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General Information
Symbol
Dmel\Atx-1UAS.cTa
Species
D. melanogaster
Name
FlyBase ID
FBal0190159
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-dAtx-1
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of Atx-1 coding sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Overexpression of Scer\GAL4GMR.PF>Atx-1Scer\UAS.cTa induces rhabdomere degeneration.

Overexpression of Atx-1Scer\UAS.cTa, under the control of Scer\GAL4ninaE.PT results in neurodegeneration in the eye. At 2 days after eclosion, no obvious morphological changes in the photoreceptor cells are observed. At 28 days, many large holes and a loss of cell integrity is observed. On average, five or six photoreceptor cells remain out of the eight found in normal eyes. Overexpression of Atx-1Scer\UAS.cTa, under the control of Scer\GAL4GMR.PF induces eye abnormalities. The external structures of the eyes exhibit disorganised ommatidia and a loss of interommatidial bristles. They also exhibit a loss of rhabdomeres and tissue integrity. Overexpression of Atx-1Scer\UAS.cTa, under the control of Scer\GAL4GMR.PF also generates extra wing-vein tissue. Overexpression of Atx-1Scer\UAS.cTa, under the control of Scer\GAL4C5 in the wing pouch at 27oC results in several vein abnormalities. Overexpression of Atx-1Scer\UAS.cTa, under the control of Scer\GAL4C96 in the wing margin causes bristle abnormalities including patterning defects and bristle loss. Overexpression of Atx-1Scer\UAS.cTa in the sensory organ precursor cells under the control of Scer\GAL4sca-109-68 causes a loss of thoracic bristles.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of NmnatWR.Scer\UAS suppresses the rhabdomere degeneration phenotype induced by Scer\GAL4GMR.PF>Atx-1Scer\UAS.cTa.

Co-expression of NmnatScer\UAS.cZa suppresses the rhabdomere degeneration phenotype induced by Scer\GAL4GMR.PF>Atx-1Scer\UAS.cTa.

Coexpression of sensScer\UAS.cNa with Atx-1Scer\UAS.cTa (both under the control of Scer\GAL4sca-109-68) abolishes the loss of thoracic bristles phenotype of Atx-1Scer\UAS.cTa overexpression

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Atx-1Scer\UAS.cTa
Atx-1UAS.cTa
Name Synonyms
Secondary FlyBase IDs
    References (2)