FB2025_02 , released April 17, 2025
Allele: Dmel\Socs36ESH2.UASp
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General Information
Symbol
Dmel\Socs36ESH2.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0190104
Feature type
allele
Associated gene
Dmel\Socs36E
Associated Insertion(s)
Carried in Construct
P{UASp-Socs36E.SH2}
Also Known As
UAS-SOCS-SH2*, UAS-Socs36E-SH2*
Key Links
Transgenic product class
missense_variant
(Callus and Mathey-Prevot, 2002)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Callus and Mathey-Prevot, 2002)
Mutagen
in vitro construct
(Silver et al., 2005, Callus and Mathey-Prevot, 2002)
Progenitor genotype
Socs36EUASp.cCa
(Callus and Mathey-Prevot, 2002)
Carried in construct
P{UASp-Socs36E.SH2}
Cytology
Description

Amino acid replacement R500L. This mutation prevents the SH2 domain of the protein product from binding to phosphorylated tyrosine regions.

(Callus and Mathey-Prevot, 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
Socs36E
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Socs36ESH2.Scer\UAS.P\T under the control of Scer\GAL4Mef2.247.Switch specifically during the adult stage (in the presence of RU486) has no effect on long term memory.

      (Copf et al., 2011)

      Unlike expression of a wild-type Socs36E transgene, expression of Socs36ESH2.Scer\UAS.P\T under the control of Scer\GAL4c306, fails to disrupt border cell migration.

      (Silver et al., 2005)

      Unlike expression of a wild-type Socs36E transgene, expression of Socs36ESH2.Scer\UAS.P\T, driven by Scer\GAL4ap-md544, fails to produce an outstretched wing phenotype. Expression of Socs36ESH2.Scer\UAS.P\T under the control of Scer\GAL4en-e16E causes a strong gradient in eye pigmentation, the same phenotype that occurs when wild-type Socs36E is overexpressed. However, the anterior cross vein loss and humeral outgrowth phenotypes produced by Scer\GAL4en-e16E-driven expression of the wild-type transgene are not seen when the Socs36ESH2.Scer\UAS.P\T transgene is expressed.

      (Callus and Mathey-Prevot, 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      Socs36ESH2.UASp/Scer\GAL4hs.2sev is a non-suppressor of visible phenotype of Scer\GAL4hs.2sev, sevS11.Tag:MYC

      (Almudi et al., 2009)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Socs36ESH2.Scer\UAS.P\T does not suppress the rough eye or extra R7 photoreceptor cell phenotype caused by expression of sevS11.T:Hsap\MYC under the control of Scer\GAL4hs.2sev.

      (Almudi et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Socs36ESH2.Scer\UAS.P\T
      Socs36ESH2.UASp
      Name Synonyms
      Secondary FlyBase IDs
        References (6)