|Feature type||allele||Associated gene||Dmel\Sh|
|Mutagen||in vitro construct - deletion|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Carried in construct|
|Phenotype Manifest In|
When ShSDN.Scer\UAS.T:Avic\GFP-GL is driven by Scer\GAL4Mhc.Switch.PO or Scer\GAL4elav.Switch.PO, and the animals exposed to RU486, no significant reduction in viability is seen. When ShSDN.Scer\UAS.T:Avic\GFP-GL is driven by Scer\GAL4Mhc.Switch.PO , and the animals exposed to RU486, the voltage-activated transient K+ current (IA) in the larval muscle fibres is potently suppressed. IK is unaffected. The frequency of spontaneous synaptic activity in ShSDN.Scer\UAS.T:Avic\GFP-GL, Scer\GAL4elav.Switch.PO mutants exposed to RU486, is nearly twice that of wild-type. Excitatory postsynaptic potential (EPSP) duration is increased by ~49% when Scer\GAL4elav.Switch.PO is driven by Scer\GAL4elav.Switch.PO and exposed to RU486. When driven by Scer\GAL4Mhc.Switch.PO, a 37% increase is seen. EPSP amplitude is unaffected. Mutant adults exhibit both leg shaking and wing scissoring under ether anaesthetization, when driven by Scer\GAL4Mhc.Switch.PO or Scer\GAL4Mhc.Switch.PO and exposed to RU486. This behaviour persists in severed legs. When ShSDN.Scer\UAS.T:Avic\GFP-GL is driven by Scer\GAL4Mhc.Switch.PO mutant larvae (also exposed to RU486) crawl more slowly than wild-type. This affect is not seen if driven by Scer\GAL4elav.Switch.PO. When ShSDN.Scer\UAS.T:Avic\GFP-GL is driven by Scer\GAL4elav.Switch.PO or Scer\GAL4Mhc.Switch.PO and mutants are exposed to RU486 no effect is seen on arborisation.
Scer\GAL4elav.Switch.PO, ShSDN.Scer\UAS.T:Avic\GFP-GL has hyperactive | RU486 conditional phenotype, suppressible by mlenap-ts1
|Phenotype Manifest In|
When ShSDN.Scer\UAS.T:Avic\GFP-GL is driven by Scer\GAL4Mhc.Switch.PO in a eag1 and mutants are exposed to RU486 no effect is seen on arborisation. If driven by Scer\GAL4elav.Switch.PO in a eag1 background synaptic arbor growth is significantly increased. The mean bouton count in NMJ boutons is almost doubled in these mutants.
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 1 )|
|Secondary FlyBase IDs|
|References ( 1 )|