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General Information
Symbol
Dmel\sle057
Species
D. melanogaster
Name
FlyBase ID
FBal0191002
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the P{GS} element, resulting in deletion of sle from -150bp to 1535bp relative to the transcription start site, which removes a short upstream regulatory region and a portion of the open reading frame.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Adult sle057 mushroom bodies are smaller than in wild-type, with fewer neurons (of all classes). γ and α/β lobes are thinner in these mutants, while the number of α'/β' neurons is reduced dramatically, as is the number of pioneer α/β neurons. In addition, the α/β axonal bundles are already clearly visible at 24 hour after pupal formation, indicating that the pioneer α'/β' to α/β transition is not significantly delayed.

sle057 flies emerge from the pupal case one day later than wild type. The mushroom body of sle057 mutants is abnormal; the α and β lobes are thinner than in wild type and the β lobes are fused. The sle057 pupal mushroom body has half the number of neurons found in wild type and neuroblasts are significantly smaller. The initial proliferation of mushroom body neuroblasts at one day after egg laying (AEL) is the same as wild type, but sle057 neuroblast proliferation starts to decrease at 5 days AEL, a stage at which proliferation is rapid in wild type, and ceases prematurely by 9 days AEL. The relative lengths of interphase and metaphase in the mutant neuroblasts is not significantly different from wild type. Nucleolar morphology is altered in sle057 mutants. While wild-type nucleoli are variable in shape and have a roughly organized surface, sle057 nucleoli are spherical with a smooth surface and tightly organized components. This nucleolar phenotype is general as it has been observed in neuroblasts, nurse cells and imaginal wing discs. The cell cycle profile of cells in the third instar larval wing disc is not significantly different in sle057 mutants to wild type. sle057 nurse cells are abnormal and irregular in shape.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)