Allele Dmel\Cp190²

General Information
Symbol	Dmel\Cp190²	Species	D. melanogaster
Name		FlyBase ID	FBal0190234
Feature type	allele	Associated gene	Dmel\Cp190

Allele class	loss of function allele
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	loss of function allele (Butcher et al., 2004)
Mutagen	ethyl methanesulfonate (Butcher et al., 2004)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| larval stage \| partially (with Cp190¹) (Butcher et al., 2004) lethal \| larval stage \| partially (with Df(3R)P280-NR27) (Butcher et al., 2004) lethal \| larval stage \| partially \| recessive (Butcher et al., 2004) lethal \| pharate adult stage (with Cp190¹) (Butcher et al., 2004) lethal \| pharate adult stage (with Df(3R)P280-NR27) (Butcher et al., 2004) lethal \| pharate adult stage \| recessive (Butcher et al., 2004)
Phenotype Manifest In
	cleavage nucleus (Chodagam et al., 2005)
Detailed Description
	Statement Reference Cp190² germ-line clone embryos have a severe axial-expansion defect; at nuclear cycle 7-8 the nuclei remain clustered toward the anterior of the embryo. (Chodagam et al., 2005) Cp190², Cp190²/Df(3R)P280-NR27 and Cp190¹/Cp190² mutants show some larval mortality, but approximately half the mutants survive until late pupal stages, dying as pharate adults. Cp190² larval brains show no obvious mitotic defects and the eyes, wings and cuticle of pharate adults appear normal, showing that tissue organization is not affected by a major defect in mitosis. Additionally, there are no observable meiotic defects in Cp190² larval testes. (Butcher et al., 2004)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement Reference Cp190² has cleavage nucleus phenotype, suppressible \| partially by sqh^E20.E21 (Chodagam et al., 2005)
NOT suppressed by
Statement Reference Cp190² has cleavage nucleus phenotype, non-suppressible by sqh^T:Avic\GFP (Chodagam et al., 2005)
Additional Comments
Genetic Interactions
Statement Reference Expression of one copy of the sqh^E20.E21 transgene partially restores axial expansion in Cp190² germ-line clone embryos. However, expression of one copy of the wild-type sqh^T:Avic\GFP transgene does not rescue this defect. (Chodagam et al., 2005)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	Cp190² is rescued by Cp190^Ubi-p63E.PB (Chodagam et al., 2005, Butcher et al., 2004) Df(3R)P280-NR27/Cp190² is rescued by Cp190^Ubi-p63E.PB (Butcher et al., 2004)
Partially rescued by	Cp190² is partially rescued by Cp190^ΔM.Ubi-p63E (Chodagam et al., 2005, Butcher et al., 2004)
Comments	Expression of the Cp190^ΔM.Ubi-p63E transgene fails to rescue the axial-expansion defect of Cp190² flies. (Chodagam et al., 2005) The Cp190^ΔM.Ubi-p63E transgene rescues the lethality of Cp190² mutants so that ~80% of flies survive to adulthood. However, these adults are unhealthy and only survive for a few days. (Butcher et al., 2004)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Cp190²
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Chodagam et al., 2005, Curr. Biol. 15(14): 1308--1313 The centrosomal protein CP190 regulates myosin function during early Drosophila development. [FBrf0187303] Butcher et al., 2004, J. Cell Sci. 117(7): 1191--1199 The Drosophila centrosome-associated protein CP190 is essential for viability but not for cell division. [FBrf0174805]

Allele Dmel\Cp1902

Allele Dmel\Cp190²