FlyBase Allele Report: Dmel\Ret[MEN2A.GMR]

General Information

Symbol

Dmel\Ret^MEN2A.GMR

Species

D. melanogaster

Name

FlyBase ID

FBal0189983

Feature type

allele

Associated gene

Dmel\Ret

Associated Insertion(s)

Carried in Construct

P{GMR-Ret.MEN2A}

Also Known As

GMR-dRet^MEN2A

Key Links

Genomic Maps

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Allele class

Mutagen

in vitro construct - amino acid replacement

Nature of the Allele

Allele class

Mutagen

in vitro construct - amino acid replacement

(Read et al., 2005)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

point_mutation

2L:21,184,913..21,184,913 [-]

Nucleotide change:

T21184913C

Reported nucleotide change:

T?C

Amino acid change:

C695R | Ret-PB; C695R | Ret-PA; C695R | Ret-PC

Reported amino acid change:

C695R

Comment:

Analogous mutation in human RET implicated in multiple endocrine neoplasia, type IIA; mutation carried on in vitro construct.

(Read et al., 2005)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Ret^GMR.PR

(Read et al., 2005)

Carried in construct

P{GMR-Ret.MEN2A}

Cytology

Nature of the lesion

Statement

Reference

Amino acid replacement: C695R. Nucleotide substitution: C?T.

(Read et al., 2005)

Allele components

Product class / Tool use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

Ret

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of multiple endocrine neoplasia type 2A

CEA

(Read et al., 2005)

model of familial medullary thyroid carcinoma

CEA

(Vidal et al., 2005)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of multiple endocrine neoplasia type 2A

is ameliorated by kis^k10237

(Read et al., 2005)

is exacerbated by Mi-2^S005504

(Read et al., 2005)

is ameliorated by S^k09538a

(Read et al., 2005)

is exacerbated by Sin3A^ex4

(Read et al., 2005)

is exacerbated by msn^j1E2

(Read et al., 2005)

is ameliorated by S^IIN

(Read et al., 2005)

is exacerbated by Mi-2^S147412

(Read et al., 2005)

is ameliorated by spi¹

(Read et al., 2005)

is exacerbated by Sin3A⁰⁸²⁶⁹

(Read et al., 2005)

is ameliorated by Ras85D⁰⁶⁶⁷⁷

(Read et al., 2005)

is ameliorated by Dl^S049520

(Read et al., 2005)

is exacerbated by hh^rJ413

(Read et al., 2005)

is ameliorated by Dl^9P

(Read et al., 2005)

is ameliorated by ebi^k16213

(Read et al., 2005)

is ameliorated by spi^s3547

(Read et al., 2005)

is ameliorated by drk¹⁰⁶²⁶

(Read et al., 2005)

is exacerbated by hh²

(Read et al., 2005)

is ameliorated by Fak^UAS.Tag:HA

(Macagno et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

This allele represents a human variant implicated in disease.

(Read et al., 2005)

RET:p.Cys634Arg

(FlyBase curators, 2019-)

Variants Synonym(s)

RET:p.Cys380Arg

Associated human disease model(s)

multiple endocrine neoplasia, type IIA

External database links

ClinVar: RET_13917

Comments concerning this variant

Phenotypic Data

Phenotypic Class

abnormal size | adult stage

(Vidal et al., 2005)

visible

(Macagno et al., 2014, Aron et al., 2010, Read et al., 2005, Vidal et al., 2005)

Phenotype Manifest In

cone cell | pupal stage | increased number

(Macagno et al., 2014)

eye

(Macagno et al., 2014, Read et al., 2005, Vidal et al., 2005)

eye | adult stage

(Aron et al., 2010)

ommatidium

(Read et al., 2005)

retina

(Macagno et al., 2014)

Detailed Description

Statement

Reference

Expression of Ret^MEN2A.GMR results in a rough eye phenotype. Doubling the dose of Ret^MEN2A.GMR causes a very rough and small eye.

The retinas of pupae expressing two copies of Ret^MEN2A.GMR are primarily composed of ct- positive cone-like cells, and the few remaining cells display bristle morphology.

