Atf-2c06407 mutant flies are more resistant to Ecc15 infection than wild-type flies and exhibit lower levels of reactive oxygen species in the intestine following infection. Atf-2c06407 mutant flies accumulate lipids in the R2b and R5 regions of the midgut.
Atf-2c06407 heterozygotes and homozygotes relieve w silencing in the In(1)wm4 line in a dose-dependent manner.
Animals that are either maternally or zygotically mutant for Atf-2c06407 show derepression of w in In(1)wm4, and the loss of both maternal and zygotic Atf-2 has an additive effect.
In contrast to controls, Atf-2c06407 mutant flies do not show relieved w silencing in the In(1)wm4 line when embryos are exposed to heat-shock 0-3 hours after egg laying.