FlyBase Allele Report: Dmel\park[1]

General Information

Symbol

Dmel\park¹

Species

D. melanogaster

Name

FlyBase ID

FBal0189571

Feature type

allele

Associated gene

Dmel\park

Associated Insertion(s)

P{EP}park¹

Carried in Construct

Also Known As

parkin¹

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Cha et al., 2005)

Progenitor genotype

Associated Insertion(s)

P{EP}park¹

Cytology

Description

An insertion in position +988 of the park ORF, in the middle of exon 5.

(Cha et al., 2005)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:21,195,439..21,195,440

(Han et al., 2021, Cha et al., 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Parkinson's disease

CEA with park^Δ21

(Chen et al., 2017, Wu et al., 2013)

CEA

(Ng et al., 2017, Wang et al., 2016, Wu et al., 2014, Kim et al., 2012, Ng et al., 2012, Wang et al., 2007, Park et al., 2006, Cha et al., 2005)

CEA with Uch^KO

(Ham et al., 2021)

model of Parkinson's disease 2

CEA

(Ham et al., 2023, Miozzo et al., 2022, Erhardt et al., 2021, Ham et al., 2021, Ham et al., 2020)

CEC with park^Δ21

(Huang et al., 2022)

CEC

(Moehlman et al., 2023, Doktór et al., 2019, Basil et al., 2017)

CEA with park^Δ21

(Xue et al., 2022, Reynolds-Peterson et al., 2020, Wan et al., 2020, Wu et al., 2019, Valadas et al., 2018, Shiba-Fukushima et al., 2017)

model of Parkinson's disease 6

CEC with park^Δ21

(Liu et al., 2022)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of Parkinson's disease 2

is ameliorated by Fer2^{fTRG00336.sfGFP-TVPTBF}

(Miozzo et al., 2022)

is ameliorated by Hsap\AFDN^UAS.cBa

(Basil et al., 2017)

is ameliorated by Sting^ΔRG5

(Moehlman et al., 2023)

is ameliorated by Cisd^GD15791

(Ham et al., 2023)

is ameliorated by Cisd^KO

(Ham et al., 2023)

is ameliorated by Itpr^GD1676

(Ham et al., 2023)

is ameliorated by AMPKα^TD.UAS

(Ham et al., 2021)

is ameliorated by Fundc1^{UAS.ORF.GW.Tag:HA}

(Ham et al., 2021)

is ameliorated by Uch^C93S

(Ham et al., 2021)

is ameliorated by Uch^KO

(Ham et al., 2021)

is ameliorated by Uch^E8A

(Ham et al., 2021)

is ameliorated by Uch^GD11265

(Ham et al., 2021)

is ameliorated by Uch^KK101723

(Ham et al., 2021)

is ameliorated by Uch^V96M

(Ham et al., 2021)

model of Parkinson's disease

is ameliorated by GstO1^UAS.cKa

(Kim et al., 2012)

is ameliorated by AMPKα^TD.UAS

(Ng et al., 2012)

is ameliorated by Ucp4A^UAS.cWa

(Wu et al., 2014)

is ameliorated by srl^UAS.cTa

(Ng et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 2 )

FlyBase curator comment: "Parkinson's disease 2" is associated with human PARKIN (the ortholog of park).

(Doktór et al., 2019)

FlyBase curator comment: 'Parkinson's disease' subtype 'Parkinson's disease 2' is associated with gene PRKN.

(Basil et al., 2017)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal flight (with park^Δ21)

(Esposito et al., 2013, Vilain et al., 2012, Vos et al., 2012)

abnormal jumping (with park^Δ21)

(Xue et al., 2022)

abnormal locomotor behavior

(Cha et al., 2005)

abnormal locomotor behavior | adult stage

(Ham et al., 2021, Ng et al., 2017, Wu et al., 2014, Koh et al., 2012, Ng et al., 2012)

abnormal locomotor behavior | adult stage (with park^Δ21)

(Chen et al., 2017)

abnormal locomotor behavior | adult stage | progressive

(Wang et al., 2007)

abnormal locomotor behavior | recessive

(Lee et al., 2011)

abnormal locomotor behavior | third instar larval stage

(Brooks et al., 2016)

abnormal locomotor rhythm

(Cha et al., 2005)

abnormal locomotor rhythm | adult stage

(Doktór et al., 2019)

abnormal neuroanatomy

(Kim et al., 2012, Cha et al., 2005)

abnormal neuroanatomy | adult stage | progressive

(Wang et al., 2007)

abnormal sleep | adult stage

(Doktór et al., 2019)

chemical sensitive | adult stage

(Wang et al., 2007)

decreased cell death

(Cha et al., 2005)

decreased cell number | adult stage

(Ham et al., 2023, Ham et al., 2021)

decreased rate of adult locomotory behavior

(Ham et al., 2023, Moehlman et al., 2023)

female semi-sterile

(Sen et al., 2015)

female semi-sterile (with Df(3L)Pc-MK)

(Sen et al., 2015)

female sterile

(Cox and Spradling, 2009)

flightless

(Park et al., 2009)

flightless (with park^Δ21)

(Reynolds-Peterson et al., 2020)

increased cell death | adult stage

(Ham et al., 2023, Ham et al., 2021, Wang et al., 2016, Wu et al., 2014, Koh et al., 2012)

lethal (with park^Δ21), with Scer\GAL4^da.PU, park^SE.UAS

(Shiba-Fukushima et al., 2014)

male sterile

(Wu et al., 2014, Park et al., 2006)

male sterile (with park^Δ21)

(Vilain et al., 2012)

partially lethal - majority die

(Wang et al., 2016)

short lived

(Doktór et al., 2019, Cha et al., 2005)

short lived | recessive

(Lee et al., 2011)

visible

(Ng et al., 2012, Park et al., 2009, Park et al., 2006)

visible (with park^Δ21)

(Shiba-Fukushima et al., 2014, Wu et al., 2013)

visible | adult stage

(Ham et al., 2023, Moehlman et al., 2023, Ham et al., 2021)

visible | adult stage (with park^Δ21)

(Xue et al., 2022, Chen et al., 2017)

Phenotype Manifest In

adult dopaminergic neuron | decreased number

(Ham et al., 2023)

adult dopaminergic PAM neuron | adult stage

(Miozzo et al., 2022, Wang et al., 2007)

adult somatic muscle cell

(Cha et al., 2005)

adult thorax

(Ham et al., 2023, Moehlman et al., 2023, Ham et al., 2021, Wu et al., 2014, Kim et al., 2012, Koh et al., 2012, Park et al., 2009, Park et al., 2006)

adult thorax (with park^Δ21)

(Xue et al., 2022, Chen et al., 2017)

dopaminergic neuron (with park²⁵)

(Klein et al., 2014)

dopaminergic PPL1 neuron

(Kim et al., 2012, Ng et al., 2012)

dopaminergic PPL1 neuron | adult stage | progressive

(Wang et al., 2007)

dopaminergic PPL1 neuron | decreased number

(Ham et al., 2021)

dopaminergic PPM1 neuron | decreased number

(Ham et al., 2021)

dopaminergic PPM2 neuron | decreased number

(Ham et al., 2021)

endoplasmic reticulum | larval stage

(Ham et al., 2023)

flight muscle cell

(Ham et al., 2023)

flight muscle cell | adult stage

(Ham et al., 2021, Ng et al., 2017)

flight muscle cell | adult stage (with park^Δ21)

(Reynolds-Peterson et al., 2020)

follicle cell

(Cox and Spradling, 2009)

indirect flight muscle

(Moehlman et al., 2023)

indirect flight muscle cell

(Wang et al., 2016, Shiba-Fukushima et al., 2014, Kim et al., 2012, Koh et al., 2012, Ng et al., 2012)

indirect flight muscle cell (with park²⁵)

(Klein et al., 2014)

indirect flight muscle cell (with park^Δ21), with Scer\GAL4^da.PU, park^SA.UAS

(Shiba-Fukushima et al., 2014)

insulin secreting cell of pars intercerebralis

(Cha et al., 2005)

larval muscle cell | larval stage

(Ham et al., 2023)

mitochondrial crista

(Wu et al., 2014)

mitochondrial crista | adult stage (with park^Δ21)

(Chen et al., 2017)

mitochondrial crista | third instar larval stage

(Wang et al., 2016)

mitochondrion

(Moehlman et al., 2023, Sen et al., 2015, Shiba-Fukushima et al., 2014, Ng et al., 2012, Cox and Spradling, 2009, Wang et al., 2007)

mitochondrion (with Df(3L)Pc-MK)

(Sen et al., 2015)

mitochondrion (with park²⁵)

(Klein et al., 2014)

mitochondrion (with park^Δ21)

(Esposito et al., 2013, Wu et al., 2013, Vilain et al., 2012, Vos et al., 2012)

mitochondrion (with park^Δ21), with Scer\GAL4^da.PU, park^SA.UAS

(Shiba-Fukushima et al., 2014)

mitochondrion & skeletal muscle of thorax

(Park et al., 2006)

mitochondrion | adult stage

(Ham et al., 2023, Miozzo et al., 2022, Ham et al., 2021, Ng et al., 2017, Koh et al., 2012)

mitochondrion | adult stage (with park^Δ21)

(Reynolds-Peterson et al., 2020, Chen et al., 2017, Meng et al., 2017)

mitochondrion | third instar larval stage

(Wang et al., 2016)

myofibril & skeletal muscle of thorax

(Park et al., 2006)

Nebenkern

(Park et al., 2006)

Nebenkern derivative

(Cox and Spradling, 2009)

nurse cell

(Cox and Spradling, 2009)

ovary

(Sen et al., 2015)

ovary (with Df(3L)Pc-MK)

(Sen et al., 2015)

thorax (with park^Δ21)

(Shiba-Fukushima et al., 2014)

wing

(Ham et al., 2023, Moehlman et al., 2023, Ham et al., 2021, Kim et al., 2012, Ng et al., 2012, Park et al., 2009, Park et al., 2006, Cha et al., 2005)

wing (with park^Δ21)

(Xue et al., 2022, Chen et al., 2017, Shiba-Fukushima et al., 2014, Wu et al., 2013)

wing blade

(Koh et al., 2012)

Detailed Description

Statement

Reference

In park¹ homozygous adults, PAM neurons show rounder mitochondria.

