FB2025_01 , released February 20, 2025
Allele: Dmel\GmdH78
Open Close
General Information
Symbol
Dmel\GmdH78
Species
D. melanogaster
Name
FlyBase ID
FBal0191005
Feature type
allele
Associated gene
Dmel\Gmd
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Sasamura et al., 2007)
Mutagen
P-element activity
(Sasamura et al., 2007)
Progenitor genotype
P{GSV6}GmdGS13045
(Sasaki et al., 2007)
Cytology
Description

Imprecise excision of the P{GSV6} element, resulting in deletion of most Gmd exons 3' of the original insertion site.

(Sasaki et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      GmdH78 homozygous m/z embryos exhibit a very low penetrance neurogenic phenotype (2/19) at 25[o]C. At 30[o]C these embryos display a fully penetrant neurogenic phenotype.

      (Ishio et al., 2015)

      Homozygous clones in the adult intestine contain more cells per clone than wild-type controls. The fraction of homozygous clones containing dividing cells is increased compared to wild type and mutant clones containing more than one dividing cell are seen. Marker analysis suggests that the number of intestinal stem cells is increased. Terminal differentiation of enteroendocrine cells and enterocytes is unaffected in the mutant clones.

      (Perdigoto et al., 2011)

      GmdH78 homozygotes barely survive to the third-instar larval stage.

      (Sasaki et al., 2007)

      GmdH78 heterozygotes exhibit a wild-type wing phenotype.

      (Ishikawa et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Ncdc10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4tub.PU suppresses the formation of supernumerary intestinal stem cell-like cells which are produced in homozygous GmdH78 clones in the adult intestine.

      (Perdigoto et al., 2011)

      The wings of GmdH78/+ Gfr1/Gfr1 flies exhibit a significantly more severe wing phenotype than Gfr1 homozygotes.

      (Ishikawa et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      References (8)