Allele Scer\GAL4^Tdc2.PC

General Information
Symbol	Scer\GAL4^Tdc2.PC	Species	S. cerevisiae
Name	Tdc2 promoter construct of Cole	FlyBase ID	FBal0190372
Feature type	allele	Associated gene	Scer\GAL4

Allele class
Mutagen	in vitro construct - coding region fusion
Recent Updates
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FB2013_03
FB2013_02	Controlled Vocabulary Terms small body
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Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Cole et al., 2005)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: A Tdc2 promoter (-3459 to +4530 relative to the coding start site) drives Scer\GAL4 expression. A Hsp70 3' poly(A) sequence flanks the Scer\GAL4 coding region. (Cole et al., 2005)
Carried in construct	P{Tdc2-GAL4.C} (Stavropoulos and Young, 2011, Koon et al., 2011, Keegan et al., 2011, Koon and Budnik, 2012, Yarali and Gerber, 2010, Cole et al., 2005, Schroll et al., 2006, Hardie et al., 2007, Kaplan et al., 2008, Dankert et al., 2009, Honjo and Furukubo-Tokunaga, 2009, Zhou et al., 2008, Vömel and Wegener, 2008, Boerner and Duch, 2010, Brembs et al., 2007, Sitaraman et al., 2010, Certel et al., 2010, Chiang et al., 2011, Han et al., 2011, Lee et al., 2009, Majumdar et al., 2012, Crocker et al., 2010, Hampel et al., 2011, Busch et al., 2009, Zhou et al., 2012, Kahsai and Winther, 2011, Pauls et al., 2010, Liu et al., 2012, Schneider et al., 2012, Chen et al., 2013)
Cytology
Phenotypic Data
Phenotypic Class
	behavior defective, with Hsap\KCNJ2^{Scer\UAS.T:Avic\GFP-EGFP} (Dankert et al., 2009) behavior defective, with tra^Scer\UAS.cFa (Dankert et al., 2009) behavior defective \| adult stage \| heat sensitive, with Bhal\NaChBac^Scer\UAS.cNa, Scer\GAL80^ts.αTub84B (Zhou et al., 2008) behavior defective \| heat sensitive, with shi^1.Scer\UAS (Zhou et al., 2008) chemical resistant, with Bacc^GD12572 (Chen et al., 2013) chemical resistant \| heat sensitive, with shi^1.Scer\UAS (Chen et al., 2013) chemosensitive behavior defective, with Hsap\KCNJ2^{Scer\UAS.T:Avic\GFP-EGFP} (Schneider et al., 2012) chemosensitive behavior defective \| adult stage, with Hsap\KCNJ2^{Scer\UAS.T:Avic\GFP-EGFP} (Hardie et al., 2007) courtship behavior defective, with tra^Scer\UAS.cFa (Dankert et al., 2009) courtship behavior defective \| male \| heat sensitive, with shi^1.Scer\UAS (Zhou et al., 2012) courtship behavior defective \| male \| heat sensitive, with TrpA1^Scer\UAS.cKa (Zhou et al., 2012) female sterile, with Hsap\KCNJ2^{Scer\UAS.T:Avic\GFP-EGFP} (Hardie et al., 2007) flight defective, with rpr^Scer\UAS.C (Brembs et al., 2007) learning defective \| heat sensitive, with shi^1.Scer\UAS (Honjo and Furukubo-Tokunaga, 2009) learning defective \| male \| heat sensitive, with shi^1.Scer\UAS (Zhou et al., 2012) learning defective \| male \| heat sensitive, with TrpA1^Scer\UAS.cKa (Zhou et al., 2012) locomotor behavior defective, with rpr^Scer\UAS.C (Brembs et al., 2007) locomotor behavior defective, with tra^Scer\UAS.cFa (Dankert et al., 2009) locomotor behavior defective \| adult stage, with Hsap\KCNJ2^{Scer\UAS.T:Avic\GFP-EGFP} (Hardie et al., 2007) mating defective, with fru^{dsRNA.M.Scer\UAS} (Certel et al., 2010) mating defective, with TrpA1^Scer\UAS.cKa (Certel et al., 2010) memory defective \| heat sensitive, with shi^1.Scer\UAS (Honjo and Furukubo-Tokunaga, 2009) neuroanatomy defective \| third instar larval stage, with Bper\ptxA^act.Scer\UAS (Koon and Budnik, 2012) neuroanatomy defective \| third instar larval stage, with dnc^Scer\UAS.cCa (Koon and Budnik, 2012) neuroanatomy defective \| third instar larval stage, with Gαo^GD8640 (Koon and Budnik, 2012) neuroanatomy defective \| third instar larval stage, with Gαo^KK109018 (Koon and Budnik, 2012) neuroanatomy defective \| third instar larval stage, with oa2^KK102153 (Koon and Budnik, 2012) sleep defective, with Bhal\NaChBac^{Scer\UAS.T:Avic\GFP-EGFP} (Crocker et al., 2010) sleep defective, with Bhal\NaChBac^{Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL80^αTub84B.PL (Crocker et al., 2010) sleep defective \| heat sensitive, with TrpA1^Scer\UAS.cKa (Liu et al., 2012) starvation stress response defective, with Octβ2R^GD2954 (Koon et al., 2011) starvation stress response defective, with Octβ2R^KK109808 (Koon et al., 2011) starvation stress response defective, with W^Scer\UAS.cZa (Koon et al., 2011) starvation stress response defective \| drug conditional, with CrebB^b.Scer\UAS (Koon et al., 2011) starvation stress response defective \| third instar larval stage, with Bper\ptxA^act.Scer\UAS (Koon and Budnik, 2012) starvation stress response defective \| third instar larval stage, with Gαo^KK109018 (Koon and Budnik, 2012)
Phenotype Manifest In
	embryonic/larval neuromuscular junction \| drug conditional, with CrebB^b.Scer\UAS (Koon et al., 2011) embryonic/larval neuromuscular junction \| first instar larval stage \| heat sensitive, with Hsap\KCNJ2^{Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL80^ts.αTub84B (Koon et al., 2011) embryonic/larval neuromuscular junction \| third instar larval stage, with Bper\ptxA^act.Scer\UAS (Koon and Budnik, 2012) embryonic/larval neuromuscular junction \| third instar larval stage, with dnc^Scer\UAS.cCa (Koon and Budnik, 2012) embryonic/larval neuromuscular junction \| third instar larval stage, with Gαo^GD8640 (Koon and Budnik, 2012) embryonic/larval neuromuscular junction \| third instar larval stage, with Gαo^KK109018 (Koon and Budnik, 2012) embryonic/larval neuromuscular junction \| third instar larval stage, with Hsap\KCNJ2^{Scer\UAS.T:Avic\GFP-EGFP} (Koon et al., 2011) embryonic/larval neuromuscular junction \| third instar larval stage, with oa2^KK102153 (Koon and Budnik, 2012) embryonic/larval neuromuscular junction \| third instar larval stage, with Octβ2R^GD2954 (Koon et al., 2011) embryonic/larval neuromuscular junction \| third instar larval stage, with Octβ2R^KK109808 (Koon et al., 2011) embryonic/larval neuromuscular junction \| third instar larval stage, with W^Scer\UAS.cZa (Koon et al., 2011) embryonic/larval neuromuscular junction \| third instar larval stage \| heat sensitive, with Scer\GAL80^ts.αTub84B, shi^1.Scer\UAS (Koon et al., 2011) multidendritic neuron, with Hsap\KCNJ2^{Scer\UAS.T:Avic\GFP-EGFP} (Koon et al., 2011) multidendritic neuron \| drug conditional, with CrebB^b.Scer\UAS (Koon et al., 2011) multidendritic neuron \| heat sensitive, with Hsap\KCNJ2^{Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL80^ts.αTub84B (Koon et al., 2011) multidendritic neuron \| heat sensitive, with Scer\GAL80^ts.