(Miozzo et al., 2022)

park^Δ21/park¹ adults display wing posture defects, collapsed thoraxes and impaired jumping activity.

(Xue et al., 2022)

park¹ adults show decreased climbing ability, indented adult thoraxes, wing posture defects; their flight muscles show increased apoptosis and swollen mitochondria; there is a decrease in the number of DA PMM1/2 and PPL1 neurons in the brain.

(Ham et al., 2021)

park^Δ21/park¹ mutants exhibit muscle cell abnormalities and degeneration (accumulation of ubiquitin modified proteins and disordering of actin filaments) with large and dysmorphic mitochondria (Mito-GFP) when compared to controls. Also these mutants are incapable of flight.

(Reynolds-Peterson et al., 2020)

park¹/park¹ adult flies have an increased duration of total activity and a shorter duration of nighttime sleep, but similar daytime sleep compared to controls. Under constant dark conditions, flies display a longer period of locomotor activity rhythm.

(Doktór et al., 2019)

park¹/park^Δ21 transheterozygous adults display aberrant wing posture, thoracic indentations and climbing ability deficit along with mitochondrial defects (loss of cristae) in indirect flight muscles.

(Chen et al., 2017)

park¹/park^Δ21 transheterozygotes present mitochondria fragmentation, despite of normal cristae morphology, in adult indirect flight muscles, as compared to controls.

(Meng et al., 2017)

park¹/park¹ flies exhibit a significant decrease in climbing ability, and show mitochondrial defects in flight muscle, as compared to controls.

(Ng et al., 2017)

park¹ homozygous mutant third instar larvae display deficit in locomotion: the crawling speed, distance from start to finish as well as the total length travelled over time are all significantly reduced in the mutant larvae compared to controls.

(Brooks et al., 2016)

park¹/park¹ mutant larval muscles contain abnormal large and swollen mitochondria with disrupted cristae organization, adult indirect flight muscles in young (4-day-old) flies undergo apoptosis (assessed by TUNEL assay).

(Wang et al., 2016)

Mitochondria are mislocalized and clustered in park¹/park¹ or park¹/Df(3L)Pc-MK germ cells in the ovary, and females have greatly reduced fertility (decreased egg-laying).

(Sen et al., 2015)

3-5 day old park¹/park²⁵ mutant flies show indirect flight muscle degeneration. One or several of the six muscles has highly degenerated, highly irregular myofibrils with abnormal sarcomere structure in 65% of the animals as compared to controls.

The indirect flight muscles of park¹/park²⁵ mutants display a heterogeneous population of mitochondria with the majority having significantly enlarged sizes and mild or severe disruption of their cristae structure, when compared to control mitochondria. Severely enlarged mitochondria are also seen in dopaminergic neurons.

park¹/park²⁵ mutants show reduced ATP content in the thorax to approximately 40% of controls. Complex 1 activity is not significantly different from controls.

(Klein et al., 2014)

park¹/park¹ mutants do not display any difference in the number of PPL1 neurons, as compared to controls.

(Navarro et al., 2014)

The mitochondria in the flight muscles of park¹ mutant flies are large compared to controls.

The indirect flight muscles of flies expressing park^SA.Scer\UAS under the control of Scer\GAL4^da.PU in a park^Δ21/park¹ mutant background contain abnormally fused mitochondria.

(Shiba-Fukushima et al., 2014)

park¹/park¹ flies have a crushed thorax (significantly increased percentage of thoracic indentations), locomotor defects (significantly slower climbing), male sterility, degeneration (cell death) and disorganization and fewer mitochondrial cristae in indirect flight muscle.

(Wu et al., 2014)

The flight muscles of park¹/park^Δ21 adults have swollen mitochondria.

(Esposito et al., 2013)

The brains of park¹ mutant third instar larvae are similar in size to wild type.

(Goh et al., 2013)

park¹/park^Δ21 flies often have an abnormal wing posture, and mitochondrial aggregation is seen in the muscles.

(Wu et al., 2013)

park¹ mutants show collapsed thorax and downturned wing phenotypes, due to degeneration of the IFMs.

park¹ mutants show an age-dependent degeneration of DA neurons, especially in the protocerebral posterior lateral 1 (PPL1) cluster.

(Kim et al., 2012)

park¹/park¹ flies have a collapsed thorax phenotype, downturned wings, swollen mitochondria and signs of cell death in the indirect flight muscle (and levels of mtDNA and ATP are reduced), and show significant locomotor defects (reduced climbing ability) compared to controls.

(Koh et al., 2012)

park¹ mutant flies exhibit climbing defects, loss of mitochondrial integrity in the indirect flight muscles and loss of dopaminergic neurons in the protocerebral posterior lateral 1 (PPL1) cluster. These phenotypes can all be significantly rescued upon treatment with EGCG. The climbing defects are also rescued with AICAR, a direct pharmacological activator of AMPK. Both the dopaminergic neuron and climbing defects are rescued upon treatment with another selective AMPK activator, metformin. Conversely, flies treated with a commonly used AMPK inhibitor, Compound C, exhibit markedly increased mortality.

(Ng et al., 2012)

The flight defects of park¹/park^Δ21 animals are significantly improved by feeding with vitamin K[[2]] (MK-4 form tested).

The mitochondrial morphology defects of park¹/park^Δ21 larvae are partially rescued by feeding with vitamin K[[2]] (MK-4 form tested).

(Vos et al., 2012)

The locomotive defect and reduced life span phenotypes of park¹ mutants are not mitigated by feeding the mutant flies with linoleic acid and linolenic acid.

(Lee et al., 2011)

The mitochondrial derivatives in elongated spermatids of homozygous males are irregular and swollen. Only one mitochondrial derivative forms in hemizygous males during spermatogenesis.

Hemizygous females are sterile. Stage 5 follicles show severe mitochondrial clustering in nurse cells, and the clustering worsens with age. Clustering of mitochondria is also seen in the somatic follicle cells.

(Cox and Spradling, 2009)

park¹ fly brains show an obvious loss of dopaminergic neurons in the PPL1 cluster. This loss worsens with age. park¹ fly brains also show loss of dopaminergic neurons in the PAM cluster, though other dopaminergic neuronal clusters, including PAL, PPL2, PPM1/2 and PPM3, are unaffected.

park¹ flies show a significant impairment in the ability in their climbing ability at 10 days after eclosion which progressively worsens with age.

park¹ flies are especially susceptible to rotenone-induced toxicity.

The indirect flight muscles of park¹ flies show prominent mitochondrial defects.

(Wang et al., 2007)

Mutant adults often show a collapsed-thorax phenotype immediately after eclosion and they have a defective wing phenotype. Muscle fibres in the adult thorax are disorganised with enlarged mitochondria and apoptotic muscle cells are seen (in contrast to controls). Males are completely sterile due to defective Nebenkern.

(Park et al., 2006)

park¹ mutants exhibit reduced longevity, a drooped wing phenotype, locomotor dysfunction, and muscle degeneration, accompanied by apoptosis. park¹ mutants exhibit a severe loss of dorsomedial dopaminergic neurons, with the remaining dorsomedial dopaminergic neurons exhibiting a shrunken morphology compared to the age-matched control. Feeding L-DOPA to park¹ mutant flies significantly restores the climbing ability (up to approximately 70% of the unfed wild-type control), whereas D-DOPA has no effect.

