Allele Dmel\Atx-1^Scer\UAS.cTa

General Information
Symbol	Dmel\Atx-1^Scer\UAS.cTa	Species	D. melanogaster
Name		FlyBase ID	FBal0190159
Feature type	allele	Associated gene	Dmel\Atx-1

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Tsuda et al., 2005)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Scer\UAS regulatory sequences drive expression of Atx-1 coding sequences. (Tsuda et al., 2005)
Carried in construct	P{UAS-Atx-1.T} (Tsuda et al., 2005)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	eye, with Scer\GAL4^ninaE.PT (Tsuda et al., 2005) eye photoreceptor cell, with Scer\GAL4^ninaE.PT (Tsuda et al., 2005) interommatidial bristle, with Scer\GAL4^GMR.PF (Tsuda et al., 2005) mesothoracic bristle, with Scer\GAL4^sca-109-68 (Tsuda et al., 2005) metathoracic bristle, with Scer\GAL4^sca-109-68 (Tsuda et al., 2005) ommatidium, with Scer\GAL4^GMR.PF (Tsuda et al., 2005) wing, with Scer\GAL4^bbg-C96 (Tsuda et al., 2005) wing, with Scer\GAL4^C5 (Tsuda et al., 2005) wing margin bristle, with Scer\GAL4^bbg-C96 (Tsuda et al., 2005) wing vein \| ectopic, with Scer\GAL4^GMR.PF (Tsuda et al., 2005) wing vein \| heat sensitive, with Scer\GAL4^C5 (Tsuda et al., 2005)
Detailed Description
	Statement Reference Overexpression of Atx-1^Scer\UAS.cTa, under the control of Scer\GAL4^ninaE.PT results in neurodegeneration in the eye. At 2 days after eclosion, no obvious morphological changes in the photoreceptor cells are observed. At 28 days, many large holes and a loss of cell integrity is observed. On average, five or six photoreceptor cells remain out of the eight found in normal eyes. Overexpression of Atx-1^Scer\UAS.cTa, under the control of Scer\GAL4^GMR.PF induces eye abnormalities. The external structures of the eyes exhibit disorganised ommatidia and a loss of interommatidial bristles. They also exhibit a loss of rhabdomeres and tissue integrity. Overexpression of Atx-1^Scer\UAS.cTa, under the control of Scer\GAL4^GMR.PF also generates extra wing-vein tissue. Overexpression of Atx-1^Scer\UAS.cTa, under the control of Scer\GAL4^C5 in the wing pouch at 27^oC results in several vein abnormalities. Overexpression of Atx-1^Scer\UAS.cTa, under the control of Scer\GAL4^C96 in the wing margin causes bristle abnormalities including patterning defects and bristle loss. Overexpression of Atx-1^Scer\UAS.cTa in the sensory organ precursor cells under the control of Scer\GAL4^sca-109-68 causes a loss of thoracic bristles. (Tsuda et al., 2005)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement Reference Atx-1^Scer\UAS.cTa, Scer\GAL4^sca-109-68 has mesothoracic bristle phenotype, suppressible by sens^Scer\UAS.cNa, Scer\GAL4^sca-109-68 (Tsuda et al., 2005) Atx-1^Scer\UAS.cTa, Scer\GAL4^sca-109-68 has metathoracic bristle phenotype, suppressible by sens^Scer\UAS.cNa, Scer\GAL4^sca-109-68 (Tsuda et al., 2005)
Additional Comments
Genetic Interactions
Statement Reference Coexpression of sens^Scer\UAS.cNa with Atx-1^Scer\UAS.cTa (both under the control of Scer\GAL4^sca-109-68) abolishes the loss of thoracic bristles phenotype of Atx-1^Scer\UAS.cTa overexpression (Tsuda et al., 2005)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	39741 y¹ w^*; P{UAS-Atx-1.T}MBR/TM6B, Tb¹
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Atx-1^Scer\UAS.cTa
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Tsuda et al., 2005, Cell 122(4): 633--644 The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. [FBrf0187241]

Allele Dmel\Atx-1Scer\UAS.cTa

Allele Dmel\Atx-1^Scer\UAS.cTa