αTub84B, shi^1.Scer\UAS (Koon et al., 2011) type I bouton, with Hsap\KCNJ2^{Scer\UAS.T:Avic\GFP-EGFP} (Koon et al., 2011) type I bouton \| third instar larval stage, with Octβ2R^GD2954 (Koon et al., 2011) type I bouton \| third instar larval stage, with Octβ2R^KK109808 (Koon et al., 2011) type I bouton \| third instar larval stage, with W^Scer\UAS.cZa (Koon et al., 2011) type II bouton, with Hsap\KCNJ2^{Scer\UAS.T:Avic\GFP-EGFP} (Koon et al., 2011) type II bouton \| first instar larval stage \| heat sensitive, with Hsap\KCNJ2^{Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL80^ts.αTub84B (Koon et al., 2011) type II bouton \| supernumerary \| third instar larval stage, with Gαo^GD8640 (Koon and Budnik, 2012) type II bouton \| supernumerary \| third instar larval stage, with Gαo^KK109018 (Koon and Budnik, 2012) type II bouton \| supernumerary \| third instar larval stage, with oa2^KK102153 (Koon and Budnik, 2012) type II bouton \| third instar larval stage, with Bper\ptxA^act.Scer\UAS (Koon and Budnik, 2012) type II bouton \| third instar larval stage, with dnc^Scer\UAS.cCa (Koon and Budnik, 2012) type II bouton \| third instar larval stage, with Octβ2R^GD2954 (Koon et al., 2011) type II bouton \| third instar larval stage, with Octβ2R^KK109808 (Koon et al., 2011) type II bouton \| third instar larval stage, with W^Scer\UAS.cZa (Koon et al., 2011) type II bouton \| third instar larval stage \| heat sensitive, with Scer\GAL80^ts.αTub84B, shi^1.Scer\UAS (Koon et al., 2011)
Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Scer\GAL4^Tdc2.PC, Tbh^nM18 has mating defective phenotype, enhanceable by Tbh^nM18 (Certel et al., 2010)
Suppressor of
Statement Reference Scer\GAL4^Tdc2.PC/Tdc1^Scer\UAS.cCa is a suppressor of chemosensitive behavior defective \| semidominant \| adult stage phenotype of Tdc2^RO54 (Hardie et al., 2007) Scer\GAL4^Tdc2.PC/Tdc1^Scer\UAS.cCa is a suppressor of female sterile \| recessive phenotype of Tdc2^RO54 (Cole et al., 2005)
Phenotype Manifest In
NOT Suppressor of
Statement Reference Scer\GAL4^Tdc2.PC/Tdc1^Scer\UAS.cCa is a non-suppressor of adult brain phenotype of Tdc2^RO54 (Cole et al., 2005)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	Scer\GAL4^Tdc2.PC/dnc^Scer\UAS.cCa rescues dnc^M14 (Koon et al., 2011) Scer\GAL4^Tdc2.PC/dnc^Scer\UAS.cCa rescues dnc^ML (Koon et al., 2011) Scer\GAL4^Tdc2.PC/dnc^Scer\UAS.cCa rescues dnc^ML/dnc^M14 (Koon et al., 2011) Scer\GAL4^Tdc2.PC/rut^Scer\UAS.cZa rescues rut²⁰⁸⁰ (Koon et al., 2011) Scer\GAL4^Tdc2.PC/Tbh^Scer\UAS.cSa rescues Tbh^nM18 (Schneider et al., 2012) Tbh^Scer\UAS.cMa, Scer\GAL4^Tdc2.PC, Scer\GAL80^Cha.PK rescues Tbh^nM18 (Zhou et al., 2008) Tbh^Scer\UAS.cMa/Scer\GAL4^Tdc2.PC rescues Tbh^nM18 (Zhou et al., 2008, Koon et al., 2011, Zhou et al., 2012)
Partially rescues	Scer\GAL4^Tdc2.PC/Tdc2^Scer\UAS.cCb partially rescues Tdc2^RO54 (Cole et al., 2005)
Fails to rescue	Scer\GAL4^Tdc2.PC, inc^f00285 fails to rescue inc^f00285 (Stavropoulos and Young, 2011) Scer\GAL4^Tdc2.PC, Tbh^Scer\UAS.cSa, Scer\GAL80^Cha.PK fails to rescue Tbh^nM18 (Schneider et al., 2012) Scer\GAL4^Tdc2.PC/Adar^{3.4.S.Scer\UAS} fails to rescue Adar^5G1 (Keegan et al., 2011) Scer\GAL4^Tdc2.PC/Ns3^{Scer\UAS.T:Avic\GFP-YFP.Venus} fails to rescue Ns3^G0431 (Kaplan et al., 2008) Scer\GAL4^Tdc2.PC/Tdc2^Scer\UAS.cCb fails to rescue Tdc2^RO54 (Hardie et al., 2007)
Comments
Stocks ( 1 )
Bloomington	9313 w^*; P{Tdc2-GAL4.C}2
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Scer\GAL4^Tdc2.PC
Name Synonym	Tdc2 promoter construct of Cole (Cole et al., 2005)
Secondary FlyBase IDs