(Cha et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

park¹ has abnormal neuroanatomy phenotype, enhanceable by GstO2¹

(Kim et al., 2012)

park¹ has abnormal locomotor behavior | adult stage phenotype, enhanceable by Hsap\PRKN^R275W.UAS/Scer\GAL4^Ddc.PL

(Wang et al., 2007)

NOT Enhanced by

Statement

Reference

park¹ has abnormal locomotor behavior | adult stage phenotype, non-enhanceable by Fundc1^NIG.5676R/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, non-enhanceable by Scer\GAL4^ple.PF/Atg1^NIG.10967R

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, non-enhanceable by Scer\GAL4^ple.PF/AMPKα^NIG.3051R

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, non-enhanceable by Fundc1^{UAS.ORF.GW.Tag:HA}/Scer\GAL4^hs.PB

(Ham et al., 2021)

park^Δ21/park¹ has abnormal locomotor behavior | adult stage phenotype, non-enhanceable by STUB1^I/STUB1^I

(Chen et al., 2017)

park^Δ21/park¹ has abnormal locomotor behavior | adult stage phenotype, non-enhanceable by STUB1^II/STUB1^II

(Chen et al., 2017)

park¹ has abnormal locomotor behavior | third instar larval stage phenotype, non-enhanceable by clu^ΔW/clu^ΔW

(Wang et al., 2016)

park^Δ21/park¹ has visible phenotype, non-enhanceable by rictor^UAS.cHa/Scer\GAL4^da.PU

(Wu et al., 2013)

park^Δ21/park¹ has visible phenotype, non-enhanceable by Scer\GAL4^da.PU/trc^S292E.UAS.L

(Wu et al., 2013)

Suppressed by

Statement

Reference

park¹ has visible | adult stage phenotype, suppressible by Cisd^GD15791/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has increased cell death | adult stage phenotype, suppressible by Cisd^GD15791/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has decreased rate of adult locomotory behavior phenotype, suppressible by Cisd^GD15791/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has decreased cell number | adult stage phenotype, suppressible by Cisd^GD15791/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has visible | adult stage phenotype, suppressible by Cisd^KK109403/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has increased cell death | adult stage phenotype, suppressible by Cisd^KK109403/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has decreased rate of adult locomotory behavior phenotype, suppressible by Cisd^KK109403/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has decreased cell number | adult stage phenotype, suppressible by Cisd^KK109403/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has visible | adult stage phenotype, suppressible by Cisd^KO

(Ham et al., 2023)

park¹ has increased cell death | adult stage phenotype, suppressible by Cisd^KO

(Ham et al., 2023)

park¹ has decreased rate of adult locomotory behavior phenotype, suppressible by Cisd^KO

(Ham et al., 2023)

park¹ has decreased cell number | adult stage phenotype, suppressible by Cisd^KO

(Ham et al., 2023)

park¹ has visible | adult stage phenotype, suppressible | partially by Itpr^GD1676/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has decreased rate of adult locomotory behavior phenotype, suppressible | partially by Itpr^GD1676/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has increased cell death | adult stage phenotype, suppressible | partially by Itpr^GD1676/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has decreased cell number | adult stage phenotype, suppressible | partially by Itpr^GD1676/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has visible | adult stage phenotype, suppressible by Sting^ΔRG5/Sting^ΔRG5

(Moehlman et al., 2023)

park¹ has decreased rate of adult locomotory behavior phenotype, suppressible by Sting^ΔRG5/Sting^ΔRG5

(Moehlman et al., 2023)

park¹ has visible | adult stage phenotype, suppressible | partially by Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has abnormal locomotor behavior | adult stage phenotype, suppressible by Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, suppressible by Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has increased cell death | adult stage phenotype, suppressible by Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, suppressible | partially by Uch^C93S

(Ham et al., 2021)

park¹ has increased cell death | adult stage phenotype, suppressible by Uch^C93S

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, suppressible | partially by Uch^E8A

(Ham et al., 2021)

park¹ has abnormal locomotor behavior | adult stage phenotype, suppressible by Uch^C93S

(Ham et al., 2021)

park¹ has increased cell death | adult stage phenotype, suppressible | partially by Uch^V96M

(Ham et al., 2021)

park¹ has increased cell death | adult stage phenotype, suppressible | partially by Fundc1^NIG.5676R/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has abnormal locomotor behavior | adult stage phenotype, suppressible by Fundc1^{UAS.ORF.GW.Tag:HA}/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has abnormal locomotor behavior | adult stage phenotype, suppressible by Scer\GAL4^ple.PF/AMPKα^TD.UAS

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, suppressible by Fundc1^{UAS.ORF.GW.Tag:HA}/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, suppressible by Scer\GAL4^ple.PF/AMPKα^TD.UAS

(Ham et al., 2021)

park¹ has abnormal locomotor behavior | adult stage phenotype, suppressible by Uch^E8A

(Ham et al., 2021)

park¹ has increased cell death | adult stage phenotype, suppressible | partially by Uch^E8A

(Ham et al., 2021)

park¹ has increased cell death | adult stage phenotype, suppressible | partially by Pyk^NIG.7070R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has abnormal locomotor behavior | adult stage phenotype, suppressible by Pyk^NIG.7070R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, suppressible | partially by Pyk^NIG.7070R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has abnormal locomotor behavior | adult stage phenotype, suppressible by Trim9^UAS.cMa/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, suppressible by Trim9^UAS.cMa/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has increased cell death | adult stage phenotype, suppressible | partially by Trim9^UAS.cMa/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has increased cell death | adult stage phenotype, suppressible | partially by Trim9^NIG.31721R/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has increased cell death | adult stage phenotype, suppressible | partially by Pyk^UAS.Tag:HA/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park^Δ21/park¹ has abnormal flight phenotype, suppressible by sfl[+]/sfl⁰³⁸⁴⁴

(Reynolds-Peterson et al., 2020)

park^Δ21/park¹ has visible | adult stage phenotype, suppressible by STUB1^UAS.cCa/Scer\GAL4^Mhc.PU

(Chen et al., 2017)

park¹ has abnormal locomotor behavior | adult stage phenotype, suppressible by Scer\GAL4^how-24B

(Ng et al., 2017)

park¹ has abnormal locomotor behavior | adult stage phenotype, suppressible by Scer\GAL4^Act.PU/Ucp4A^UAS.cWa

(Wu et al., 2014)

park¹ has male sterile phenotype, suppressible by Scer\GAL4^Act.PU/Ucp4A^UAS.cWa

(Wu et al., 2014)

park¹ has increased cell death | adult stage phenotype, suppressible by Scer\GAL4^Act.PU/Ucp4A^UAS.cWa

(Wu et al., 2014)

park¹ has abnormal neuroanatomy phenotype, suppressible by Scer\GAL4^ple.PF/GstO2^A.UAS

(Kim et al., 2012)

park^Δ21/park¹ has abnormal flight phenotype, suppressible | partially by Scer\GAL4^da.G32/heix^UAS.cVa

(Vos et al., 2012)

park¹ has flightless phenotype, suppressible by Df(1)dx81/+

(Park et al., 2009)

park¹ has visible phenotype, suppressible by opa1-like[+]/Opa1^EY09863

(Park et al., 2009)

NOT suppressed by

Statement

Reference

park^Δ21/park¹ has visible | adult stage phenotype, non-suppressible by Tsf1^KK103815/Scer\GAL4^Mhc.PU

(Xue et al., 2022)

park^Δ21/park¹ has abnormal jumping phenotype, non-suppressible by Tsf1^KK103815/Scer\GAL4^Mhc.PU

(Xue et al., 2022)

park^Δ21/park¹ has visible | adult stage phenotype, non-suppressible by Zip99C^UAS.cXa/Scer\GAL4^Mhc.PU

(Xue et al., 2022)

park^Δ21/park¹ has abnormal jumping phenotype, non-suppressible by Zip99C^UAS.cXa/Scer\GAL4^Mhc.PU

(Xue et al., 2022)

park¹ has increased cell death | adult stage phenotype, non-suppressible by Uch^H19Y

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, non-suppressible by Uch^H19Y

(Ham et al., 2021)

park¹ has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Uch^H19Y

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, non-suppressible by Uch^V96M

(Ham et al., 2021)

park¹ has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Uch^V96M

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, non-suppressible by Fundc1^NIG.5676R/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Fundc1^NIG.5676R/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has abnormal locomotor behavior | adult stage phenotype, non-suppressible by AMPKα^TD.UAS/Fundc1^NIG.5676R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, non-suppressible by Fundc1^{UAS.ORF.GW.Tag:HA}/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, non-suppressible by AMPKα^TD.UAS/Fundc1^NIG.5676R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, non-suppressible by Scer\GAL4^ple.PF/Atg1^NIG.10967R

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, non-suppressible by Scer\GAL4^ple.PF/AMPKα^NIG.3051R

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, non-suppressible by Scer\GAL4^ple.PF/AMPKα^NIG.3051R, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, non-suppressible by Scer\GAL4^ple.PF/Atg1^NIG.10967R, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has increased cell death | adult stage phenotype, non-suppressible by AMPKα^TD.UAS/Fundc1^NIG.5676R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, non-suppressible by Fundc1^NIG.5676R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has increased cell death | adult stage phenotype, non-suppressible by Fundc1^NIG.5676R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Fundc1^NIG.5676R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Trim9^NIG.31721R/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Pyk^UAS.Tag:HA/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has increased cell death | adult stage phenotype, non-suppressible by Pyk^NIG.7070R/Fundc1^NIG.5676R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, non-suppressible by Pyk^NIG.7070R/Fundc1^NIG.5676R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, non-suppressible by Pyk^NIG.7070R/Scer\GAL4^hs.PB/AMPKα^NIG.3051R

(Ham et al., 2021)

park¹ has decreased cell number | adult stage phenotype, non-suppressible by Pyk^NIG.7070R/Scer\GAL4^hs.PB/Atg1^NIG.10967R

(Ham et al., 2021)

park^Δ21/park¹ has abnormal locomotor behavior | adult stage phenotype, non-suppressible by STUB1^UAS.cCa/Scer\GAL4^Mhc.PU

(Chen et al., 2017)

park¹ has abnormal locomotor behavior | third instar larval stage phenotype, non-suppressible by clu^UAS.Tag:MYC/Scer\GAL4^Mef2.PR

(Wang et al., 2016)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU, park¹/park[+] has short lived phenotype, non-suppressible by Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU, park¹/park[+] has abnormal neuroanatomy phenotype, non-suppressible by Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU

(Khalil et al., 2015)

park^Δ21/park¹ has abnormal flight phenotype, non-suppressible by mAcon1¹/Acon[+]

(Esposito et al., 2013)

park^Δ21/park¹ has abnormal flight phenotype, non-suppressible by mAcon1^MB09176/Acon[+]

(Esposito et al., 2013)

park^Δ21/park¹ has visible phenotype, non-suppressible by Scer\GAL4^da.PU/trc^S292E.UAS.L

(Wu et al., 2013)

park^Δ21/park¹ has visible phenotype, non-suppressible by rictor^UAS.cHa/Scer\GAL4^da.PU

(Wu et al., 2013)

park¹ has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Sirt1^UAS.cGa/Scer\GAL4^arm.PU

(Koh et al., 2012)

park¹ has increased cell death | adult stage phenotype, non-suppressible by Sirt1^UAS.cGa/Scer\GAL4^arm.PU

(Koh et al., 2012)

park^Δ21/park¹ has male sterile phenotype, non-suppressible by Scer\NDI1^UAS.cVa

(Vilain et al., 2012)

park^Δ21/park¹ has abnormal flight phenotype, non-suppressible by Scer\NDI1^UAS.cVa/Scer\GAL4^da.G32

(Vilain et al., 2012)

park¹ has flightless phenotype, non-suppressible by Drp1²/Drp1[+]

(Park et al., 2009)

park¹ has flightless phenotype, non-suppressible by opa1-like[+]/Opa1^EY09863

(Park et al., 2009)

park¹ has visible phenotype, non-suppressible by Drp1²/Drp1[+]

(Park et al., 2009)

park¹ has visible phenotype, non-suppressible by Pink1^UAS.Tag:HA/Scer\GAL4^hs.PB

(Park et al., 2006)

Enhancer of

Statement

Reference

park¹ is an enhancer of abnormal locomotor behavior | adult stage phenotype of Hsap\PRKN^R275W.UAS

(Wang et al., 2007)

NOT Enhancer of

Statement

Reference

park¹/park¹ is a non-enhancer of abnormal locomotor behavior | third instar larval stage phenotype of clu^ΔW

(Wang et al., 2016)

Suppressor of

Statement

Reference

park¹ is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

park¹/park¹ is a suppressor of abnormal neuroanatomy | dominant | adult stage | progressive phenotype of Atg1^UAS.cSa, Scer\GAL4^GMR.PF, trp^P365

(Huang et al., 2016)

park¹ is a suppressor of abnormal size | third instar larval stage phenotype of l(2)gl¹/l(2)gl⁴

(Goh et al., 2013)

Other

Statement

Reference

Cisd^GD15791, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has decreased rate of adult locomotory behavior phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has visible | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has increased cell death | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has decreased cell number | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has decreased rate of adult locomotory behavior phenotype

(Ham et al., 2023)

Cisd^GD15791, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has visible | adult stage phenotype

(Ham et al., 2023)

Cisd^GD15791, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has increased cell death | adult stage phenotype

(Ham et al., 2023)

Cisd^GD15791, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has decreased cell number | adult stage phenotype

(Ham et al., 2023)

Cisd^GD15791, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has decreased rate of adult locomotory behavior phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has visible | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has increased cell death | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has decreased cell number | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has decreased rate of adult locomotory behavior phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has visible | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has increased cell death | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has decreased cell number | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has decreased rate of adult locomotory behavior phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has visible | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has increased cell death | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has decreased cell number | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has decreased rate of adult locomotory behavior phenotype

(Ham et al., 2023)

Cisd^GD15791, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has visible | adult stage phenotype

(Ham et al., 2023)

Cisd^GD15791, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has increased cell death | adult stage phenotype

(Ham et al., 2023)

Cisd^GD15791, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has decreased cell number | adult stage phenotype

(Ham et al., 2023)

Atg5^JF02703, Scer\GAL4^Mef2.PR, park^Δ21/park¹, sfl^unspecified has partially lethal phenotype

(Reynolds-Peterson et al., 2020)

clu^ΔW, park¹ has lethal phenotype

(Wang et al., 2016)

clu^EP969, park¹/park[+] has female fertile phenotype

(Cox and Spradling, 2009)

clu^EP969, park¹/park[+] has male fertile phenotype

(Cox and Spradling, 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

park¹ has mitochondrion | third instar larval stage phenotype, enhanceable by clu^ΔW/clu^ΔW

(Wang et al., 2016)

park¹ has indirect flight muscle cell phenotype, enhanceable by GstO2¹

(Kim et al., 2012)

park¹ has dopaminergic PPL1 neuron phenotype, enhanceable by GstO2¹

(Kim et al., 2012)

park¹ has wing phenotype, enhanceable by Scer\GAL4^how-24B/ATPsynβ^NIG.11154R

(Kim et al., 2012)

park¹ has adult thorax phenotype, enhanceable by Scer\GAL4^how-24B/ATPsynβ^NIG.11154R

(Kim et al., 2012)

NOT Enhanced by

Statement

Reference

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, non-enhanceable by Fundc1^NIG.5676R/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, non-enhanceable by Fundc1^NIG.5676R/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, non-enhanceable by Scer\GAL4^ple.PF/Atg1^NIG.10967R

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, non-enhanceable by Scer\GAL4^ple.PF/Atg1^NIG.10967R

(Ham et al., 2021)

park¹ has dopaminergic PPL1 neuron | decreased number phenotype, non-enhanceable by Scer\GAL4^ple.PF/Atg1^NIG.10967R

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, non-enhanceable by Scer\GAL4^ple.PF/AMPKα^NIG.3051R

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, non-enhanceable by Scer\GAL4^ple.PF/AMPKα^NIG.3051R

(Ham et al., 2021)

park^Δ21/park¹ has mitochondrion | adult stage phenotype, non-enhanceable by Chchd2^H43/Chchd2^H43

(Meng et al., 2017)

park^Δ21/park¹ has mitochondrion phenotype, non-enhanceable by rictor^UAS.cHa/Scer\GAL4^da.PU

(Wu et al., 2013)

park^Δ21/park¹ has wing phenotype, non-enhanceable by Scer\GAL4^da.PU/trc^S292E.UAS.L

(Wu et al., 2013)

park^Δ21/park¹ has mitochondrion phenotype, non-enhanceable by Scer\GAL4^da.PU/trc^S292E.UAS.L

(Wu et al., 2013)

park^Δ21/park¹ has wing phenotype, non-enhanceable by rictor^UAS.cHa/Scer\GAL4^da.PU

(Wu et al., 2013)

park¹ has dopaminergic PPL1 neuron | adult stage phenotype, non-enhanceable by Hsap\PRKN^R275W.UAS/Scer\GAL4^Ddc.PL

(Wang et al., 2007)

park¹ has adult dopaminergic PAM neuron | adult stage phenotype, non-enhanceable by Hsap\PRKN^R275W.UAS/Scer\GAL4^Ddc.PL

(Wang et al., 2007)

Suppressed by

Statement

Reference

park¹ has endoplasmic reticulum | larval stage phenotype, suppressible by Scer\GAL4^Mef2.PR/Cisd^GD15791

(Ham et al., 2023)

park¹ has endoplasmic reticulum | larval stage phenotype, suppressible by Cisd^KK109403/Scer\GAL4^Mef2.PR

(Ham et al., 2023)

park¹ has endoplasmic reticulum | larval stage phenotype, suppressible by Cisd^KO

(Ham et al., 2023)

park¹ has adult thorax phenotype, suppressible by Cisd^GD15791/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has wing phenotype, suppressible by Cisd^GD15791/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has mitochondrion | adult stage phenotype, suppressible by Cisd^GD15791/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has flight muscle cell phenotype, suppressible by Cisd^GD15791/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has adult dopaminergic neuron | decreased number phenotype, suppressible by Cisd^GD15791/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has adult thorax phenotype, suppressible by Cisd^KK109403/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has wing phenotype, suppressible by Cisd^KK109403/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has mitochondrion | adult stage phenotype, suppressible by Cisd^KK109403/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has flight muscle cell phenotype, suppressible by Cisd^KK109403/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has adult dopaminergic neuron | decreased number phenotype, suppressible by Cisd^KK109403/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has adult thorax phenotype, suppressible by Cisd^KO

(Ham et al., 2023)

park¹ has wing phenotype, suppressible by Cisd^KO

(Ham et al., 2023)

park¹ has mitochondrion | adult stage phenotype, suppressible by Cisd^KO

(Ham et al., 2023)

park¹ has flight muscle cell phenotype, suppressible by Cisd^KO

(Ham et al., 2023)

park¹ has adult dopaminergic neuron | decreased number phenotype, suppressible by Cisd^KO

(Ham et al., 2023)

park¹ has adult thorax phenotype, suppressible | partially by Itpr^GD1676/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has wing phenotype, suppressible | partially by Itpr^GD1676/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has mitochondrion | adult stage phenotype, suppressible | partially by Itpr^GD1676/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has flight muscle cell phenotype, suppressible | partially by Itpr^GD1676/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has adult dopaminergic neuron | decreased number phenotype, suppressible | partially by Itpr^GD1676/Scer\GAL4^hs.PB

(Ham et al., 2023)

park¹ has larval muscle cell | larval stage phenotype, suppressible by Scer\GAL4^Mef2.PR/Cisd^GD15791

