FlyBase Allele Report: Dmel\GstS1[UASp.cWa]

General Information

Symbol

Dmel\GstS1^UASp.cWa

Species

D. melanogaster

Name

FlyBase ID

FBal0190044

Feature type

allele

Associated gene

Dmel\GstS1

Associated Insertion(s)

Carried in Construct

P{UASp-GstS1}

Key Links

Transgenic product class

cDNA

(Whitworth et al., 2005)

wild_type

(Whitworth et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Whitworth et al., 2005)

wild_type

(Whitworth et al., 2005)

Mutagen

in vitro construct

(Whitworth et al., 2005)

Progenitor genotype

Carried in construct

P{UASp-GstS1}

Cytology

Description

UASp regulatory sequences drive expression of GstS1 coding sequences derived from LD21131.

(Whitworth et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

GstS1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by park^Z472

(Whitworth et al., 2005)

modeled by Hsap\SNCA^UAS.cTa

(Trinh et al., 2008)

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Arctic.UAS.Tag:SS(nec)}

(Rival et al., 2009)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of GstS1^UASp.cWa under the control of Scer\GAL4^VGlut-OK371 does not affect mitochondrial number or length in axons of adult neurons, compared to controls.

(Smith et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^VGlut1-OK371/GstS1^UASp.cWa is a suppressor of abnormal neuroanatomy | somatic clone | adult stage phenotype of gfzf⁵⁴¹

(Smith et al., 2019)

GstS1^UASp.cWa, Scer\GAL4^elav-C155 is a suppressor of abnormal locomotor behavior phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155

(Rival et al., 2009)

GstS1^UASp.cWa, Scer\GAL4^elav-C155 is a suppressor of short lived phenotype of Hsap\APP^{Arctic.UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155

(Rival et al., 2009)

GstS1^UASp.cWa, Scer\GAL4^ple.PF is a suppressor of abnormal neuroanatomy phenotype of Hsap\SNCA^UAS.cTa, Scer\GAL4^ple.PF

(Trinh et al., 2008)

Scer\GAL4^ple.PF/GstS1^UASp.cWa is a suppressor of abnormal neuroanatomy phenotype of park²⁵

(Whitworth et al., 2005)

Scer\GAL4^how-24B/GstS1^UASp.cWa is a suppressor of abnormal locomotor behavior | adult stage phenotype of park^Z3678

(Whitworth et al., 2005)

Scer\GAL4^how-24B/GstS1^UASp.cWa is a suppressor of abnormal locomotor behavior | adult stage phenotype of park^Z472

(Whitworth et al., 2005)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^VGlut1-OK371/GstS1^UASp.cWa is a suppressor of mitochondrion | somatic clone | adult stage phenotype of gfzf⁵⁴¹

(Smith et al., 2019)

Scer\GAL4^VGlut1-OK371/GstS1^UASp.cWa is a suppressor of axon | somatic clone | adult stage phenotype of gfzf⁵⁴¹

(Smith et al., 2019)

GstS1^UASp.cWa, Scer\GAL4^ple.PF is a suppressor of dopaminergic neuron phenotype of Hsap\SNCA^UAS.cTa, Scer\GAL4^ple.PF

(Trinh et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Overexpression of GstS1^{Scer\UAS.P\T.cWa}, only in the dopaminergic (DA) neurons, through the regulation of Scer\GAL4^ple.PF results in significant attenuation of the loss of DA neurons in 20-day old park²⁵ mutants. Expression of GstS1^{Scer\UAS.P\T.cWa} in the mesoderm, under the regulation of Scer\GAL4^how-24B is sufficient to restore the climbing ability of park^Z472 and park^Z3678 mutants.

(Whitworth et al., 2005)

Xenogenetic Interactions

Statement

Reference

Overexpression of GstS1^{Scer\UAS.P\T.cWa} partially suppresses the decreased survival phenotype of flies expressing Hsap\APP^{Arctic.Scer\UAS.T:nec} under the control of Scer\GAL4^elav-C155.

(Rival et al., 2009)

Co-expression of GstS1^{Scer\UAS.P\T.cWa} fully suppresses the neuronal loss observed in 2-day old flies expressing two copies of Hsap\SNCA^Scer\UAS.cTa under the control of two copies of Scer\GAL4^ple.PF.

(Trinh et al., 2008)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

95250

P{UASp-GstS1}1, w^*

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

GstS1^{Scer\UAS.P\T.cWa}

GstS1^UASp.cWa

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

Open Close