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General Information
Symbol
Dmel\RbfΔ14
Species
D. melanogaster
Name
FlyBase ID
FBal0190925
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
rbf1Δ14
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Homozygous clones in the pupal eye (analysed at 42 hours after puparium formation) result in ommatidia with cone cell abnormalities and abnormal numbers of photoreceptor cells.

    Compared with wild-type controls, homozygous RbfΔ14 mutant cells in the eye disc show heightened sensitivity to apoptosis after treatment with ionising irradiation.

    Cells at the dorsal-ventral boundary of the late third instar wing disc are normally insensitive to irradiation induced apoptosis but become sensitive to it if they are part of RbfΔ14 homozygous somatic clones. (40Gy of γ rays; assayed after 4 hours at 25oC). There is also a general increase in cell death throughout these clones.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Enhancer of
    Statement
    Reference

    RbfΔ14/Rbf[+] is an enhancer of eye | somatic clone phenotype of Utx1

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Heterozygosity for RbfΔ14 strongly enhances the over-representation phenotype of Utx1 mosaic eyes: all mosaic eyes are now composed of almost 100% Utx1 tissue.

    Xenogenetic Interactions
    Statement
    Reference

    BacA\p35GMR.PH does not suppress the defects seen in homozygous RbfΔ14 clones in the pupal eye.

    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (4)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (7)