(Ham et al., 2023)

park¹ has larval muscle cell | larval stage phenotype, suppressible by Cisd^KK109403/Scer\GAL4^Mef2.PR

(Ham et al., 2023)

park¹ has larval muscle cell | larval stage phenotype, suppressible by Cisd^KO

(Ham et al., 2023)

park¹ has adult thorax phenotype, suppressible by Sting^ΔRG5/Sting^ΔRG5

(Moehlman et al., 2023)

park¹ has indirect flight muscle phenotype, suppressible by Sting^ΔRG5/Sting^ΔRG5

(Moehlman et al., 2023)

park¹ has wing phenotype, suppressible by Sting^ΔRG5/Sting^ΔRG5

(Moehlman et al., 2023)

park¹ has mitochondrion phenotype, suppressible | partially by Sting^ΔRG5/Sting^ΔRG5

(Moehlman et al., 2023)

park¹ has adult thorax phenotype, suppressible | partially by cGlr2^KO/cGlr2^KO/cGlr1^KO/cGlr1^KO

(Moehlman et al., 2023)

park¹ has mitochondrion | adult stage phenotype, suppressible by Fer2^{fTRG00336.sfGFP-TVPTBF}

(Miozzo et al., 2022)

park¹ has adult dopaminergic PAM neuron | adult stage phenotype, suppressible by Fer2^{fTRG00336.sfGFP-TVPTBF}

(Miozzo et al., 2022)

park¹ has adult thorax phenotype, suppressible by Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has wing phenotype, suppressible | partially by Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has mitochondrion | adult stage phenotype, suppressible by Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has flight muscle cell | adult stage phenotype, suppressible by Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, suppressible by Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, suppressible by Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has mitochondrion | adult stage phenotype, suppressible | partially by Uch^V96M

(Ham et al., 2021)

park¹ has flight muscle cell | adult stage phenotype, suppressible | partially by Uch^V96M

(Ham et al., 2021)

park¹ has flight muscle cell | adult stage phenotype, suppressible | partially by Fundc1^NIG.5676R/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has mitochondrion | adult stage phenotype, suppressible | partially by Fundc1^NIG.5676R/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, suppressible by Scer\GAL4^ple.PF/AMPKα^TD.UAS

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, suppressible by Scer\GAL4^ple.PF/AMPKα^TD.UAS

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, suppressible by Fundc1^{UAS.ORF.GW.Tag:HA}/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, suppressible by Fundc1^{UAS.ORF.GW.Tag:HA}/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has flight muscle cell | adult stage phenotype, suppressible | partially by Uch^E8A

(Ham et al., 2021)

park¹ has mitochondrion | adult stage phenotype, suppressible | partially by Uch^E8A

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, suppressible | partially by Uch^E8A

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, suppressible | partially by Uch^E8A

(Ham et al., 2021)

park¹ has flight muscle cell | adult stage phenotype, suppressible by Uch^C93S

(Ham et al., 2021)

park¹ has mitochondrion | adult stage phenotype, suppressible by Uch^C93S

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, suppressible by Uch^C93S

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, suppressible by Uch^C93S

(Ham et al., 2021)

park¹ has dopaminergic PPL1 neuron | decreased number phenotype, suppressible by Uch^E8A

(Ham et al., 2021)

park¹ has dopaminergic PPL1 neuron | decreased number phenotype, suppressible by Uch^C93S

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, suppressible by Pyk^NIG.7070R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, suppressible by Pyk^NIG.7070R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has dopaminergic PPL1 neuron | decreased number phenotype, suppressible by Pyk^NIG.7070R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, suppressible by Trim9^UAS.cMa/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, suppressible by Trim9^UAS.cMa/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has flight muscle cell | adult stage phenotype, suppressible | partially by Pyk^NIG.7070R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has mitochondrion | adult stage phenotype, suppressible | partially by Pyk^NIG.7070R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has mitochondrion | adult stage phenotype, suppressible | partially by Trim9^UAS.cMa/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has flight muscle cell | adult stage phenotype, suppressible | partially by Trim9^UAS.cMa/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has dopaminergic PPL1 neuron | decreased number phenotype, suppressible by Trim9^UAS.cMa/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has flight muscle cell | adult stage phenotype, suppressible | partially by Trim9^NIG.31721R/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has mitochondrion | adult stage phenotype, suppressible | partially by Trim9^NIG.31721R/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has flight muscle cell | adult stage phenotype, suppressible | partially by Pyk^UAS.Tag:HA/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has mitochondrion | adult stage phenotype, suppressible | partially by Pyk^UAS.Tag:HA/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has mitochondrion | adult stage phenotype, suppressible by Uch^GD11265/Scer\GAL4^Mef2.PR

(Ham et al., 2021)

park¹ has mitochondrion | adult stage phenotype, suppressible by Uch^H19Y/Scer\GAL4^Mef2.PR

(Ham et al., 2021)

park¹ has flight muscle cell | adult stage phenotype, suppressible by Uch^GD11265/Scer\GAL4^Mef2.PR

(Ham et al., 2021)

park¹ has flight muscle cell | adult stage phenotype, suppressible by Uch^H19Y/Scer\GAL4^Mef2.PR

(Ham et al., 2021)

park^Δ21/park¹ has flight muscle cell | adult stage phenotype, suppressible by sfl[+]/sfl⁰³⁸⁴⁴

(Reynolds-Peterson et al., 2020)

park^Δ21/park¹ has flight muscle cell | adult stage phenotype, suppressible by sfl^9B4

(Reynolds-Peterson et al., 2020)

park^Δ21/park¹ has flight muscle cell | adult stage phenotype, suppressible by sfl[+]/sfl^unspecified

(Reynolds-Peterson et al., 2020)

park^Δ21/park¹ has mitochondrion | adult stage phenotype, suppressible by sfl[+]/sfl^unspecified

(Reynolds-Peterson et al., 2020)

park^Δ21/park¹ has wing phenotype, suppressible by STUB1^UAS.cCa/Scer\GAL4^Mhc.PU

(Chen et al., 2017)

park^Δ21/park¹ has adult thorax phenotype, suppressible by STUB1^UAS.cCa/Scer\GAL4^Mhc.PU

(Chen et al., 2017)

park^Δ21/park¹ has mitochondrion | adult stage phenotype, suppressible by STUB1^UAS.cCa/Scer\GAL4^Mhc.PU

(Chen et al., 2017)

park^Δ21/park¹ has mitochondrial crista | adult stage phenotype, suppressible by STUB1^UAS.cCa/Scer\GAL4^Mhc.PU

(Chen et al., 2017)

park¹ has mitochondrion | adult stage phenotype, suppressible by Scer\GAL4^how-24B

(Ng et al., 2017)

park¹ has flight muscle cell | adult stage phenotype, suppressible by Scer\GAL4^how-24B

(Ng et al., 2017)

park¹ has adult thorax phenotype, suppressible by Scer\GAL4^Act.PU/Ucp4A^UAS.cWa

(Wu et al., 2014)

park¹ has mitochondrial crista phenotype, suppressible by Scer\GAL4^Act.PU/Ucp4A^UAS.cWa

(Wu et al., 2014)

park¹ has wing phenotype, suppressible by Scer\GAL4^how-24B/GstO2^A.UAS

(Kim et al., 2012)

park¹ has adult thorax phenotype, suppressible by Scer\GAL4^how-24B/GstO2^A.UAS

(Kim et al., 2012)

park¹ has indirect flight muscle cell phenotype, suppressible by GstO2^A.UAS/Scer\GAL4^αTub84B.PL

(Kim et al., 2012)

park¹ has dopaminergic PPL1 neuron phenotype, suppressible by Scer\GAL4^ple.PF/GstO2^A.UAS

(Kim et al., 2012)

park¹ has wing phenotype, suppressible by Drp1^UAS.Tag:HA/Scer\GAL4^hs.PB

(Park et al., 2009)

park¹ has adult thorax phenotype, suppressible by Drp1^UAS.Tag:HA/Scer\GAL4^hs.PB

(Park et al., 2009)

park¹ has wing phenotype, suppressible by Df(1)dx81/+

(Park et al., 2009)

park¹ has adult thorax phenotype, suppressible by Df(1)dx81/+

(Park et al., 2009)

park¹ has wing phenotype, suppressible by opa1-like[+]/Opa1^EY09863

(Park et al., 2009)

park¹ has adult thorax phenotype, suppressible by opa1-like[+]/Opa1^EY09863

(Park et al., 2009)

Pink1^B9, park¹ has mitochondrion phenotype, suppressible by park^{UAS.Tag:FLAG,Tag:Mito(hCOX4I1)}/Scer\GAL4^hs.PB

(Kim et al., 2008)

Pink1^B9, park¹ has mitochondrion phenotype, suppressible | partially by park^UAS.Tag:MYC/Scer\GAL4^hs.PB

(Kim et al., 2008)

Pink1^B9, park¹ has mitochondrion phenotype, suppressible | partially by park^{T187A.UAS.Tag:MYC}/Scer\GAL4^hs.PB

(Kim et al., 2008)

park¹ has dopaminergic PPL1 neuron | adult stage phenotype, suppressible by Hsap\PRKN^WT.UAS/Scer\GAL4^Ddc.PL