(Macagno et al., 2014)

Ret^MEN2A.GMR flies have small (significant size decrease compared to wild type) rough eyes.

(Aron et al., 2010)

Flies carrying one copy of Ret^MEN2A.GMR have a rough eye phenotype. Flies carrying two copies of Ret^MEN2A.GMR have a severe eye phenotype, with the eye becoming an irregular mass.

(Read et al., 2005)

Expression of Ret^MEN2A.GMR in the developing eye leads to overproliferation, alterations in cell fate differentiation, and ectopic cell death, giving rise to "rough" adult eyes consisting of fused, poorly patterned lenses and a reduction in the eyes' overall size.

(Vidal et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Ret^MEN2A.GMR has visible phenotype, enhanceable by Df(1)B25/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by Df(1)sd72b/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by Df(2L)H20/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by Df(2L)TW137/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by Df(2L)TW50/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by Df(2L)cact-255rv64/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by Df(1)C128/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by Df(2R)CX1/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by Df(2R)P34/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by Df(2R)vg-C/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by Df(3R)M-Kx1/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by Df(3R)T-32/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by Df(3R)e-N19/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by Df(3R)e-R1/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by RasGAP1^B2

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by In(2LR)DTD16^LDTD42^R/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by Mi-2^S005504/Mi-2[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by Df(1)KA14/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by Mi-2^S147412/Mi-2[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by Pp1-87B[+]/Pp1-87B^j6E7

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by Sin3A[+]/Sin3A⁰⁸²⁶⁹

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by Sin3A^ex4

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by bon^S048706/bon[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by crb^j1B5/crb[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by hh²

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by hh[+]/hh^rJ413

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by l(3)S000710[+]/l(3)S000710^S000710

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by l(3)S016805[+]/l(3)S016805^S016805

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by Df(1)RA2/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by l(3)S023549^S023549/l(3)S023549[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by l(3)S023549^S090101/l(3)S023549[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by l(3)S023708[+]/l(3)S023708^S023708

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by l(3)S024329^S024329/l(3)S024329[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by l(3)S024833[+]/l(3)S024833^S024833

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by l(3)S046604^S046604/l(3)S046604[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by l(3)S066607[+]/l(3)S066607^S066607

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by l(3)S068808^S068808/l(3)S068808[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by l(3)S133117[+]/l(3)S133117^S133117

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by l(3)j2D5^j2D5/l(3)j2D5[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by Df(1)lz-90b24/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by l(3)j4B9^j4B9/l(3)j4B9[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by msn[+]/msn^j1E2

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by neur[+]/neur^j6B12

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, enhanceable by scrib[+]/scrib^j7B3

(Read et al., 2005)

NOT Enhanced by

Statement

Reference

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by Mi-2^S047526/Mi-2[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by Pp1-87B¹

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by S^k09530

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by crb^11A22

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by drk^k02401

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by drk^k13809

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by dsh³

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by dsh⁶

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by l(3)S000718[+]/l(3)S000718^S000718

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by l(3)S001405^S001405/l(3)S001405[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by l(3)S003704^S003704/l(3)S003704[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by l(3)S009515[+]/l(3)S009515^S009515

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by l(3)S012805^S012805/l(3)S012805[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by l(3)S019203^S141715/l(3)S019203[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by l(3)S026238^S026238/l(3)S026238[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by l(3)S026421^S026421/l(3)S026421[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by l(3)S056113[+]/l(3)S056113^S056113

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by l(3)S057101[+]/l(3)S057101^S057101

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by l(3)S081003^S145911/l(3)S081003[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by l(3)S090114[+]/l(3)S090114^S090114

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by l(3)S092708[+]/l(3)S092708^S092708

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by l(3)S135703^S135703/l(3)S135703[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by l(3)S142909^S142909/l(3)S142909[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by neur¹¹

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by px[+]/px^k08316

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by stg^S024503/stg[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by tws^S049902/tws[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by Csk^j1D8/Csk[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by CycA^S054513/CycA[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by Df(2R)AA21/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by Df(2R)Pu-D17/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by Df(2R)ST1/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-enhanceable by Df(3L)ZN47/+

(Read et al., 2005)

