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General Information
Symbol
Dmel\Sec8Δ1
Species
D. melanogaster
Name
FlyBase ID
FBal0189884
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the P{SUPor-P} element; has a deletion that begins 37bp into the first 5' exon and ends 73bp prior to the 3' end of the last exon.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

synapse & microtubule

Detailed Description
Statement
Reference

sec8Δ1 mutants hatch at the normal time and initially appear normal in size and behaviour. However, these mutants fail to undergo their first molt and die as first instar larvae. NMJ morphology appears normal in L1 sec8Δ1 mutants. The frequency of spontaneous synaptic currents from these NMJs is normal but the amplitude is mildly but significantly reduced compared to wild type. Glutamate-gated current amplitude is also reduced in these mutants. The amplitude of delayed synaptic receptor closings is not significantly different in the mutants to wild type, indicating that the decrease in glutamate-gated current is due to a loss of functional postsynaptic receptors, rather than a change in receptor properties. The cluster size of both A- and B-type glutamate receptors is significantly reduced in sec8Δ1 first instar larvae. Synaptic microtubule density is significantly increased in sec8Δ1 larvae.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Not rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
CG2095Δ1
Sec8Δ1
sec8Δ1
Name Synonyms
Secondary FlyBase IDs
    References (3)