FB2025_01 , released February 20, 2025
Allele: Dmel\Socs36EΔSB.UASp
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General Information
Symbol
Dmel\Socs36EΔSB.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0190996
Feature type
allele
Associated gene
Dmel\Socs36E
Associated Insertion(s)
Carried in Construct
P{UASp-Socs36E.ΔSB}
Key Links
Transgenic product class
inframe_deletion
(Callus and Mathey-Prevot, 2002)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Callus and Mathey-Prevot, 2002)
Mutagen
in vitro construct
(Silver et al., 2005, Callus and Mathey-Prevot, 2002)
Progenitor genotype
Socs36EUASp.cCa
(Callus and Mathey-Prevot, 2002)
Carried in construct
P{UASp-Socs36E.ΔSB}
Cytology
Description

A C-terminal 60 amino acid residue deletion that removes the SOCS box.

(Callus and Mathey-Prevot, 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
Socs36E
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Socs36EΔSB.Scer\UAS.P\T, under the control of Scer\GAL4c306, weakly inhibits border cell migration. Such egg chambers have an average of 4.9 border cells.

      (Silver et al., 2005)

      Expression of the Socs36EΔSB.Scer\UAS.P\T transgene under the control of Scer\GAL4en-e16E produces loss of the anterior cross vein with a 76% penetrance compared to the 99% penetrance observed when the Socs36E wild-type transgene is expressed. Scer\GAL4en-e16E>Socs36EΔSB.Scer\UAS.P\T expression also causes humeral outgrowth, but at a greatly reduced penetrance (17%) compared to that of the wild-type transgene (38%). The penetrance of the missing haltere phenotype is also reduced in flies expressing Socs36EΔSB.Scer\UAS.P\T.

      (Callus and Mathey-Prevot, 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Socs36EΔSB.Scer\UAS.P\T suppresses the rough eye and extra R7 photoreceptor cell phenotype caused by expression of sevS11.T:Hsap\MYC under the control of Scer\GAL4hs.2sev.

      (Almudi et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Socs36EΔSB.Scer\UAS.P\T
      Socs36EΔSB.UASp
      Name Synonyms
      Secondary FlyBase IDs
        References (3)