Suppressed by

Statement

Reference

Ret^MEN2A.GMR has visible phenotype, suppressible | partially by Fak^UAS.Tag:HA/Scer\GAL4^GMR.PU

(Macagno et al., 2014)

Ret^MEN2A.GMR has visible phenotype, suppressible | partially by Fak^Y430F.UAS/Scer\GAL4^GMR.PU

(Macagno et al., 2014)

Ret^MEN2A.GMR has visible phenotype, suppressible by DJ-1alpha[+]/DJ-1α^Δ72, dj-1β^Δ93/dj-1β^Δ93

(Aron et al., 2010)

Ret^MEN2A.GMR has visible phenotype, suppressible by Ras85D⁰⁶⁶⁷⁷

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by S^IIN

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by S[+]/S^k09538a

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by Src42A^k10108

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by Src64B^PI

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by bsk¹

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by bsk²

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by crb⁰⁷²⁰⁷

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by drk¹⁰⁶²⁶

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by ebi[+]/ebi^k16213

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by kis[+]/kis^k10237

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by ksr^S-627

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by ksr^j5E2

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by l(3)06803[+]/l(3)06803⁰⁶⁸⁰³

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by l(3)06906[+]/l(3)06906⁰⁶⁹⁰⁶

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by l(3)S023901[+]/l(3)S023901^S023901

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by l(3)j5B6^j5B6/l(3)j5B6[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by neur^A101

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by scrib¹

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by scrib⁶⁷³

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by spi¹

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by spi^s3547

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by Df(2L)TW161/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by Df(2L)al/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by Df(2L)net-PMF/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by +/Df(2R)59AD

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by Df(2R)X58-12/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by Df(3L)Pc-2q/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by Df(3R)Antp17/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by Df(3R)Cha7/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by Df(3R)DG2/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by +/Df(3R)Dl-BX12

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by Df(3R)Hu/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by Df(3R)ME15/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by Df(3R)by10/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by Dl^9P

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by Dl^S049520/Dl[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by Jra^IA109

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, suppressible by Pp1-87B²

(Read et al., 2005)

NOT suppressed by

Statement

Reference

Ret^MEN2A.GMR has visible phenotype, non-suppressible by Fak^ΔN.UAS/Scer\GAL4^GMR.PU

(Macagno et al., 2014)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by Csk^j1D8/Csk[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by Df(3L)ZN47/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by Mi-2^S047526/Mi-2[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by Pp1-87B¹

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by S^k09530

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by crb^11A22

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by CycA^S054513/CycA[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by drk^k02401

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by drk^k13809

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by dsh³

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by dsh⁶

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by l(3)S000718[+]/l(3)S000718^S000718

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by l(3)S001405^S001405/l(3)S001405[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by l(3)S003704^S003704/l(3)S003704[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by l(3)S009515[+]/l(3)S009515^S009515

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by l(3)S012805^S012805/l(3)S012805[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by l(3)S019203^S141715/l(3)S019203[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by Df(2R)AA21/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by l(3)S026238^S026238/l(3)S026238[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by l(3)S026421^S026421/l(3)S026421[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by l(3)S056113[+]/l(3)S056113^S056113

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by l(3)S057101[+]/l(3)S057101^S057101

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by l(3)S081003^S145911/l(3)S081003[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by l(3)S090114[+]/l(3)S090114^S090114

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by l(3)S092708[+]/l(3)S092708^S092708

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by l(3)S135703^S135703/l(3)S135703[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by l(3)S142909^S142909/l(3)S142909[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by neur¹¹

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by Df(2R)Pu-D17/+

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by px[+]/px^k08316

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by stg^S024503/stg[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by tws^S049902/tws[+]

(Read et al., 2005)

Ret^MEN2A.GMR has visible phenotype, non-suppressible by Df(2R)ST1/+

(Read et al., 2005)

Phenotype Manifest In

Enhanced by

Statement

Reference

Ret^MEN2A.GMR has eye phenotype, enhanceable by Df(1)B25/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by Df(1)sd72b/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by Df(2L)H20/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by Df(2L)TW137/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by Df(2L)TW50/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by Df(2L)cact-255rv64/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by Df(2R)CX1/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by Df(2R)P34/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by Df(2R)vg-C/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by Df(3R)M-Kx1/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by Df(3R)T-32/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by Df(1)C128/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by Df(3R)e-N19/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by Df(3R)e-R1/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by RasGAP1^B2

