Allele Dmel\psq^rev4

General Information
Symbol	Dmel\psq^rev4	Species	D. melanogaster
Name		FlyBase ID	FBal0189830
Feature type	allele	Associated gene	Dmel\psq

Map ( GBrowse )
Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Ferres-Marco et al., 2006)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 2R:6,499,587..6,499,587 evidence=experimental na_change=C6499587T pr_change=Q530\|psq-PC,Q530\|psq-PA,Q105\|psq-PI,Q105\|p sq-PJ,Q105\|psq-PK,Q111\|psq-PH,Q111\|psq-PG,Q111\|psq-PD, Q111\|psq-PF,Q530\|psq-PB,Q111@\|psq-PE reported_pr_change=Q530@ comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. The P{GSV1}lola^GS88A8 insertion is still present on the chromosome. (Ferres-Marco et al., 2006)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	psq^GS88A8 (Ferres-Marco et al., 2006)
Nature of the lesion	Statement Reference Amino acid replacement: Q530. The P{GSV1}lola^GS88A8@ insertion is still present on the chromosome. (Ferres-Marco et al., 2006)
Caused by insertion	P{GSV1}lola^GS88A8 (Ferres-Marco et al., 2006)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference Flies expressing Dl^Scer\UAS.cDa under the control of Scer\GAL4^ey.PH and also carrying lola^GS88A8 and psq^rev4 do not produce eye tumours or metastases. (Ferres-Marco et al., 2006)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer
	Induced on: the P{GSV1}lola^GS88A8 chromosome. Selected as: a mutation that reverts the tumour phenotype caused by overexpression of both psq and lola from the P{GSV1}lola^GS88A8 insertion under the control of Scer\GAL4^ey.PH in the presence of Dl^Scer\UAS.cDa. (Ferres-Marco et al., 2006)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	psq^rev4 (Grillo et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Grillo et al., 2011, Genetics 187(2): 513--521 Control of Germline torso Expression by the BTB/POZ Domain Protein Pipsqueak Is Required for Embryonic Terminal Patterning in Drosophila. [FBrf0213010] Ferres-Marco et al., 2006, Nature 439(7075): 430--436 Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing. [FBrf0191239]

Allele Dmel\psqrev4

Allele Dmel\psq^rev4