FB2025_01 , released February 20, 2025
Allele: Dmel\5-HT2Ae01363
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General Information
Symbol
Dmel\5-HT2Ae01363
Species
D. melanogaster
Name
FlyBase ID
FBal0188344
Feature type
allele
Associated gene
Dmel\5-HT2A
Associated Insertion(s)
PBac{RB}5-HT2Ae01363
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Yuan et al., 2006)
Mutagen
piggyBac activity
(Gene Disruption Project members and Exelixis, 2005)
Progenitor genotype
Associated Insertion(s)
PBac{RB}5-HT2Ae01363
Cytology
Description

PBac{RB}5-HT2e01363 is inserted in the third intron of 5-HT2, disrupting expression of three exons downstream of the insertion, which encode essential intracellular and transmembrane domains.

(Yuan et al., 2006)
Allele components
Component
Use(s)
Inserted element
PBac{RB}
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Similar to wild type, 5-HT2Ae01363 larvae are sensitive to 100μM metitepine and show decreased feeding rates when fed with this drug.

      Unlike wild type, 5-HT2Ae01363/5-HT2AGal4 larvae are resistant to 100μM metitepine, and show relatively higher feeding rates when fed with this drug.

      5-HT2Ae01363/5-HT2AGal4 larvae eat less food than controls (in absence of metitepine).

      (Gasque et al., 2013)

      Neither total sleep nor sleep bout length is significantly different in 5-HT2e01363 flies compared to controls.

      (Yuan et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      5-HT2e01363
      5-HT2Ae01363
      (Gasque et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)