|Feature type||allele||Associated gene||Dmel\EcR|
|Mutagen||in vitro construct - regulatory fusion, in vitro construct - amino acid replacement|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Carried in construct|
|Phenotype Manifest In|
Muscle expression of EcR[A-ΔC655.F645A.Scer\UAS] under the control of Scer\GAL4[Mhc.PW] produces a delay in synapse elimination due to post-synaptic disruption of EcR signaling. Expression of EcR[A-ΔC655.F645A.Scer\UAS] in presynaptic neurons (under the control of Scer\GAL4[OK6] does not delay synapse elimination. Expression of EcR[A-ΔC655.F645A.Scer\UAS] postsynaptically (under the control of Scer\GAL4[OK6]) in 9 hour APF pupae does not induce presynaptic dismantling such as synaptic vesicle aggregation, decreased bouton number, or enlarged bouton size, while post-synaptic dismantling occurs normally.
Specific overexpression of EcR[A-ΔC655.F645A.Scer\UAS] in the eye, under the control of Scer\GAL4[GMR.PF], disrupts differentiation of the ommatidia and eye patterning. This results in a decrease in pigment cells, collapse of the eye, and characteristic scarring. Inhibition of EcR function by the expression of EcR[A-ΔC655.F645A.Scer\UAS] under the control of Scer\GAL4[e22c] has no effect on wing size.
BrdU incorporation and the number of mitotic cells is reduced in clones in the wing disc expressing EcR[A-ΔC655.F645A.Scer\UAS] under the control of Scer\GAL4[Act5C.PP] compared to control clones.
Thoracic ventral neurosecretory cells that express EcRA-ΔC655.F645A.Scer\UAS under the control of Scer\GAL4Fmrf.PS are of normal size and larval morphology at the start of metamorphosis. However, these mutants show defective neuronal remodelling during metamorphosis. The axons show much lower levels of pruning compared to wild-type cells and show no filopodia during the pruning phase.
|Phenotype Manifest In|
EcRA-ΔC655.F645A.Scer\UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has ommatidium phenotype, suppressible by EcRA-ΔC655.F645A.Scer\UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
EcRA-ΔC655.F645A.Scer\UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has pigment cell phenotype, suppressible by EcRA-ΔC655.F645A.Scer\UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
EcRA-ΔC655.F645A.Scer\UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF is a suppressor of ommatidium phenotype of EcRA-ΔC655.F645A.Scer\UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
EcRA-ΔC655.F645A.Scer\UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF is a suppressor of pigment cell phenotype of EcRA-ΔC655.F645A.Scer\UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
Knock-down of LKR through LKR[IR.Scer\UAS] partially restores the pigmentation defect found in EcR[A-ΔC655.F645A.Scer\UAS] (Scer\GAL4[GMR.PF]) mutants and display a striking decrease of scarring compared to expression of EcR[A-ΔC655.F645A.Scer\UAS] (Scer\GAL4[GMR.PF]) alone. Expression of EcR[A-ΔC655.F645A.Scer\UAS] restores the small wing phenotype caused by LKR[IR.Scer\UAS].
|Complementation & Rescue Data|
|Stocks ( 1 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 1 )|
|Secondary FlyBase IDs|
|References ( 5 )|