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by In(2LR)DTD16^LDTD42^R/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by Mi-2^S005504/Mi-2[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by Mi-2^S147412/Mi-2[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by Pp1-87B[+]/Pp1-87B^j6E7

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by Sin3A[+]/Sin3A⁰⁸²⁶⁹

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by Sin3A^ex4

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by bon^S048706/bon[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by Df(1)KA14/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by crb^j1B5/crb[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by hh²

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by hh[+]/hh^rJ413

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by l(3)S000710[+]/l(3)S000710^S000710

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by l(3)S016805[+]/l(3)S016805^S016805

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by l(3)S023549^S023549/l(3)S023549[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by l(3)S023549^S090101/l(3)S023549[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by l(3)S023708[+]/l(3)S023708^S023708

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by l(3)S024329^S024329/l(3)S024329[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by l(3)S024833[+]/l(3)S024833^S024833

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by Df(1)RA2/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by l(3)S046604^S046604/l(3)S046604[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by l(3)S066607[+]/l(3)S066607^S066607

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by l(3)S068808^S068808/l(3)S068808[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by l(3)S133117[+]/l(3)S133117^S133117

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by l(3)j2D5^j2D5/l(3)j2D5[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by l(3)j4B9^j4B9/l(3)j4B9[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by msn[+]/msn^j1E2

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by neur[+]/neur^j6B12

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by scrib[+]/scrib^j7B3

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, enhanceable by Df(1)lz-90b24/+

(Read et al., 2005)

NOT Enhanced by

Statement

Reference

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by Mi-2^S047526/Mi-2[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by Pp1-87B¹

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by S^k09530

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by crb^11A22

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by drk^k02401

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by drk^k13809

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by dsh³

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by dsh⁶

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by l(3)S000718[+]/l(3)S000718^S000718

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by l(3)S001405^S001405/l(3)S001405[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by l(3)S003704^S003704/l(3)S003704[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by l(3)S009515[+]/l(3)S009515^S009515

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by l(3)S012805^S012805/l(3)S012805[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by l(3)S019203^S141715/l(3)S019203[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by l(3)S026238^S026238/l(3)S026238[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by l(3)S026421^S026421/l(3)S026421[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by l(3)S056113[+]/l(3)S056113^S056113

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by l(3)S057101[+]/l(3)S057101^S057101

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by l(3)S081003^S145911/l(3)S081003[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by l(3)S090114[+]/l(3)S090114^S090114

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by l(3)S092708[+]/l(3)S092708^S092708

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by l(3)S135703^S135703/l(3)S135703[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by l(3)S142909^S142909/l(3)S142909[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by neur¹¹

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by px[+]/px^k08316

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by stg^S024503/stg[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by tws^S049902/tws[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by Csk^j1D8/Csk[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by CycA^S054513/CycA[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by Df(2R)AA21/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by Df(2R)Pu-D17/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by Df(2R)ST1/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-enhanceable by Df(3L)ZN47/+

(Read et al., 2005)

Suppressed by

Statement

Reference

Ret^MEN2A.GMR has eye phenotype, suppressible | partially by Fak^UAS.Tag:HA/Scer\GAL4^GMR.PU

(Macagno et al., 2014)

Ret^MEN2A.GMR has retina phenotype, suppressible | partially by Fak^UAS.Tag:HA/Scer\GAL4^GMR.PU

(Macagno et al., 2014)

Ret^MEN2A.GMR has cone cell | increased number | pupal stage phenotype, suppressible | partially by Fak^UAS.Tag:HA/Scer\GAL4^GMR.PU

(Macagno et al., 2014)

Ret^MEN2A.GMR has eye | adult stage phenotype, suppressible by DJ-1alpha[+]/DJ-1α^Δ72, dj-1β^Δ93/dj-1β^Δ93

(Aron et al., 2010)

