FlyBase Allele Report: Dmel\Gcn5[ΔT280-F285]

General Information

Symbol

Dmel\Gcn5^ΔT280-F285

Species

D. melanogaster

Name

FlyBase ID

FBal0189826

Feature type

allele

Associated gene

Dmel\Gcn5

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

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Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Carre et al., 2005)

Mutagen

ethyl methanesulfonate

(Carre et al., 2005)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

deletion

3L:12,523,049..12,523,066 [-]

Comment:

Reported as a small deletion from tyrosine 280 to phenylalanine 285.

(Carre et al., 2005)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

A a small deletion from T280 to F285 of Pcaf.

(Carre et al., 2005)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(3L)sex204)

(Carre et al., 2005)

lethal | recessive

(Carre et al., 2005)

partially lethal - majority die (with Gcn5^E333st)

(Carre et al., 2005)

some die during pharate adult stage (with Gcn5^E333st)

(Carre et al., 2005)

Phenotype Manifest In

adult cuticle & adult abdomen (with Gcn5^E333st)

(Carre et al., 2005)

cuticle & abdomen & pharate adult (with Gcn5^E333st)

(Carre et al., 2005)

eye (with Gcn5^E333st)

(Carre et al., 2005)

metathoracic leg (with Gcn5^E333st)

(Carre et al., 2005)

metathoracic leg | pharate adult stage (with Gcn5^E333st)

(Carre et al., 2005)

ommatidium (with Gcn5^E333st)

(Carre et al., 2005)

wing (with Gcn5^E333st)

(Carre et al., 2005)

Detailed Description

Statement

Reference

Pcaf^E333st/Pcaf^ΔT280-F285 animals form their puparium normally, but during pupation they fail to elongate their metathoracic legs correctly and to deposit some or all abdominal cuticle. Rare adult escapers have misshapen wings, rough eyes, and crooked and twisted metathoracic legs and die a few hours after eclosion.

(Carre et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Gcn5[+]/Gcn5^ΔT280-F285 is a suppressor | partially of visible phenotype of Scer\GAL4^Ser.PGF, Sin3A^{dsRNA.UAS.WIZ}

(Swaminathan and Pile, 2010)

Phenotype Manifest In

Suppressor of

Statement

Reference

Gcn5[+]/Gcn5^ΔT280-F285 is a suppressor | partially of wing blade phenotype of Scer\GAL4^Ser.PGF, Sin3A^{dsRNA.UAS.WIZ}

(Swaminathan and Pile, 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Gcn5^ΔT280-F285/+ partially suppresses the wing phenotype induced by Scer\GAL4^Ser.PGF>Sin3A^{dsRNA.Scer\UAS.WIZ}.

(Swaminathan and Pile, 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Df(3L)sex204/Gcn5^ΔT280-F285 is rescued by Gcn5^UAS.cCa/Scer\GAL4^da.G32

(Carre et al., 2005)

Df(3L)sex204/Gcn5^ΔT280-F285 is rescued by Gcn5^+t4.7

(Carre et al., 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

9336

y¹ w¹¹¹⁸; Gcn5^ΔT280-F285 P{FRT(w^hs)}2A e¹/TM3, P{ActGFP}JMR2, Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Gcn5^ΔT280-F285

Pcaf DeltaT280-F285

(Swaminathan and Pile, 2010)

Pcaf ΔT280-F285

(Swaminathan and Pile, 2010)

Pcaf^ΔT280-F285

(Swaminathan and Pile, 2010)

gcn5^{deltT280-F285}

(Liu et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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