FB2025_01 , released February 20, 2025
Allele: Dmel\CheB42aΔ5-22
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General Information
Symbol
Dmel\CheB42aΔ5-22
Species
D. melanogaster
Name
FlyBase ID
FBal0191308
Feature type
allele
Associated gene
Dmel\CheB42a
Associated Insertion(s)
P{?SUPor-P}CheB42aΔ5-22
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Lin et al., 2005)
Progenitor genotype
P{SUPor-P}mimKG05881
(Lin et al., 2005)
Associated Insertion(s)
P{?SUPor-P}CheB42aΔ5-22
Caused by aberration
Df(2R)Δ5-22
Cytology
Description

Imprecise excision of P{SUPor-P}KG05881 generates a genomic deletion removing the 5' section and upstream promoter regions of CheB42a, along with some enhancer regions of ppk25. Partial P-element sequences remain.

(Lin et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Males homozygous for CheB42aΔ5-22 have a much reduced courtship index relative to controls. However, these flies walk and preen more than controls or flies carrying CheB42a+tTg1. The typical climbing response to mechanosensory detection of gravity, stimulation of food intake by gustatory detection of sucrose is not affected in CheB42aΔ5-22 homozygous males.

      (Lin et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      CheB42aΔ5-22, CheB42a+tTg1 has abnormal behavior phenotype, non-suppressible by ppk25+tTg1

      (Lin et al., 2005)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The addition of ppk25+tTg1 (with CheB42a+tTg1) has no effect on the walking and preening habits of CheB42aΔ5-22 homozygous males.

      (Lin et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      CheB42aΔ5-22
      Name Synonyms
      Secondary FlyBase IDs
        References (2)