Allele Dmel\pix^3c2

General Information
Symbol	Dmel\pix^3c2	Species	D. melanogaster
Name		FlyBase ID	FBal0191248
Feature type	allele	Associated gene	Dmel\pix

Map ( GBrowse )
Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Coelho et al., 2005)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3L:8,966,693..8,966,693 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=A8966693T pr_change=Q231L\|pix-PB,Q231L\|pix-PA reported_pr_change=Q231L (Coelho et al., 2005)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Missense mutation. (Coelho et al., 2005) Amino acid replacement: Q231L. (Coelho et al., 2005)
Cytology
Phenotypic Data
Phenotypic Class
	developmental rate defective \| dominant (Coelho et al., 2005, Coelho et al., 2005) lethal (with pix^3c3) (Coelho et al., 2005) lethal \| embryonic stage \| recessive (Coelho et al., 2005) lethal \| recessive (Coelho et al., 2005) Minute \| dominant (Coelho et al., 2005) small body \| dominant (Coelho et al., 2005, Coelho et al., 2005)
Phenotype Manifest In
	chaeta (Coelho et al., 2005) interommatidial bristle (Coelho et al., 2005) macrochaeta (Coelho et al., 2005) ommatidium (Coelho et al., 2005) wing (Coelho et al., 2005, Coelho et al., 2005)
Detailed Description
	Statement Reference Heterozygotes have a Minute bristle and developmental delay phenotype. Heterozygotes are reduced in body and wing size when reared under uncrowded, carefully synchronised culture conditions. (Coelho et al., 2005) pix^3c2/+ flies have a slow developmental time (10-12 days) compared to wild-type flies (10 days). Adult flies are smaller than wild type with a decreased wing area, slender, short thoracic macrochaetae and occasional eye roughening. (Coelho et al., 2005)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference pix^3c2/pix[+] is an enhancer of visible phenotype of Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}, Scer\GAL4^Bx-MS1096 (Coelho et al., 2005) pix^3c2/pix[+] is an enhancer of visible phenotype of Scer\GAL4^Bx-MS1096, aos^Scer\UAS.cMa (Coelho et al., 2005)
Other
Statement Reference E-3c1¹, pix^3c2/pix[+] has wild-type phenotype (Coelho et al., 2005) E-3c1¹, pix^3c2 has wild-type phenotype (Coelho et al., 2005) E-3c4[+]/E-3c4⁴, pix^3c2 has wild-type phenotype (Coelho et al., 2005) E-3c4⁴, pix^3c2 has wild-type phenotype (Coelho et al., 2005) E-3c7⁷, pix^3c2/pix[+] has small body phenotype (Coelho et al., 2005) E-3c7⁷/E-3c7[+], pix^3c2 has small body \| dominant phenotype (Coelho et al., 2005) lep^3c5, pix^3c2/pix[+] has lethal phenotype (Coelho et al., 2005) lep^3c5/lep[+], pix^3c2 has lethal \| dominant phenotype (Coelho et al., 2005) lep^3c6, pix^3c2 has wild-type phenotype (Coelho et al., 2005) lep^3c6/lep[+], pix^3c2 has wild-type phenotype (Coelho et al., 2005)
Phenotype Manifest In
Enhancer of
Statement Reference pix^3c2/pix[+] is an enhancer of wing phenotype of Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}, Scer\GAL4^Bx-MS1096 (Coelho et al., 2005, Coelho et al., 2005) pix^3c2/pix[+] is an enhancer of wing phenotype of Scer\GAL4^Bx-MS1096, aos^Scer\UAS.cMa (Coelho et al., 2005)
NOT Enhancer of
Statement Reference pix^3c2/pix[+] is a non-enhancer of wing vein phenotype of Scer\GAL4^Bx-MS1096, aos^Scer\UAS.cMa (Coelho et al., 2005)
Additional Comments
Genetic Interactions
Statement Reference pix^3c2 dominantly enhances the small wing phenotype caused by expression of argos^Scer\UAS.cMa under the control of Scer\GAL4^Bx-MS1096, but does not enhance the argos^Scer\UAS.cMa ; Scer\GAL4^Bx-MS1096 wing vein loss phenotype. (Coelho et al., 2005) The small wing phenotype of Scer\GAL4^Bx-MS1096>Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} flies is enhanced by pix^3c2/+. (Coelho et al., 2005)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer
	Selected as: a dominant modifier of the small wing phenotype caused by expression of Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^Bx-MS1096. (Coelho et al., 2005)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	E-3c² (Coelho et al., 2005) pix^3c2
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Coelho et al., 2005, Genetics 171(2): 597--614 A genetic screen for dominant modifiers of a small-wing phenotype in Drosophila melanogaster identifies proteins involved in splicing and translation. [FBrf0190712] Coelho et al., 2005, Development 132(24): 5411--5424 Growth and cell survival are unevenly impaired in pixie mutant wing discs. [FBrf0190282]

Allele Dmel\pix3c2

Allele Dmel\pix^3c2