FlyBase Allele Report: Dmel\tld[UAS.cHa]

General Information

Symbol

Dmel\tld^UAS.cHa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Hoffman

FlyBase ID

FBal0190693

Feature type

allele

Associated gene

Dmel\tld

Associated Insertion(s)

Carried in Construct

P{UAS-tld.H}

Also Known As

UAS-tld

Key Links

Transgenic product class

wild_type

(Serpe et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Serpe et al., 2005)

Mutagen

in vitro construct

(Serpe et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-tld.H}

Cytology

Description

UAS sequences drive expression of tld.

(Serpe et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

tld

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

posterior crossvein, with Scer\GAL4^A9

(Serpe et al., 2005)

posterior crossvein, with Scer\GAL4^da.G32

(Serpe et al., 2005)

posterior crossvein, with Scer\GAL4^en-e16E

(Serpe et al., 2005)

Detailed Description

Statement

Reference

Expression of tld^Scer\UAS.cHa in the wing, driven by Scer\GAL4^da.G32, often leads to expanded posterior crossvein material and the detachment of the posterior crossvein from L5. Expression of this transgene under the control of Scer\GAL4^A9 causes a detached posterior crossvein from L5 in 16% of wings. Overexpression driven by Scer\GAL4^en-e16E causes the widening or absence of the posterior crossvein.

(Serpe et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

tld^UAS.cHa/Scer\GAL4^elav.PLu is a non-suppressor of abnormal neuroanatomy phenotype of tok^K788/tok^D427

(Meyer and Aberle, 2006)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^A9, tld^UAS.cHa has posterior crossvein phenotype, enhanceable by Scer\GAL4^A9/tok^{UAS.cSa.Tag:HA}

(Serpe et al., 2005)

NOT Suppressor of

Statement

Reference

tld^UAS.cHa/Scer\GAL4^elav.PLu is a non-suppressor of embryonic/larval neuromuscular junction phenotype of tok^K788/tok^D427

(Meyer and Aberle, 2006)

Scer\GAL4^A9/tld^UAS.cHa is a non-suppressor of crossvein phenotype of tok^Δ2-41/tok^E1

(Serpe et al., 2005)

tld^UAS.cHa/Scer\GAL4^da.G32 is a non-suppressor of crossvein phenotype of tok^Δ2-41/tok^E1

(Serpe et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Co-overexpression of tld^Scer\UAS.cHa and tok^Scer\UAS.cSa, under the control of Scer\GAL4^A9, leads to an increased penetrance and severity of the posterior crossvein phenotype compared to expression of tld^Scer\UAS.cHa alone. Expression of tld^Scer\UAS.cHa under the control of Scer\GAL4^da.G32 or Scer\GAL4^A9 fails to rescue the posterior crossvein phenotype of tok^Δ2-41/tok^E1 mutants.

(Serpe et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

M. Hoffman

(Serpe et al., 2005)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

tld^Scer\UAS.cHa

tld^UAS.cHa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Hoffman

(Serpe et al., 2005)

Secondary FlyBase IDs

References (3)

Report Sections

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