References ( 31 )

Generate a list of	All references relating to this allele ( 31 )

List References by type	Research paper ( 30 ) Supplementary material ( 1 )
Recent research papers ( 14 )
	Chen et al., 2013, Neuropharmacology 67: 25--31 Mutations in Bacchus reveal a tyramine-dependent nuclear regulator for acute ethanol sensitivity in Drosophila. [FBrf0220671] Chen et al., 2012, Science 335(6069): 678--685 Visualizing long-term memory formation in two neurons of the Drosophila brain. [FBrf0217453] Koon and Budnik, 2012, J. Neurosci. 32(18): 6312--6322 Inhibitory control of synaptic and behavioral plasticity by octopaminergic signaling. [FBrf0218256] Liu et al., 2012, Curr. Biol. 22(22): 2114--2123 Two dopaminergic neurons signal to the dorsal fan-shaped body to promote wakefulness in Drosophila. [FBrf0220041] Majumdar et al., 2012, Cell 148(3): 515--529 Critical Role of Amyloid-like Oligomers of Drosophila Orb2 in the Persistence of Memory. [FBrf0217407] Schneider et al., 2012, PLoS ONE 7(12): e52007 Neuronal basis of innate olfactory attraction to ethanol in Drosophila. [FBrf0220349] Zhou et al., 2012, J. Neurosci. 32(41): 14281--14287 Molecular Genetic Analysis of Sexual Rejection: Roles of Octopamine and Its Receptor OAMB in Drosophila Courtship Conditioning. [FBrf0219612] Chiang et al., 2011, Curr. Biol. 21(1): 1--11 Three-Dimensional Reconstruction of Brain-wide Wiring Networks in Drosophila at Single-Cell Resolution. [FBrf0212704] Hampel et al., 2011, Nat. Methods 8(3): 253--259 Drosophila Brainbow: a recombinase-based fluorescence labeling technique to subdivide neural expression patterns. [FBrf0213136] Han et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(23): 9673--9678 Enhancer-driven membrane markers for analysis of nonautonomous mechanisms reveal neuron-glia interactions in Drosophila. [FBrf0213916] Kahsai and Winther, 2011, J. Comp. Neurol. 519(2): 290--315 Chemical neuroanatomy of the Drosophila central complex: distribution of multiple neuropeptides in relation to neurotransmitters. [FBrf0212649] Keegan et al., 2011, Nucleic Acids Res. 39(16): 7249--7262 Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects. [FBrf0215032] Koon et al., 2011, Nat. Neurosci. 14(2): 190--199 Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling. [FBrf0212895] Stavropoulos and Young, 2011, Neuron 72(6): 964--976 insomniac and Cullin-3 Regulate Sleep and Wakefulness in Drosophila. [FBrf0217043] Show all research papers ...

Allele Scer\GAL4Tdc2.PC

Allele Scer\GAL4^Tdc2.PC