Ret^MEN2A.GMR has eye phenotype, suppressible by Ras85D⁰⁶⁶⁷⁷

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by S^IIN

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by S[+]/S^k09538a

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by Src42A^k10108

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by Src64B^PI

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by bsk¹

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by bsk²

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by crb⁰⁷²⁰⁷

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by drk¹⁰⁶²⁶

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by ebi[+]/ebi^k16213

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by kis[+]/kis^k10237

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by ksr^S-627

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by ksr^j5E2

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by l(3)06803[+]/l(3)06803⁰⁶⁸⁰³

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by l(3)06906[+]/l(3)06906⁰⁶⁹⁰⁶

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by l(3)S023901[+]/l(3)S023901^S023901

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by l(3)j5B6^j5B6/l(3)j5B6[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by neur^A101

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by scrib¹

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by scrib⁶⁷³

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by spi¹

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by spi^s3547

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by Df(2L)TW161/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by Df(2L)al/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by Df(2L)net-PMF/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by +/Df(2R)59AD

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by Df(2R)X58-12/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by Df(3L)Pc-2q/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by Df(3R)Antp17/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by Df(3R)Cha7/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by Df(3R)DG2/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by +/Df(3R)Dl-BX12

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by Df(3R)Hu/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by Df(3R)ME15/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by Df(3R)by10/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by Dl^9P

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by Dl^S049520/Dl[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by Jra^IA109

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, suppressible by Pp1-87B²

(Read et al., 2005)

NOT suppressed by

Statement

Reference

Ret^MEN2A.GMR has eye phenotype, non-suppressible by Csk^j1D8/Csk[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by Df(3L)ZN47/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by Mi-2^S047526/Mi-2[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by Pp1-87B¹

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by S^k09530

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by crb^11A22

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by drk^k02401

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by drk^k13809

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by dsh³

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by dsh⁶

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by l(3)S000718[+]/l(3)S000718^S000718

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by CycA^S054513/CycA[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by l(3)S001405^S001405/l(3)S001405[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by l(3)S003704^S003704/l(3)S003704[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by l(3)S009515[+]/l(3)S009515^S009515

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by l(3)S012805^S012805/l(3)S012805[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by l(3)S019203^S141715/l(3)S019203[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by l(3)S026238^S026238/l(3)S026238[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by l(3)S026421^S026421/l(3)S026421[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by l(3)S056113[+]/l(3)S056113^S056113

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by l(3)S057101[+]/l(3)S057101^S057101

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by l(3)S081003^S145911/l(3)S081003[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by Df(2R)AA21/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by l(3)S090114[+]/l(3)S090114^S090114

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by l(3)S092708[+]/l(3)S092708^S092708

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by l(3)S135703^S135703/l(3)S135703[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by l(3)S142909^S142909/l(3)S142909[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by neur¹¹

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by px[+]/px^k08316

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by stg^S024503/stg[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by tws^S049902/tws[+]

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by Df(2R)Pu-D17/+

(Read et al., 2005)

Ret^MEN2A.GMR has eye phenotype, non-suppressible by Df(2R)ST1/+

(Read et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Fak^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU partially suppresses the small eye size induced by expression of one copy of Ret^MEN2A.GMR.

Expression of Fak^ΔN.Scer\UAS under the control of Scer\GAL4^GMR.PU does not suppress the small eye size induced by expression of one copy of Ret^MEN2A.GMR.

Expression of Fak^{Y430F.Scer\UAS} under the control of Scer\GAL4^GMR.PU partially suppresses the small eye size induced by expression of one copy of Ret^MEN2A.GMR.

Expression of Fak^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU partially suppresses the eye size defect and ectopic cone cell phenotype induced by expression of two copies of Ret^MEN2A.GMR, resulting in the reappearance of normal ommatidial cores and surrounding interommatidial cells in pupal retinas.

(Macagno et al., 2014)

DJ-1α^Δ72/+ dj-1β^Δ93/dj-1β^Δ93 significantly suppresses the small rough eye phenotype in Ret^MEN2A.GMR flies.

(Aron et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Ret^MEN2A.GMR

Name Synonyms

Secondary FlyBase IDs

References (5)

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