Allele Hsap\ATXN1L^{Scer\UAS.T:Zzzz\FLAG}

General Information
Symbol	Hsap\ATXN1L^{Scer\UAS.T:Zzzz\FLAG}	Species	H. sapiens
Name		FlyBase ID	FBal0189668
Feature type	allele	Associated gene	Hsap\ATXN1L

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Mizutani et al., 2005) in vitro construct - regulatory fusion (Mizutani et al., 2005)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Scer\UAS sequences drive expression of full-length Hsap\Boat, tagged with T:Zzzz\FLAG. (Mizutani et al., 2005)
Carried in construct	P{UAS-Hsap\Boat.FLAG} (Mizutani et al., 2005)
Tagged with	T:Zzzz\FLAG (Mizutani et al., 2005)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference Expression of Hsap\Boat^{Scer\UAS.T:Zzzz\FLAG}, under the control of Scer\GAL4^GMR.PF, has no affect on eye morphology. (Mizutani et al., 2005)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement Reference Hsap\ATXN1L^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PF, Scer\GAL4^GMR.PF is a suppressor of pigment cell phenotype of Hsap\ATXN1^82.Scer\UAS (Mizutani et al., 2005) Hsap\ATXN1L^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Hsap\ATXN1^82.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mizutani et al., 2005) Hsap\ATXN1L^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a suppressor of interommatidial bristle phenotype of Hsap\ATXN1^82.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mizutani et al., 2005)
NOT Suppressor of
Statement Reference Hsap\ATXN1L^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mizutani et al., 2005) Hsap\ATXN1L^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} (Mizutani et al., 2005)
Other
Statement Reference Hsap\ATXN1^82.Scer\UAS, Hsap\ATXN1L^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has interommatidial bristle phenotype (Mizutani et al., 2005, Mizutani et al., 2005)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference Expression of two copies of the Hsap\Boat^{Scer\UAS.T:Zzzz\FLAG} transgene, under the control of Scer\GAL4^GMR.PF, suppresses the Scer\GAL4^GMR.PF>Hsap\ATX1^82.Scer\UAS-induced eye phenotype. These flies show a restoration of bristle formation, pigmentation, and overall eye structure. However, there is also a gain-of-function phenotype, with rescued eyes showing thicker and longer bristles. The eye phenotypes caused by expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} or Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF, are not suppressed by coexpression of Hsap\Boat^{Scer\UAS.T:Zzzz\FLAG}. (Mizutani et al., 2005)
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Hsap\ATXN1L^{Scer\UAS.T:Zzzz\FLAG} Hsap\Boat^{Scer\UAS.T:Zzzz\FLAG}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Mizutani et al., 2005, EMBO J. 24(18): 3339--3351 Boat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1. [FBrf0187513]

Allele Hsap\ATXN1LScer\UAS.T:Zzzz\FLAG

Allele Hsap\ATXN1L^{Scer\UAS.T:Zzzz\FLAG}