Allele Dmel\aop⁴⁴³

General Information
Symbol	Dmel\aop⁴⁴³	Species	D. melanogaster
Name		FlyBase ID	FBal0189749
Feature type	allele	Associated gene	Dmel\aop
Also Known As	yan⁴⁴³

Map ( GBrowse )
Allele class	loss of function allele
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	loss of function allele (Schober et al., 2005)
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 2L:2,160,161..2,160,161 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=C2160161T pr_change=Q111\|aop-PB,Q111\|aop-PA reported_pr_change=Q111@ (Schober et al., 2005)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: Q111@. The above mutation deleted most of the protein including the MAPK phosphorylation sites and the entire ETS DNA-binding domain. (Schober et al., 2005)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	border follicle cell \| somatic clone (Schober et al., 2005)
Detailed Description
	Statement Reference The majority of border cells in egg chambers with aop⁴⁴³ mutant clones fail to migrate. The border cells are connected laterally to squamous follicle cells, suggesting that they remain attached to the anterior follicular epithelium. (Schober et al., 2005)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference aop⁴⁴³/aop[+] is an enhancer of planar polarity defective phenotype of Scer\GAL4^hs.2sev, dgo^Scer\UAS.cFa (Weber et al., 2012)
Phenotype Manifest In
Enhancer of
Statement Reference aop⁴⁴³/aop[+] is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, dgo^Scer\UAS.cFa (Weber et al., 2012)
NOT Enhancer of
Statement Reference aop⁴⁴³/aop[+] is a non-enhancer of wing hair phenotype of Scer\GAL4^hs.2sev, dgo^Scer\UAS.cFa (Weber et al., 2012)
NOT Suppressor of
Statement Reference aop⁴⁴³/aop[+] is a non-suppressor of wing hair phenotype of Scer\GAL4^hs.2sev, dgo^Scer\UAS.cFa (Weber et al., 2012)
Additional Comments
Genetic Interactions
Statement Reference aop[443]/+ enhances the planar cell polarity (PCP) defects in the eye induced by the overexpression of dgo[Scer\UAS.cFa] under the control of Scer\GAL4[hs.2sev]. (Weber et al., 2012)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer
	Selected as: a modifier of Ras85D in the eye in a genetic screen. (Schober et al., 2005)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	aop⁴⁴³ (Weber et al., 2012) yan⁴⁴³ (Schober et al., 2005, Letizia et al., 2007, Olson et al., 2011) yan^E433 (Weber et al., 2008)
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Weber et al., 2012, Genetics 191(1): 145--162 Novel regulators of planar cell polarity: a genetic analysis in Drosophila. [FBrf0218210] Olson et al., 2011, EMBO Rep. 12(10): 1047--1054 Yan, an ETS-domain transcription factor, negatively modulates the Wingless pathway in the Drosophila eye. [FBrf0216277] Weber et al., 2008, Dev. Biol. 316(1): 110--123 Combinatorial signaling by the Frizzled/PCP and Egfr pathways during planar cell polarity establishment in the Drosophila eye. [FBrf0204109] Letizia et al., 2007, Development 134(7): 1337--1346 Antagonistic and cooperative actions of the EGFR and Dpp pathways on the iroquois genes regulate Drosophila mesothorax specification and patterning. [FBrf0194844] Schober et al., 2005, Development 132(15): 3493--3504 Function of the ETS transcription factor Yan in border cell migration. [FBrf0187480]

Allele Dmel\aop443

Allele Dmel\aop⁴⁴³