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General Information
Symbol
Dmel\Itgbn2
Species
D. melanogaster
Name
FlyBase ID
FBal0188371
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
βν2, betaInt-nu2
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of P{EP}EP2030 has produced a 2494bp deletion which removes the first 8 codons of βInt-ν and approximately 2kb of upstream regulatory sequence.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Itgbn2 mutant embryonic hemocytes show a decreased competence to undertake phagocytosis of apoptotic cells, despite of no changes in proportions of hemocytes or apoptotic cells in those embryos, as compared to controls. These mutants do not show a delay in development to adulthood, as compared to controls.

Significant overgrowth of the neuromuscular junction (NMJ) (increased bouton number per muscle area and increased NMJ length per muscle area) is seen in βInt-ν1/βInt-ν2 third instar larvae.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Phenotype Manifest In
Enhanced by
Statement
Reference
Enhancer of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Itgbn2, drprΔ5 double mutants show a significant delay in development to adulthood, as compared to wild-type controls and either single mutants.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

No transcript visible by in situ to stage 13 or 15 embryos.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (8)