(Wang et al., 2007)

park¹ has adult dopaminergic PAM neuron | adult stage phenotype, suppressible by Hsap\PRKN^WT.UAS/Scer\GAL4^Ddc.PL

(Wang et al., 2007)

park¹ has mitochondrion phenotype, suppressible by Hsap\PRKN^WT.UAS/Scer\GAL4^how-24B

(Wang et al., 2007)

NOT suppressed by

Statement

Reference

park¹ has wing phenotype, non-suppressible by cGlr2^KO/cGlr2^KO/cGlr1^KO/cGlr1^KO

(Moehlman et al., 2023)

park^Δ21/park¹ has adult thorax phenotype, non-suppressible by Tsf1^KK103815/Scer\GAL4^Mhc.PU

(Xue et al., 2022)

park^Δ21/park¹ has wing phenotype, non-suppressible by Zip99C^UAS.cXa/Scer\GAL4^Mhc.PU

(Xue et al., 2022)

park^Δ21/park¹ has adult thorax phenotype, non-suppressible by Zip99C^UAS.cXa/Scer\GAL4^Mhc.PU

(Xue et al., 2022)

park^Δ21/park¹ has wing phenotype, non-suppressible by Tsf1^KK103815/Scer\GAL4^Mhc.PU

(Xue et al., 2022)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, non-suppressible by Uch^V96M

(Ham et al., 2021)

park¹ has mitochondrion | adult stage phenotype, non-suppressible by Uch^H19Y

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, non-suppressible by Uch^V96M

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, non-suppressible by Uch^H19Y

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, non-suppressible by Uch^H19Y

(Ham et al., 2021)

park¹ has flight muscle cell | adult stage phenotype, non-suppressible by Uch^H19Y

(Ham et al., 2021)

park¹ has dopaminergic PPL1 neuron | decreased number phenotype, non-suppressible by Fundc1^NIG.5676R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has dopaminergic PPL1 neuron | decreased number phenotype, non-suppressible by Fundc1^NIG.5676R/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, non-suppressible by Fundc1^NIG.5676R/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, non-suppressible by Fundc1^NIG.5676R/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, non-suppressible by Scer\GAL4^ple.PF/Atg1^NIG.10967R

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, non-suppressible by Scer\GAL4^ple.PF/Atg1^NIG.10967R

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, non-suppressible by Scer\GAL4^ple.PF/AMPKα^NIG.3051R

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, non-suppressible by Scer\GAL4^ple.PF/AMPKα^NIG.3051R

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, non-suppressible by Scer\GAL4^ple.PF/AMPKα^NIG.3051R, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, non-suppressible by Scer\GAL4^ple.PF/AMPKα^NIG.3051R, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, non-suppressible by Scer\GAL4^ple.PF/AMPKα^TD.UAS

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, non-suppressible by Scer\GAL4^ple.PF/AMPKα^TD.UAS

(Ham et al., 2021)

park¹ has dopaminergic PPL1 neuron | decreased number phenotype, non-suppressible by Uch^V96M

(Ham et al., 2021)

park¹ has dopaminergic PPL1 neuron | decreased number phenotype, non-suppressible by Uch^H19Y

(Ham et al., 2021)

park¹ has dopaminergic PPL1 neuron | decreased number phenotype, non-suppressible by Scer\GAL4^ple.PF/AMPKα^NIG.3051R, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has dopaminergic PPL1 neuron | decreased number phenotype, non-suppressible by Scer\GAL4^ple.PF/AMPKα^TD.UAS

(Ham et al., 2021)

park¹ has dopaminergic PPL1 neuron | decreased number phenotype, non-suppressible by Scer\GAL4^ple.PF/Atg1^NIG.10967R

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, non-suppressible by Scer\GAL4^ple.PF/Atg1^NIG.10967R, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, non-suppressible by Scer\GAL4^ple.PF/Atg1^NIG.10967R, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has dopaminergic PPL1 neuron | decreased number phenotype, non-suppressible by Scer\GAL4^ple.PF/Atg1^NIG.10967R, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, non-suppressible by AMPKα^TD.UAS/Fundc1^NIG.5676R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, non-suppressible by AMPKα^TD.UAS/Fundc1^NIG.5676R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has mitochondrion | adult stage phenotype, non-suppressible by AMPKα^TD.UAS/Fundc1^NIG.5676R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has flight muscle cell | adult stage phenotype, non-suppressible by AMPKα^TD.UAS/Fundc1^NIG.5676R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, non-suppressible by Fundc1^NIG.5676R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, non-suppressible by Fundc1^NIG.5676R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has flight muscle cell | adult stage phenotype, non-suppressible by Fundc1^NIG.5676R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has mitochondrion | adult stage phenotype, non-suppressible by Fundc1^NIG.5676R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has dopaminergic PPL1 neuron | decreased number phenotype, non-suppressible by Trim9^NIG.31721R/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, non-suppressible by Pyk^UAS.Tag:HA/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, non-suppressible by Pyk^UAS.Tag:HA/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has dopaminergic PPL1 neuron | decreased number phenotype, non-suppressible by Pyk^UAS.Tag:HA/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, non-suppressible by Trim9^NIG.31721R/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, non-suppressible by Trim9^NIG.31721R/Scer\GAL4^hs.PB, Uch^KO/Uch^KO

(Ham et al., 2021)

park¹ has mitochondrion | adult stage phenotype, non-suppressible by Pyk^NIG.7070R/Fundc1^NIG.5676R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, non-suppressible by Pyk^NIG.7070R/Fundc1^NIG.5676R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, non-suppressible by Pyk^NIG.7070R/Fundc1^NIG.5676R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has flight muscle cell | adult stage phenotype, non-suppressible by Pyk^NIG.7070R/Fundc1^NIG.5676R/Scer\GAL4^hs.PB

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, non-suppressible by Pyk^NIG.7070R/Scer\GAL4^hs.PB/AMPKα^NIG.3051R

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, non-suppressible by Pyk^NIG.7070R/Scer\GAL4^hs.PB/AMPKα^NIG.3051R

(Ham et al., 2021)

park¹ has dopaminergic PPL1 neuron | decreased number phenotype, non-suppressible by Pyk^NIG.7070R/Scer\GAL4^hs.PB/AMPKα^NIG.3051R

(Ham et al., 2021)

park¹ has dopaminergic PPM2 neuron | decreased number phenotype, non-suppressible by Pyk^NIG.7070R/Scer\GAL4^hs.PB/Atg1^NIG.10967R

(Ham et al., 2021)

park¹ has dopaminergic PPL1 neuron | decreased number phenotype, non-suppressible by Pyk^NIG.7070R/Scer\GAL4^hs.PB/Atg1^NIG.10967R

(Ham et al., 2021)

park¹ has dopaminergic PPM1 neuron | decreased number phenotype, non-suppressible by Pyk^NIG.7070R/Scer\GAL4^hs.PB/Atg1^NIG.10967R

(Ham et al., 2021)

park¹ has mitochondrion | adult stage phenotype, non-suppressible by Pyk^NIG.7070R/Scer\GAL4^hs.PB/Atg1^NIG.10967R

(Ham et al., 2021)

park¹ has flight muscle cell | adult stage phenotype, non-suppressible by Pyk^NIG.7070R/Scer\GAL4^hs.PB/Atg1^NIG.10967R

(Ham et al., 2021)

park¹ has mitochondrion | third instar larval stage phenotype, non-suppressible by clu^UAS.Tag:MYC/Scer\GAL4^Mef2.PR

(Wang et al., 2016)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU, park¹/park[+] has eye photoreceptor cell phenotype, non-suppressible by Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU

(Khalil et al., 2015)

park¹/park²⁵ has indirect flight muscle cell phenotype, non-suppressible by Ret^MEN2B.UAS/Scer\GAL4^Mef2.PR

(Klein et al., 2014)

park¹/park²⁵ has indirect flight muscle cell phenotype, non-suppressible by Scer\GAL4^Mhc.PK/Ret^MEN2B.UAS/Scer\GAL80^ts.αTub84B

(Klein et al., 2014)

park¹/park²⁵ has mitochondrion phenotype, non-suppressible by Ret^MEN2B.UAS/Scer\GAL4^Mef2.PR

(Klein et al., 2014)

park¹/park²⁵ has dopaminergic neuron phenotype, non-suppressible by Ret^MEN2B.UAS/Scer\GAL4^Mef2.PR

(Klein et al., 2014)

park^Δ21/park¹ has wing phenotype, non-suppressible by rictor^UAS.cHa/Scer\GAL4^da.PU

(Wu et al., 2013)

park^Δ21/park¹ has mitochondrion phenotype, non-suppressible by rictor^UAS.cHa/Scer\GAL4^da.PU

(Wu et al., 2013)

park^Δ21/park¹ has wing phenotype, non-suppressible by Scer\GAL4^da.PU/trc^S292E.UAS.L

(Wu et al., 2013)

park^Δ21/park¹ has mitochondrion phenotype, non-suppressible by Scer\GAL4^da.PU/trc^S292E.UAS.L

(Wu et al., 2013)

park¹ has wing phenotype, non-suppressible by Scer\GAL4^how-24B/GstO2^B.UAS

(Kim et al., 2012)

park¹ has adult thorax phenotype, non-suppressible by Scer\GAL4^how-24B/GstO2^B.UAS

