Allele Hsap\HTT^{D10sFv.Scer\UAS.T:Ivir\HA1}

General Information
Symbol	Hsap\HTT^{D10sFv.Scer\UAS.T:Ivir\HA1}	Species	H. sapiens
Name		FlyBase ID	FBal0190127
Feature type	allele	Associated gene	Hsap\HTT

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Wolfgang et al., 2005) in vitro construct - regulatory fusion (Wolfgang et al., 2005)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Scer\UAS regulatory sequences drive expression of the N-terminal C4 domain of Hsap\HD tagged with T:Ivir\HA1. (Wolfgang et al., 2005)
Carried in construct	P{UAS-HTT.D10.HA} (Wolfgang et al., 2005)
Tagged with	T:Ivir\HA1 (Wolfgang et al., 2005)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	photoreceptor cell, with Hsap\HTT^{Q93.ex1p.Scer\UAS}, Scer\GAL4^elav-C155 (Wolfgang et al., 2005) rhabdomere, with Hsap\HTT^{Q93.ex1p.Scer\UAS}, Scer\GAL4^elav-C155 (Wolfgang et al., 2005)
Detailed Description
	Statement Reference Co-expression of Hsap\HD^{D10sFv.Scer\UAS.T:Ivir\HA1} with Hsap\HD^{Q93.ex1p.Scer\UAS}, under the control of Scer\GAL4^elav-C155 does not rescue the survival rate of Hsap\HD^{Q93.ex1p.Scer\UAS} flies. Co-expression of Hsap\HD^{D10sFv.Scer\UAS.T:Ivir\HA1} with Hsap\HD^{Q93.ex1p.Scer\UAS}, under the control of Scer\GAL4^elav-C155 generates a modest reduction in mean, median, and maximum survival time which is not considered significant. Aggregate density in the cell bodies of optic lobe neurons in Hsap\HD^{Q93.ex1p.Scer\UAS} flies is unaffected when Hsap\HD^{D10sFv.Scer\UAS.T:Ivir\HA1} is co-expressed. The percentage of ommatidia that contain seven rhabdomeres, indicating no neurodegeneration in Hsap\HD^{Q93.ex1p.Scer\UAS} flies expressing the control Hsap\HD^{D10sFv.Scer\UAS.T:Ivir\HA1} (47%) is similar to in flies expressing Hsap\HD^{Q93.ex1p.Scer\UAS} alone (49%). In flies expressing Hsap\HD^{Q93.ex1p.Scer\UAS} and the control Hsap\HD^{D10sFv.Scer\UAS.T:Ivir\HA1} (under the regulation of Scer\GAL4^elav-C155) as few as three ommatidia are observed. 6% of Hsap\HD^{Q93.ex1p.Scer\UAS}, Hsap\HD^{D10sFv.Scer\UAS.T:Ivir\HA1} (both under the control of Scer\GAL4^elav-C155) ommatidia contain seven photoreceptors. (Wolfgang et al., 2005)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to rescue	Scer\GAL4^elav-C155/Hsap\HTT^{D10sFv.Scer\UAS.T:Ivir\HA1} fails to rescue Hsap\HTT^{Q93.ex1p.Scer\UAS} (Wolfgang et al., 2005)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Hsap\HD^{D10sFv.Scer\UAS.T:Ivir\HA1} Hsap\HTT^{D10sFv.Scer\UAS.T:Ivir\HA1}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Wolfgang et al., 2005, Proc. Natl. Acad. Sci. U.S.A. 102(32): 11563--11568 Suppression of Huntington's disease pathology in Drosophila by human single-chain Fv antibodies. [FBrf0188282]

Allele Hsap\HTTD10sFv.Scer\UAS.T:Ivir\HA1

Allele Hsap\HTT^{D10sFv.Scer\UAS.T:Ivir\HA1}