FB2025_02 , released April 17, 2025
Allele: Dmel\hpoKS240
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General Information
Symbol
Dmel\hpoKS240
Species
D. melanogaster
Name
FlyBase ID
FBal0191417
Feature type
allele
Associated gene
Dmel\hpo
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Udan et al., 2003)
Mutagen
FLPase
(Udan et al., 2003)
ethyl methanesulfonate
(Udan et al., 2003)
Progenitor genotype
Cytology
Description

Scer\FLP1ey.PB-mediated EMS generates somatic clones of hpo mutants.

(Udan et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:19,495,138..19,495,138 [-]
Nucleotide change:

G19495138A

Amino acid change:

W518term | hpo-PA; W518term | hpo-PB

Reported amino acid change:

W518term

Comment:

TGG to TGA

(Udan et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  autism spectrum disorder
      modeled by Abca3GD3708
      (Ueoka et al., 2020)
      ameliorates  neurodegenerative disease
      modeled by FIG4KK102943
      (Kushimura et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      hpoKS240/+ adults are hypoactive when compared to controls.

      (Ueoka et al., 2020)

      hpoKS240 mutants exhibit 'overgrowth' phenotypes. The adult head is enlarged, with larger eyes and an expanded, fold cuticle found on the head and antennae.

      (Udan et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      hpoKS240 is a non-enhancer of increased rate of movement | adult stage phenotype of Abca3GD3708, Scer\GAL4elav.PLu

      (Ueoka et al., 2020)
      Suppressor of
      Statement
      Reference

      hpoKS240/hpo[+] is a suppressor | partially of decreased size | adult stage phenotype of PatroninGD11946, Scer\GAL4en.PU

      (Yang and Choi, 2021)

      hpoKS240/hpo[+] is a suppressor | partially of visible | adult stage phenotype of PatroninGD11946, Scer\GAL4en.PU

      (Yang and Choi, 2021)
      NOT Suppressor of
      Statement
      Reference

      hpoKS240 is a non-suppressor of increased rate of movement | adult stage phenotype of Abca3GD3708, Scer\GAL4elav.PLu

      (Ueoka et al., 2020)
      Phenotype Manifest In
      NOT Enhancer of
      Suppressor of
      Statement
      Reference

      hpoKS240/hpo[+] is a suppressor | partially of wing phenotype of PatroninGD11946, Scer\GAL4en.PU

      (Yang and Choi, 2021)
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      References (8)