Allele Dmel\fru^Δtra

General Information
Symbol	Dmel\fru^Δtra	Species	D. melanogaster
Name		FlyBase ID	FBal0190085
Feature type	allele	Associated gene	Dmel\fru

Allele class
Mutagen	FLPase
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	FLPase (Demir and Dickson, 2005)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	fru^X-3'half (Demir and Dickson, 2005) fru^Δtra-5'half (Demir and Dickson, 2005)
Nature of the lesion	Statement Reference Scer\FLP1, Scer\FRT mediated recombination between fru^Δtra-5'half and fru^X-3'half has produced a fru gene lacking the 3' 261bp of the S-exon, sequence that includes the tra protein binding sites of this exon. No marker genes or vector sequence remain apart from an Scer\FRT site about 0.6 Kb 3' of the mutated S-exon. (Demir and Dickson, 2005)
Cytology
Phenotypic Data
Phenotypic Class
	female semi-fertile (with fru^4-40) (Demir and Dickson, 2005)
Phenotype Manifest In
	antennal lobe glomerulus DA1 (Stockinger et al., 2005) antennal lobe glomerulus VA1 (Stockinger et al., 2005) antennal lobe glomerulus VL2 (Stockinger et al., 2005) male abdominal 5 muscle \| ectopic \| female (with fru^4-40) (Demir and Dickson, 2005)
Detailed Description
	Statement Reference XX fru[Δtra]/+ animals do not show midline crossing by foreleg gustatory receptor neuron (GRN) axons (similar to XX wild-type control females). (Mellert et al., 2010) The normally male specific 'muscle of lawrence' is ectopically present in fru^Δtra/fru^4-40 females. fru^Δtra/fru^4-40 males exhibit normal levels of courtship behaviour towards females and show a small but significant competitive advantage over wild-type males in competition for copulation with a wild-type virgin female. This may be mainly due to a significant decrease in courtship latency seen in these males. fru^Δtra/fru^4-40 do not show any increase in courtship of other males compared to wild-type and do not form into mating chains. Less than 25% of fru^Δtra/fru^4-40 females are fertile. In mating assays in which a single virgin fru^Δtra/fru^4-40 female is paired with a wild-type male, less than 16% of these females copulate. fru^Δtra/fru^4-40 females court wild-type females, with courtship indices over 40% in single-pair assays. They also form courtship chains with other fru^Δtra/fru^4-40females (chaining indices >40%). These females perform all steps in the male courtship ritual apart from copulation, which is anatomically impossible, and abdominal bending in attempt to copulate, which may be inhibited by the much larger abdomen of females. However, the proportion of time spent in different parts of the courtship ritual differs form control (fru^C/fru^4-40) males: they spend significantly more time tapping and less time licking, overall courting time is reduced but initiation of courtship is just as rapid. Unlike control females, these females also court males. Courtship of males by fru^Δtra/fru^4-40 females is significantly enhanced if the males are tra^Scer\UAS.cFa; Scer\GAL4^oeC. (Demir and Dickson, 2005) The sexual dimorphism of the volumes of the DA1, VA1v and VL2a antennal glomeruli is eliminated in fru^Δtra mutant animals. (Stockinger et al., 2005)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference fru[+]/fru^Δtra is a suppressor of courtship behavior defective \| male phenotype of Scer\GAL4^elav.PLu, tra^Scer\UAS.cFa (Demir and Dickson, 2005)
Other
Statement Reference dsx¹, fru^Δtra has neuroanatomy defective \| female \| adult stage phenotype (Mellert et al., 2010)
Phenotype Manifest In
Other
Statement Reference dsx¹, fru^Δtra has prothoracic leg taste bristle chemosensory neuron \| female phenotype (Mellert et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference XX dsx[1] fru[Δtra]/dsx[1] animals have contralateral foreleg gustatory receptor neuron (GRN) axons in most cases. These XX animals have on average, less midline crossings than their XY dsx[1] fru[Δtra]/dsx[1] siblings. (Mellert et al., 2010) The reduction in courtship behaviour seen in tra^Scer\UAS.cFa; Scer\GAL4^elav.PLu males is suppressed by fru^Δtra/+. (Demir and Dickson, 2005)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	fru^Δtra (Mellert et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Mellert et al., 2010, Development 137(2): 323--332 Midline crossing by gustatory receptor neuron axons is regulated by fruitless, doublesex and the Roundabout receptors. [FBrf0209580] Demir and Dickson, 2005, Cell 121(5): 785--794 fruitless splicing specifies male courtship behavior in Drosophila. [FBrf0187223] Stockinger et al., 2005, Cell 121(5): 795--807 Neural circuitry that governs Drosophila male courtship behavior. [FBrf0187238]
Supplementary material	Demir and Dickson, 2005, Cell 121(5): [title not yet available] [FBrf0191487]
Abstract	Tirian and Dickson, 2006, A. Dros. Res. Conf. 47: 660B Dissecting the role of fruitless in male sexual behavior. [FBrf0189115]

Allele Dmel\fruΔtra

Allele Dmel\fru^Δtra