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General Information
Symbol
Dmel\Atf-2c06407
Species
D. melanogaster
Name
FlyBase ID
FBal0188163
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of PBac{PB} 69 bp upstream of the Atf-2 translation initiation codon.

Insertion components
PBac{PB}Atf-2c06407
Product class / Tool use(s)
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Atf-2c06407 mutant flies are more resistant to Ecc15 infection than wild-type flies and exhibit lower levels of reactive oxygen species in the intestine following infection. Atf-2c06407 mutant flies accumulate lipids in the R2b and R5 regions of the midgut.

Atf-2c06407 heterozygotes and homozygotes relieve w silencing in the In(1)wm4 line in a dose-dependent manner.

Animals that are either maternally or zygotically mutant for Atf-2c06407 show derepression of w in In(1)wm4, and the loss of both maternal and zygotic Atf-2 has an additive effect.

In contrast to controls, Atf-2c06407 mutant flies do not show relieved w silencing in the In(1)wm4 line when embryos are exposed to heat-shock 0-3 hours after egg laying.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Atf-2c06407 has suppressor of variegation phenotype, enhanceable by spn-E1/spn-E[+]

Atf-2c06407 has suppressor of variegation phenotype, enhanceable by aub[+]/aubQC42

Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

When Atf-2c06407/+ is combined with spn-E1/+ or aubQC42/+, an additive effect on the derepression of w in In(1)wm4 flies is observed.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (4)