(Kim et al., 2012)

park¹ has wing phenotype, non-suppressible by GstO1^UAS.cKa/Scer\GAL4^how-24B

(Kim et al., 2012)

park¹ has adult thorax phenotype, non-suppressible by GstO1^UAS.cKa/Scer\GAL4^how-24B

(Kim et al., 2012)

park¹ has wing phenotype, non-suppressible by Scer\GAL4^how-24B/GstO2^C31A.A.UAS

(Kim et al., 2012)

park¹ has adult thorax phenotype, non-suppressible by Scer\GAL4^how-24B/GstO2^C31A.A.UAS

(Kim et al., 2012)

park¹ has adult thorax phenotype, non-suppressible by Sirt1^UAS.cGa/Scer\GAL4^arm.PU

(Koh et al., 2012)

park¹ has mitochondrion | adult stage phenotype, non-suppressible by Sirt1^UAS.cGa/Scer\GAL4^arm.PU

(Koh et al., 2012)

park¹ has indirect flight muscle cell phenotype, non-suppressible by Sirt1^UAS.cGa/Scer\GAL4^arm.PU

(Koh et al., 2012)

park¹ has wing blade phenotype, non-suppressible by Sirt1^UAS.cGa/Scer\GAL4^arm.PU

(Koh et al., 2012)

park^Δ21/park¹ has mitochondrion phenotype, non-suppressible by Scer\NDI1^UAS.cVa/Scer\GAL4^da.G32

(Vilain et al., 2012)

park¹ has wing phenotype, non-suppressible by Drp1²/Drp1[+]

(Park et al., 2009)

park¹ has adult thorax phenotype, non-suppressible by Drp1²/Drp1[+]

(Park et al., 2009)

park¹ has dopaminergic PPL1 neuron | adult stage phenotype, non-suppressible by Hsap\PRKN^R275W.UAS/Scer\GAL4^Ddc.PL

(Wang et al., 2007)

park¹ has adult dopaminergic PAM neuron | adult stage phenotype, non-suppressible by Hsap\PRKN^R275W.UAS/Scer\GAL4^Ddc.PL

(Wang et al., 2007)

park¹ has mitochondrion phenotype, non-suppressible by Scer\GAL4^how-24B/Hsap\PRKN^R275W.UAS

(Wang et al., 2007)

park¹ has wing phenotype, non-suppressible by Pink1^UAS.Tag:HA/Scer\GAL4^hs.PB

(Park et al., 2006)

park¹ has adult thorax phenotype, non-suppressible by Pink1^UAS.Tag:HA/Scer\GAL4^hs.PB

(Park et al., 2006)

park¹ has myofibril & skeletal muscle of thorax phenotype, non-suppressible by Pink1^UAS.Tag:HA/Scer\GAL4^hs.PB

(Park et al., 2006)

park¹ has mitochondrion & skeletal muscle of thorax phenotype, non-suppressible by Pink1^UAS.Tag:HA/Scer\GAL4^hs.PB

(Park et al., 2006)

Enhancer of

Statement

Reference

park¹/park¹ is an enhancer of mitochondrion | third instar larval stage phenotype of clu^ΔW

(Wang et al., 2016)

Suppressor of

Statement

Reference

park¹ is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

park¹/park¹ is a suppressor of rhabdomere of eye photoreceptor cell | adult stage | progressive phenotype of Atg1^UAS.cSa, Scer\GAL4^GMR.PF, trp^P365

(Huang et al., 2016)

park¹/park²⁵ is a suppressor | partially of indirect flight muscle cell phenotype of Ret^MEN2B.UAS, Scer\GAL4^Mef2.PR

(Klein et al., 2014)

park¹ is a suppressor of brain | third instar larval stage phenotype of l(2)gl¹/l(2)gl⁴

(Goh et al., 2013)

Other

Statement

Reference

Cisd^GD15791, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has mitochondrion | adult stage phenotype

(Ham et al., 2023)

Cisd^GD15791, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has adult dopaminergic neuron | decreased number phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has wing phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has adult thorax phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has flight muscle cell phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has mitochondrion | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has adult dopaminergic neuron | decreased number phenotype

(Ham et al., 2023)

Cisd^GD15791, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has wing phenotype

(Ham et al., 2023)

Cisd^GD15791, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has adult thorax phenotype

(Ham et al., 2023)

Cisd^GD15791, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has flight muscle cell phenotype

(Ham et al., 2023)

Cisd^GD15791, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has mitochondrion | adult stage phenotype

(Ham et al., 2023)

Cisd^GD15791, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has adult dopaminergic neuron | decreased number phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has adult thorax phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has flight muscle cell phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has mitochondrion | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has adult dopaminergic neuron | decreased number phenotype

(Ham et al., 2023)

Cisd^GD15791, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has wing phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has wing phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has adult thorax phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has flight muscle cell phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has mitochondrion | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has adult dopaminergic neuron | decreased number phenotype

(Ham et al., 2023)

Cisd^GD15791, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has adult thorax phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has wing phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has adult thorax phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has flight muscle cell phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has mitochondrion | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has adult dopaminergic neuron | decreased number phenotype

(Ham et al., 2023)

Cisd^GD15791, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has flight muscle cell phenotype

(Ham et al., 2023)

clu^ΔW, park¹/park[+] has mitochondrion | third instar larval stage phenotype

(Wang et al., 2016)

clu^EP969, park¹/park[+] has mitochondrion phenotype

(Cox and Spradling, 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The aberrant wing posture, thoracic indentations along with mitochondrial defects (loss of cristae) in indirect flight muscles observed in park¹/park^Δ21 transheterozygous adults are all significantly rescued by Scer\GAL4^Mhc.PU-driven expression of STUB1^Scer\UAS.cCa, whereas their climbing ability deficit is not improved.

The reduced climbing ability of park¹/park^Δ21 mutants is not exacerbated by combination with either STUB1^I or STUB1^II in homozygous state, but the lifespan of the double mutants is significantly decreased compared to park¹/park^Δ21 single mutants.

(Chen et al., 2017)

The mitochondria morphology defects observed in the adult indirect flight muscles of park¹/park^Δ21 transheterozygotes are not enhanced by Chchd2^H43 homozygosity.

(Meng et al., 2017)

Expression of srl^Scer\UAS.cTa under the control of Scer\GAL4^how-24B suppresses the climbing defects and mitochondrial defects seen in park¹/park¹ mutants.

(Ng et al., 2017)

park¹/park¹ suppresses the ability of Scer\GAL4^GMR.PF>Atg1^Scer\UAS.cSa to suppress age-dependent retinal degeneration (loss of rhabdomeres from photoreceptors) in trp^P365/+ flies.

(Huang et al., 2016)

Neither the swollen mitochondria phenotype nor the the locomotion deficit characteristic for park¹ homozygous mutant third instar larvae can be suppressed by Scer\GAL4^Mef2.PR-driven expression of clu^UAS.Tag:MYC.

clu^ΔW/+;park¹/+ double heterozygous larvae show abnormal clustering of mitochondria around nuclei in muscle cells that is not observed in either of the single heterozygotes.

The mitochondrial morphology defects observed in larval muscles of both clu^ΔW and park¹ homozygotes are exacerbated further in the double mutants, moreover while either clu^ΔW or park¹ are partially lethal with about 5-10% of adult escapers, clu^ΔW/clu^ΔW;park¹/park¹ mutants do not yield any viable adults. On the other hand the larval locomotor deficit of either of the single mutants is not significantly worsened in the double mutants.

(Wang et al., 2016)

Expression of Ret^{MEN2B.Scer\UAS} under the control of Scer\GAL4^Mef2.PR does not suppress the muscle morphology phenotype seen in the indirect flight muscles of park¹/park²⁵ mutants. The frequency of flies with "actin blobs" is decreased markedly compared to Ret^{MEN2B.Scer\UAS} expressing controls. The structural impairments seen in park¹/park²⁵ mutant mitochondria are not suppressed. The reduction in thoracic ATP levels is not rescued.

Expression of Ret^{MEN2B.Scer\UAS} under the control of Scer\GAL4^Mhc.PK (limited to the pharate adult stages onwards using Scer\GAL80^ts.αTub84B) does not suppress the muscle morphology phenotype seen in the indirect flight muscles of park¹/park²⁵ mutants.

Expression of Ret^{MEN2B.Scer\UAS} under the control of Scer\GAL4^ple.PF does not suppress the mitochondrial morphology defects seen in park¹/park²⁵ mutant dopaminergic neurons.

(Klein et al., 2014)

Overexpression of Ucp4A^Scer\UAS.cWa by Scer\GAL4^Act.PU reduces thoracic indentations, locomotor defects, male sterility, degeneration (cell death) and disorganization and fewer mitochondrial cristae in indirect flight muscle in park¹/park¹ flies.

(Wu et al., 2014)

The mitochondria morphological defects seen in park¹/park^Δ21 adults are not rescued by Acon¹/+ or Acon^MB09176/+.

(Esposito et al., 2013)

park¹ suppresses the enlarged brain phenotype seen in l(2)gl¹/l(2)gl⁴ mutant third instar larvae.

The brains of clu¹⁶⁹ park¹ double mutant flies are similar in size to wild type.

(Goh et al., 2013)

Expression of either rictor^Scer\UAS.cHa or trc^{S292E.Scer\UAS} under the control of Scer\GAL4^da.PU fails to rescue the abnormal wing posture and mitochondrial aggregation phenotypes seen in park¹/park^Δ21 flies.

