Allele Dmel\CheB42a^Δ5-68

General Information
Symbol	Dmel\CheB42a^Δ5-68	Species	D. melanogaster
Name		FlyBase ID	FBal0189632
Feature type	allele	Associated gene	Dmel\CheB42a

Allele class
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	P-element activity (Lin et al., 2005)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{SUPor-P}mim^KG05881 (Lin et al., 2005)
Nature of the lesion	Statement Reference Imprecise excision of P{SUPor-P}KG05881 generates a genomic deletion removing the 5' section and upstream promoter regions of CheB42a. (Lin et al., 2005)
Cytology
Phenotypic Data
Phenotypic Class
	mating rhythm defective (Park et al., 2006) taste perception defective (Park et al., 2006)
Phenotype Manifest In

Detailed Description
	Statement Reference CheB42a^Δ5-68 mutant males perform an average of eight attempted copulations in a 10 min observation period, whereas control males perform only three. This increased number results from a faster progression from initiation of courtship behaviour to the first attempted copulation, as well as more frequent subsequent attempts. CheB42a^Δ5-68 males are not different from controls in the timing or frequency of earlier steps in the courtship sequence (lag to courtship initiation, tracking and following of the female, tapping, and wing vibration). CheB42a^Δ5-68 homozygous males spend the same amount of time courting females as wild-type controls. CheB42a^Δ5-68 has no effect on several other behaviours unrelated to courtship; such behaviours include preening, walking, geotaxis, and gustatory response to sugars. (Park et al., 2006) Males homozygous for CheB42a^Δ5-68 display normal levels of overall courtship. The typical climbing response to mechanosensory detection of gravity, stimulation of food intake by gustatory detection of sucrose is not affected in CheB42a^Δ5-68 homozygous males. (Lin et al., 2005)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference CheB42a^Δ5-68 has mating rhythm defective phenotype, enhanceable \| male limited by Scer\GAL4^oeE/tra^Scer\UAS.cFa (Park et al., 2006) CheB42a^Δ5-68 has taste perception defective phenotype, enhanceable \| male limited by Scer\GAL4^oeE/tra^Scer\UAS.cFa (Park et al., 2006)
Suppressed by
Statement Reference CheB42a^Δ5-68 has mating rhythm defective phenotype, suppressible \| female limited by tra^Scer\UAS.cFa/Scer\GAL4^hs.PB (Park et al., 2006) CheB42a^Δ5-68 has taste perception defective phenotype, suppressible \| female limited by tra^Scer\UAS.cFa/Scer\GAL4^hs.PB (Park et al., 2006)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference In contrast to their different responses to wild-type females, CheB42a^Δ5-68 and wild-type males attempt to copulate with heat-shocked females expressing tra^Scer\UAS.cFa under the control of Scer\GAL4^hs.PB with indistinguishable frequency and kinetics, suggesting that the behavioural effect of CheB42a depends on the presence of the major female cuticular hydrocarbons. Partially-transformed males, where tra^Scer\UAS.cFa under the control of Scer\GAL4^oeE is expressed in the oenocytes, elicit significant courtship responses both from controls and CheB42a^Δ5-68 males. Mutant males outperform controls specifically in the kinetics and frequency of attempted copulations. (Park et al., 2006)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	CheB42a^Δ5-68 is rescued by CheB42a^+tTg1 (Park et al., 2006)
Not rescued by	CheB42a^Δ5-68 is not rescued by CheB42a^ATGmut.+tTg1 (Park et al., 2006)
Comments	CheB42a^Δ5-68 rescues the accelerated progression towards attempted copulation and its increased frequency found in CheB42a^Δ5-68 males. (Park et al., 2006)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CheB42a^Δ5-68
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Park et al., 2006, Curr. Biol. 16(11): 1154--1159 A Drosophila protein specific to pheromone-sensing gustatory hairs delays males' copulation attempts. [FBrf0195097] Lin et al., 2005, Proc. Natl. Acad. Sci. U.S.A. 102(36): 12831--12836 A Drosophila DEG/ENaC channel subunit is required for male response to female pheromones. [FBrf0188263]

Allele Dmel\CheB42aΔ5-68

Allele Dmel\CheB42a^Δ5-68