Allele Dmel\PGRP-SC1a^Z2-4761

General Information
Symbol	Dmel\PGRP-SC1a^Z2-4761	Species	D. melanogaster
Name		FlyBase ID	FBal0190196
Feature type	allele	Associated gene	Dmel\PGRP-SC1a

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Garver et al., 2006)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	immune response defective \| adult stage (Garver et al., 2006) viable (Garver et al., 2006)
Phenotype Manifest In

Detailed Description
	Statement Reference PGRP-SC1a^Z2-4761 mutant adults phagocytose E.coli and B.subtilis normally, but phagocytosis of dead S.aureus particles is reduced. Survival of these flies following E.coli infection is as wild-type, but lethality occurs much sooner following S.aureus infection than in wild-type and no accumulation of live S.aureus in phagosomes can be seen 24 hours after infection. : (Garver et al., 2006)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	PGRP-SC1a^Z2-4761 is rescued by Scer\GAL4^T155/PGRP-SC1a^Scer\UAS.cGa (Garver et al., 2006)
Partially rescued by	PGRP-SC1a^Z2-4761 is partially rescued by Scer\GAL4^T155/PGRP-SC1a^m.Scer\UAS (Garver et al., 2006)
Comments	Phagocytosis of dead S.aureus particles in PGRP-SC1a^Z2-4761 adults is rescued by PGRP-SC1a^Scer\UAS.cGa; Scer\GAL4^T155 & partially rescued by PGRP-SC1a^m.Scer\UAS; Scer\GAL4^T155. The rate of lethality in these flies due to infection with live S.aureus is slowed and the accumulation of live S.aureus into phagosomes is rescued by PGRP-SC1a^Scer\UAS.cGa; Scer\GAL4^T155 and by PGRP-SC1a^m.Scer\UAS; Scer\GAL4^T155 in the presence, but not the absence, of free S.aureus peptidoglycan. GA24. Gain of function data -- structured ^SoftCV (Garver et al., 2006)
Stocks ( 0 )

Notes on Origin
Discoverer
	Associated with: PGRP-SC1b^Z2-4761 (Garver et al., 2006)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	PGRP-SC1a^Z2-4761 picky^Z4761 (Garver et al., 2006) picky eater^Z2-4761 (Garver et al., 2006)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Garver et al., 2006, Proc. Natl. Acad. Sci. U.S.A. 103(3): 660--665 The peptidoglycan recognition protein PGRP-SC1a is essential for Toll signaling and phagocytosis of Staphylococcus aureus in Drosophila. [FBrf0191436]

Allele Dmel\PGRP-SC1aZ2-4761

Allele Dmel\PGRP-SC1a^Z2-4761