(Wu et al., 2013)

GstO2¹/park¹ double mutants show dramatically enhanced degeneration of the indirect flight muscles compared with park¹ single mutants.

20-day-old park¹/GstO2¹ double mutants show significantly increased DA neuron degeneration in the PPL1 cluster compared to park¹ single mutants of the same age, whereas there is no difference in neuronal degeneration between park¹/GstO2¹ double mutants and park¹ single mutants in 1-day-old flies.

Expression of GstO2^A.Scer\UAS using the muscle-specific driver Scer\GAL4^how-24B significantly suppresses both the thorax and downturned wing phenotypes found in park¹ mutants.

Expression of GstO2^B.Scer\UAS using the muscle-specific driver Scer\GAL4^how-24B does not affect either of the thorax and downturned wing phenotypes found in park¹ mutants.

Expression of GstO1^Scer\UAS.cKa using the muscle-specific driver Scer\GAL4^how-24B does not affect either of the thorax and downturned wing phenotypes found in park¹ mutants.

Expression of GstO2^{C31A.A.Scer\UAS} using the muscle-specific driver Scer\GAL4^how-24B does not affect either of the thorax and downturned wing phenotypes found in park¹ mutants.

Overexpression of GstO2^A.Scer\UAS under the control of Scer\GAL4^αTub84B.PL, a ubiquitous driver, suppresses the degeneration of IFMs in park¹ mutants. Overexpression results in regular and compact muscle tissues in the dorsal longitudinal IFMs, which are similar to those of wild-type flies except for occasional vacuoles. Overexpression of GstO2^A.Scer\UAS appears to prevent degeneration of the IFMs by blocking the activation of the JNK pathway and apoptosis in park¹ mutants.

Overexpression of GstO2^A.Scer\UAS under the control of Scer\GAL4^ple.PF results in significant restoration of the lost DA neurons in 20-day-old park¹ mutant flies.

Expression of ATPsyn-β^NIG.11154R at 18[o]C in the muscle, under the control of Scer\GAL4^how-24B enhances the downturned wing and collapsed thorax phenotype found in park¹ mutants, compared to park¹ single mutants.

(Kim et al., 2012)

Expression of Sirt1^Scer\UAS.cGa driven by Scer\GAL4^arm.PU does not suppress phenotypes (collapsed thorax, downturned wings, swollen mitochondria along with increased cell death and reduced levels of mtDNA and ATP in the indirect flight muscle and locomotor defects) seen in Pink1^B9/Y flies.

(Koh et al., 2012)

Expression of SNF1A^TD.Scer\UAS under the control of Scer\GAL4^how-24B suppresses the mitochondrial abnormalities and climbing ability defects seen in park¹ mutant flies. The wing posture defects seen in park¹ mutant flies are also rescued.

(Ng et al., 2012)

Mitochondria are noticeably clustered in the follicles of park¹/+ ; clu^EP969/+ females, although both male and female park¹/+ ; clu^EP969/+ animals are fertile.

(Cox and Spradling, 2009)

Expression of park^{Scer\UAS.T:Zzzz\FLAG,T:Hsap\COX4I1} under the control of Scer\GAL4^hs.PB suppresses the mitochondrial swelling phenotype in Pink1^B9, park¹ double mutants to a great extent.

Expression of park^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^hs.PB partially suppresses the mitochondrial swelling phenotype in Pink1^B9, park¹ double mutants.

Expression of park^{T187A.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^hs.PB partially suppresses the mitochondrial swelling phenotype in Pink1^B9, park¹ double mutants.

(Kim et al., 2008)

The defective wing and thorax phenotypes seen in park¹ mutant flies are not rescued by expression of Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^hs.PB. Expression of Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^hs.PB also fails to rescue the enlarged mitochondria and apoptotic muscle cells seen in adult park¹ thoracic muscles.

The thoracic muscle defects seen in park¹ Pink1^B9 double mutant flies are not increased in severity compared to either single mutant.

(Park et al., 2006)

Xenogenetic Interactions

Statement

Reference

Overexpression of Pink1^{Scer\UAS.T:Ivir\HA1} in heterozygous park¹ flies which also express Scer\GAL4^elav.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS} fails to increase life span.

Overexpression of Pink1^{Scer\UAS.T:Ivir\HA1} in heterozygous park¹ flies which also express Scer\GAL4^elav.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS} fails to provide protection against photoreceptor degeneration.

(Khalil et al., 2015)

Scer\NDI1^Scer\UAS.cVa in the absence of a Scer\GAL4 driver does not suppress the sterility of park¹/park^Δ21 males (even though Scer\NDI1^Scer\UAS.cVa in the absence of a Scer\GAL4 driver does suppress the male sterility of Pink1^B9 males).

Expression of Scer\NDI1^Scer\UAS.cVa under the control of Scer\GAL4^da.G32 does not suppress the flight defects or defects in mitochondrial morphology which are seen in park¹/park^Δ21 flies.

(Vilain et al., 2012)

Scer\GAL4^Ddc.PL-mediated expression of Hsap\PARK2^{R275W.Scer\UAS} does not affect the reduction in dopaminergic neurons in the PPL1 and PAM clusters seen in 20-day old park¹ flies.

Scer\GAL4^Ddc.PL-mediated expression of Hsap\PARK2^WT.Scer\UAS significantly protects against the degeneration of PPL1 and PAM dopaminergic neurons normally seen in 20-day old park¹ flies.

park¹ flies that also carry Scer\GAL4^Ddc.PL, Hsap\PARK2^{R275W.Scer\UAS} are poorer climbers than either single genotype alone.

The mitochondrial defects seen in park¹ indirect flight muscles are significantly mitigated by Scer\GAL4^how-24B-mediated expression of Hsap\PARK2^WT.Scer\UAS.

The mitochondrial defects seen in park¹ indirect flight muscles persist when Hsap\PARK2^{R275W.Scer\UAS} is expressed using Scer\GAL4^how-24B.

(Wang et al., 2007)

Complementation and Rescue Data

Rescued by

park^Δ21/park¹ is rescued by Scer\GAL4^da.PU/park^UAS.cSa

(Shiba-Fukushima et al., 2014)

park^Δ21/park¹ is rescued by park^UAS.cSa/Scer\GAL4^Mhc.PU

(Shiba-Fukushima et al., 2014)

park¹ is rescued by park^UAS.Tag:MYC

(Kim et al., 2008)

park¹ is rescued by park^UAS.Tag:MYC/Scer\GAL4^Ddc.PL

(Cha et al., 2005)

Partially rescued by

park^Δ21/park¹ is partially rescued by park^SA.UAS/Scer\GAL4^Mhc.PU

(Shiba-Fukushima et al., 2014)

park¹ is partially rescued by park^{T187A.UAS.Tag:MYC}

(Kim et al., 2008)

Not rescued by

park^Δ21/park¹ is not rescued by Scer\GAL4^da.PU/park^SA.UAS

(Shiba-Fukushima et al., 2014)

Comments

Expression of park^Scer\UAS.cSa under the control of Scer\GAL4^da.PU rescues the mitochondria phenotype seen in park^Δ21/park¹ mutant indirect flight muscles. The reduction in ATP levels is also rescued, and is improved to a level higher than that of controls.

Expression of park^Scer\UAS.cSa under the control of Scer\GAL4^Mhc.PU rescues the wing posture and thorax defects seen in park^Δ21/park¹ mutant flies.

Expression of park^SA.Scer\UAS under the control of Scer\GAL4^da.PU fails to rescue the mitochondria phenotype seen in park^Δ21/park¹ mutant indirect flight muscles. The reduction in ATP levels is rescued, and is improved to a level higher than that of controls.

Expression of park^SA.Scer\UAS under the control of Scer\GAL4^Mhc.PU partially rescues the wing posture and thorax defects seen in park^Δ21/park¹ mutant flies. The reduction in ATP levels is also improved.

Expression of park^SE.Scer\UAS under the control of Scer\GAL4^da.PU results in lethality, either in a park^Δ21/park¹ or wild type mutant background.

(Shiba-Fukushima et al., 2014)

The mitochondrial morphology in the indirect flight muscle of park¹ mutants is fully rescued by expression of park^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^hs.PB

The mitochondrial morphology in the indirect flight muscle of park¹ mutants is partially rescued by expression of park^{T187A.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^hs.PB

(Kim et al., 2008)

The park¹ dorsomedial dopaminergic neuron morphology and loss phenotype can be completely rescued by the expression of park^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^Ddc.PL.

(Cha et al., 2005)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

34747

w^*; P{EP}park¹/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

Dpark¹

(Lee et al., 2011)

Park¹

(Liu et al., 2022, Erhardt et al., 2021, Chen et al., 2017, Navarro et al., 2014)

Parkin¹

(Huang et al., 2022, Wu et al., 2018, Meng et al., 2017, Shiba-Fukushima et al., 2017, Shiba-Fukushima et al., 2014)

dparkin¹

(Wu et al., 2019)

park1

(Basil et al., 2017)

parkin¹

(Valadas et al., 2018, Brooks et al., 2016, Wang et al., 2016, Gehrke et al., 2015, Wang et al., 2015, Esposito et al., 2013, Koh et al., 2012, Vilain et al., 2012)

pk1

(Basil et al., 2017)

Name Synonyms

parkin-null

(Ng et al., 2012)

Secondary FlyBase IDs

References (57)

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