Allele Dmel\dj-1β^b

General Information
Symbol	Dmel\dj-1β^b	Species	D. melanogaster
Name		FlyBase ID	FBal0191235
Feature type	allele	Associated gene	Dmel\dj-1β

Allele class	amorphic allele - genetic evidence
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	amorphic allele - genetic evidence (Menzies et al., 2005)
Mutagen	P-element activity (Menzies, 2005)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{EP}cindr^EP3700 (Menzies, 2005)
Nature of the lesion	Statement Reference Local hopping of the P{EP} resulting in its insertion at base pair 739 of the dj-1β gene. (Menzies, 2005)
Caused by insertion	P{EP}dj-1β^b (Menzies, 2005)
Cytology
Phenotypic Data
Phenotypic Class
	chemical resistant (Menzies et al., 2005) chemical sensitive (Menzies et al., 2005)
Phenotype Manifest In
	dopaminergic neuron (Menzies et al., 2005)
Detailed Description
	Statement Reference dj-1β^b flies have the same amount of dopaminergic neurons as controls at 20 or 40 days old. However, at 60 days, the mutants show a higher number of dopaminergic neurons compared to controls. Dopaminergic cell clusters in PPL1, PPM1/2 and PPL2 regions of the brain survive better in dj-1β^b mutants compared to other regions. However, despite the reduction in dopaminergic neuron loss, 60 day-old dj-1β^b flies display sedentary behaviour similar to wild-type flies of the same age. dj-1β^b flies, like wild-type flies, show no reduction in the amount of serotoninergic neurons between the ages of 10 and 60 days. dj-1β^b flies show resistance to paraquat. However, these flies are more sensitive to H₂O₂ than wild-type flies. (Menzies et al., 2005)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	dj-1β^b
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Menzies et al., 2005, Curr. Biol. 15(17): 1578--1582 Roles of Drosophila DJ-1 in Survival of Dopaminergic Neurons and Oxidative Stress. [FBrf0187320]
Supplementary material	Menzies, 2005, Curr. Biol. 15(17): [title not yet available] [FBrf0191743]

Allele Dmel\dj-1βb

Allele Dmel\dj-1β^b