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General Information
Symbol
Dmel\aop443
Species
D. melanogaster
Name
FlyBase ID
FBal0189749
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
yan443, yanER443
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    point mutation
    Nucleotide change:
    C2160161T
    Amino acid change:
    Q111term | aop-PA; Q111term | aop-PB; Q111term | aop-PC; Q111term | aop-PD; Q111term | aop-PE
    Reported amino acid change:
    Q111term
    Comment:
    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    The premature stop codon is predicted to result in a truncated protein that lacks most of the wild-type sequence including the MAPK phosphorylation sites and the entire ETS DNA-binding domain.
    Amino acid replacement: Q111term.
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference
    Adult aop443/aopE833 transheterozygotes bearing aopV105R.GFP show a rough eye phenotype; most ommatidia show extra photoreceptor cells, particularly inner photoreceptor R7 cells, but some other miss photoreceptor cells, as compared to controls.
    The majority of border cells in egg chambers with aop443 mutant clones fail to migrate. The border cells are connected laterally to squamous follicle cells, suggesting that they remain attached to the anterior follicular epithelium.
    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhancer of
    Statement
    Reference
    Phenotype Manifest In
    Enhancer of
    Statement
    Reference
    aop443/aop[+] is an enhancer of ommatidium phenotype of Scer\GAL4hs.2sev, dgoUAS.cFa
    NOT Enhancer of
    Statement
    Reference
    aop443/aop[+] is a non-enhancer of wing hair phenotype of Scer\GAL4hs.2sev, dgoUAS.cFa
    NOT Suppressor of
    Statement
    Reference
    aop443/aop[+] is a non-suppressor of wing hair phenotype of Scer\GAL4hs.2sev, dgoUAS.cFa
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    aop443/+ enhances the planar cell polarity (PCP) defects in the eye induced by the overexpression of dgoScer\UAS.cFa under the control of Scer\GAL4hs.2sev.
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    Selected as: a modifier of Ras85D in the eye in a genetic screen.
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (6)
    References (8)