In

Detailed Description

Statement

Reference

Heterozygotes are bang sensitive, homozygotes are lethal.

Heterozygous mutants have a significantly lower respiration (metabolic) rate than controls.

(Ashmore et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Atpα^DTS1

(Palladino et al., 2003)

Atpα^DTS2

(Palladino et al., 2003)

Atpα^DTS2R1

(Palladino et al., 2003)

Atpα^DTS2R2

(Palladino et al., 2003)

Atpα^H64

(Palladino et al., 2003)

Atpα^DTS1R1

(Palladino et al., 2003)

Atpα^DTS1R2

(Palladino et al., 2003)

Atpα^01453a

(Palladino et al., 2003)

Atpα²²⁰⁶

(Palladino et al., 2003)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Revertant.

(Palladino et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

ATPalpha^CJ4

(Ashmore et al., 2009)

Atpα^DTS2R3

DTS2^R3

(Palladino et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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