FlyBase Allele Report: Dmel\Gcn5[ΔT280-F285]

General Information

Symbol

Dmel\Gcn5^ΔT280-F285

Species

D. melanogaster

Name

FlyBase ID

FBal0189826

Feature type

allele

Associated gene

Dmel\Gcn5

Associated Insertion(s)

Carried in Construct

Genomic Maps

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Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Carre et al., 2005)

Mutagen

ethyl methanesulfonate

(Carre et al., 2005)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

deletion

3L:12,523,049..12,523,066 [-]

Comment:

Reported as a small deletion from tyrosine 280 to phenylalanine 285.

(Carre et al., 2005)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

A a small deletion from T280 to F285 of Pcaf.

(Carre et al., 2005)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

lethal (with Df(3L)sex204)

(Carre et al., 2005)

lethal | recessive

(Carre et al., 2005)

partially lethal - majority die (with Gcn5^E333st)

(Carre et al., 2005)

some die during pharate adult stage (with Gcn5^E333st)

(Carre et al., 2005)

Phenotype Manifest In

adult cuticle & adult abdomen (with Gcn5^E333st)

(Carre et al., 2005)

cuticle & abdomen & pharate adult (with Gcn5^E333st)

(Carre et al., 2005)

eye (with Gcn5^E333st)

(Carre et al., 2005)

metathoracic leg (with Gcn5^E333st)

(Carre et al., 2005)

metathoracic leg | pharate adult stage (with Gcn5^E333st)

(Carre et al., 2005)

ommatidium (with Gcn5^E333st)

(Carre et al., 2005)

wing (with Gcn5^E333st)

(Carre et al., 2005)

Detailed Description

Statement

Reference

Pcaf^E333st/Pcaf^ΔT280-F285 animals form their puparium normally, but during pupation they fail to elongate their metathoracic legs correctly and to deposit some or all abdominal cuticle. Rare adult escapers have misshapen wings, rough eyes, and crooked and twisted metathoracic legs and die a few hours after eclosion.

(Carre et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Gcn5[+]/Gcn5^ΔT280-F285 is a suppressor | partially of visible phenotype of Scer\GAL4^Ser.PGF, Sin3A^{dsRNA.UAS.WIZ}

(Swaminathan and Pile, 2010)

Phenotype Manifest In